公开(公告)号：US20220340613A1

公开(公告)日：2022-10-27

申请号：US17697247

申请日：2022-03-17

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of The University of Texas System

Inventor： Boyu ZHONG ,  Heping SHI ,  Yuanwei DAI ,  Qi WEI ,  Chuo CHEN ,  Zhijian CHEN ,  Lijun SUN

IPC: C07H21/02 ,  A61K45/06 ,  C07H21/00 ,  A61K31/7084 ,  C07H21/04

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

公开(公告)号：US20180230177A1

公开(公告)日：2018-08-16

申请号：US15953492

申请日：2018-04-15

Applicant: IMMUNE SENSOR, LLC ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Qi WEI ,  Yuanwei DAI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07H21/02 ,  A61K31/7084 ,  A61K45/06 ,  C07H21/04

CPC classification number: C07H21/02 ,  A61K31/7084 ,  A61K45/06 ,  C07H21/00 ,  C07H21/04

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

公开(公告)号：US20210015941A1

公开(公告)日：2021-01-21

申请号：US16933845

申请日：2020-07-20

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Heping SHI ,  Qi WEI ,  Chuo CHEN ,  Lijun SUN ,  Jian QIU ,  Youtong WU

IPC: A61K47/68 ,  A61P35/00

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

公开(公告)号：US20240043393A1

公开(公告)日：2024-02-08

申请号：US18158046

申请日：2023-01-23

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing LI ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/14 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D277/34 ,  C07D513/04 ,  A61K31/429 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/519 ,  A61K31/427 ,  C07D277/40 ,  A61K31/437 ,  A61K31/426 ,  A61K31/381 ,  A61K31/433 ,  A61K31/4709 ,  A61K39/39 ,  A61K45/06 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  C07D277/36 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D417/14

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20230357158A1

公开(公告)日：2023-11-09

申请号：US18353718

申请日：2023-07-17

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Qi WEI ,  Heping SHI ,  Matt TSCHANTZ ,  Jian QIU ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D215/12 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14

CPC classification number: C07D215/12 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20180230115A1

公开(公告)日：2018-08-16

申请号：US15953494

申请日：2018-04-15

Applicant: IMMUNE SENSOR, LLC ,  The Board of Regents of the University of Texas System

Inventor： Boyu ZHONG ,  Lijun SUN ,  Heping SHI ,  Jing Li ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D277/34 ,  C07D417/06 ,  A61K31/4439 ,  C07D417/04 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/506 ,  C07D403/06 ,  A61K31/501 ,  C07D513/04 ,  A61K31/429 ,  C07D277/36 ,  C07D417/12 ,  C07D495/04 ,  A61K31/4365 ,  C07D417/10 ,  A61K31/4985 ,  A61K31/519 ,  C07D417/14 ,  C07D471/04 ,  A61K31/454

CPC classification number: C07D277/34 ,  A61K31/381 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K39/39 ,  A61K45/06 ,  C07D277/36 ,  C07D277/40 ,  C07D403/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  A61K2300/00

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20160115177A1

公开(公告)日：2016-04-28

申请号：US14890905

申请日：2014-05-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Lawrence LUM ,  Chuo CHEN

IPC: C07D495/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/519

CPC classification number: C07D495/04 ,  A61K31/519 ,  A61K45/06 ,  A61N5/10 ,  A61K2300/00

Abstract: The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.

Abstract translation: 本发明一般涉及蛋白信号传导。 特别地，公开了抑制Wnt蛋白信号通路的化合物。 这些化合物可用于治疗Wnt蛋白信号传导相关疾病和病症如癌症，退行性疾病，II型糖尿病和骨细胞减少症。

公开(公告)号：US20240002346A1

公开(公告)日：2024-01-04

申请号：US18177732

申请日：2023-03-02

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Qi WEI ,  Heping SHI ,  Matt TSCHANTZ ,  Jian QIU ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14

CPC classification number: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D409/14 ,  C07D405/14

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20230081291A1

公开(公告)日：2023-03-16

申请号：US17446951

申请日：2021-09-03

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Jian QIU ,  Qi WEI ,  Matt TSCHANTZ ,  Heping SHI ,  Youtong WU ,  Huiling TAN ,  Lijun SUN ,  Chuo CHEN ,  Zhijian CHEN

IPC: C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D403/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/08 ,  C07D405/14 ,  C07F9/6506 ,  C07F9/6503 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D491/048

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20220105198A1

公开(公告)日：2022-04-07

申请号：US17553624

申请日：2021-12-16

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Zhijian CHEN ,  Heping SHI ,  Qi WEI ,  Chuo CHEN ,  Lijun SUN ,  Jian QIU ,  Youtong WU

IPC: A61K47/68 ,  A61P35/00

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.