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公开(公告)号：US20210106607A1
公开(公告)日：2021-04-15
申请号：US17065242
申请日：2020-10-07
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： MASATO YOSHIKAWA , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC: A61K31/7084 , A61P35/00 , C07H21/00 , C07H21/02 , A61K47/68 , A61K31/7076
Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US12171777B2
公开(公告)日：2024-12-24
申请号：US18310467
申请日：2023-05-01
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC: A61K31/7084 , A61K31/7076 , A61K47/68 , A61P35/00 , C07H21/00 , C07H21/02
Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US11666594B2
公开(公告)日：2023-06-06
申请号：US17065242
申请日：2020-10-07
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC: A61K31/7084 , A61P35/00 , C07H21/00 , C07H21/02 , A61K47/68 , A61K31/7076
CPC classification number: A61K31/7084 , A61K31/7076 , A61K47/6807 , A61P35/00 , C07H21/00 , C07H21/02
Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I):
wherein each symbol is as defined in the description, or a salt thereof.-
Patent Agency Ranking
公开(公告)号：US09890145B2
公开(公告)日：2018-02-13
申请号：US15137161
申请日：2016-04-25
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Masato Yoshida , Kazuaki Takami , Yusuke Tominari , Zenyu Shiokawa , Akito Shibuya , Yusuke Sasaki , Tony Gibson , Terufumi Takagi
IPC: C07D401/14 , C07D487/04 , C07D417/14 , C07D487/10 , A61P37/00 , C07D403/14 , A61K31/4155 , C07D413/14 , C07D401/04 , C07D409/14 , C07D405/14 , A61K9/06 , A61K9/20 , A61K9/48 , C07D403/04 , C07D471/04 , C07D471/10 , C07D491/107 , C07D495/04
CPC classification number: C07D413/14 , A61K9/06 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04
Abstract: The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory disease, autoimmune disease, osteoarticular degenerative disease, neoplastic disease and the like, and a medicament containing thereof. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US20210137962A9
公开(公告)日：2021-05-13
申请号：US16185258
申请日：2018-11-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Yoshitomi , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Yoshihisa Nakada , Michiyo Mochizuki
IPC: A61K31/7084 , A61P35/00 , A61K47/68 , A61K31/7076
Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US09321757B2
公开(公告)日：2016-04-26
申请号：US14533326
申请日：2014-11-05
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Masato Yoshida , Kazuaki Takami , Yusuke Tominari , Zenyu Shiokawa , Akito Shibuya , Yusuke Sasaki , Tony Gibson , Terufumi Takagi
IPC: C07D401/14 , C07D487/04 , C07D417/14 , C07D487/10 , A61P37/00 , C07D403/14 , A61K31/4155 , C07D413/14 , C07D409/14 , C07D405/14 , C07D401/04 , A61K9/06 , A61K9/20 , A61K9/48
CPC classification number: C07D413/14 , A61K9/06 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04
Abstract: The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory disease, autoimmune disease, osteoarticular degenerative disease, neoplastic disease and the like, and a medicament containing thereof. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供具有IRAK-4抑制作用的杂环化合物，其可用于预防或治疗炎性疾病，自身免疫性疾病，骨关节炎性退行性疾病，肿瘤性疾病等，以及含有它们的药物。 本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US10980825B2
公开(公告)日：2021-04-20
申请号：US16185258
申请日：2018-11-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Yoshihisa Nakada , Michiyo Mochizuki
IPC: A61K31/7084 , A61K31/7076 , A61K47/68 , A61P35/00 , C07H21/00 , C07H21/02
Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20190192549A1
公开(公告)日：2019-06-27
申请号：US16185258
申请日：2018-11-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： MASATO YOSHIKAWA , Morihisa Saitoh , Taisuke Kato , Yayoi Yoshitomi , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC: A61K31/7084 , A61P35/00 , A61K47/68 , A61K31/7076
CPC classification number: A61K31/7084 , A61K31/7076 , A61K47/6807 , A61P35/00 , C07H21/00 , C07H21/02
Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
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