公开(公告)号：US20200215100A1

公开(公告)日：2020-07-09

申请号：US16702164

申请日：2019-12-03

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Shao-Ling HUANG ,  David MCPHERSON ,  Yong-Jian GENG ,  Xing YIN ,  Hyunggun KIM ,  Melvin KLEGERMAN ,  Tao PENG

IPC分类号： A61K33/00 ,  A61K47/02 ,  A61K47/14 ,  A61K9/00 ,  A61K47/24 ,  A61K9/107 ,  A61K47/44 ,  A23D7/005 ,  A23L33/115 ,  A23L33/16 ,  A23L33/25 ,  A61K47/69 ,  A61J1/14 ,  A61K47/28 ,  A61K47/42

摘要： Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided.

公开(公告)号：US20160030470A1

公开(公告)日：2016-02-04

申请号：US14775907

申请日：2014-03-17

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Shao-Ling HUANG ,  David MCPHERSON ,  Yong-Jian GENG ,  Xing YIN ,  Hyunggun KIM ,  Melvin KLEGERMAN ,  Tao PENG

IPC分类号： A61K33/00 ,  A61K47/44 ,  A61K47/28 ,  A61K47/24 ,  A61J1/14 ,  A61K9/107 ,  A61K9/00 ,  A23L1/304 ,  A23L1/30 ,  A23L1/308 ,  A61K47/48 ,  A61K47/42

CPC分类号： A61K33/00 ,  A23D7/0053 ,  A23L33/115 ,  A23L33/16 ,  A23L33/25 ,  A23V2002/00 ,  A61J1/1468 ,  A61K9/0095 ,  A61K9/107 ,  A61K47/02 ,  A61K47/14 ,  A61K47/24 ,  A61K47/28 ,  A61K47/42 ,  A61K47/44 ,  A61K47/6951 ,  A61K2300/00 ,  A23V2250/00 ,  A23V2250/10 ,  A23V2250/18

摘要： Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided. The present invention relates generally to the fields of molecular biology, medicine and nutraceuticals. More particularly, it concerns methods for oral delivery of inert gas compositions, such as Xenon or Argon, for the treatment and prevention of disease.

摘要翻译： 本文提供了用于口服给药和递送贵重气体（例如氙气或氩气）的新型组合物。 还提供了用这种组合物治疗和预防神经元或心血管损伤的方法。 本发明一般涉及分子生物学，药物和营养品领域。 更具体地，涉及用于口服递送诸如氙或氩的惰性气体组合物用于治疗和预防疾病的方法。

公开(公告)号：US20180271897A1

公开(公告)日：2018-09-27

申请号：US15695735

申请日：2017-09-05

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Shao-Ling HUANG ,  David MCPHERSON ,  Yong-Jian GENG ,  Xing YIN ,  Hyunggun KIM ,  Melvin KLEGERMAN ,  Tao PENG

IPC分类号： A61K33/00 ,  A23L33/115 ,  A23D7/005 ,  A61K47/02 ,  A23L33/25 ,  A61K47/28 ,  A23L33/16 ,  A61K9/107 ,  A61K47/69 ,  A61K47/42 ,  A61K47/24 ,  A61K47/14 ,  A61K9/00 ,  A61J1/14 ,  A61K47/44

CPC分类号： A61K33/00 ,  A23D7/0053 ,  A23L33/115 ,  A23L33/16 ,  A23L33/25 ,  A23V2002/00 ,  A61J1/1468 ,  A61K9/0095 ,  A61K9/107 ,  A61K47/02 ,  A61K47/14 ,  A61K47/24 ,  A61K47/28 ,  A61K47/42 ,  A61K47/44 ,  A61K47/6951 ,  A61K2300/00 ,  A23V2250/00 ,  A23V2250/10 ,  A23V2250/18

摘要： Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided.

公开(公告)号：US20210378959A1

公开(公告)日：2021-12-09

申请号：US17229627

申请日：2021-04-13

申请人： The Board of Regents of The University of Texas System

发明人： Shao-Ling HUANG ,  Melvin E. KLEGERMAN ,  Yong-Jian GENG ,  Hyunggun KIM ,  David D. MCPHERSON

IPC分类号： A61K9/127 ,  A61K33/00 ,  A61K9/00 ,  A61K41/00

摘要： Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.