公开(公告)号：US20230112075A1

公开(公告)日：2023-04-13

申请号：US17911387

申请日：2021-03-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Alexander Marson ,  Brian Shy ,  Justin Eyquem ,  Vivasvan Vykunta

IPC: C12N15/113 ,  C07K14/725 ,  C12N9/22

Abstract: The disclosure provides compositions and methods for for modifying an endogenous cell surface protein (e.g., an endogenous TCR) in a cell (e.g., a T cell) with a CAR or an exogenous protein (e.g., an exogenous intracellular or cell surface protein (e.g., an exogenous TCR)).

公开(公告)号：US20240366788A1

公开(公告)日：2024-11-07

申请号：US18290799

申请日：2022-07-22

Applicant: Duke University ,  The Regents of the University of California

Inventor： Aravind Asokan ,  Jonathan Ian Ark ,  Lawrence Patrick Havlik ,  Justin Eyquem ,  William Nyberg

IPC: A61K48/00 ,  A61K35/17 ,  A61P37/04 ,  C07K14/005 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: Disclosed herein are adeno-associated virus (AAV) vectors comprising capsid protein variants. Also disclosed herein are pharmaceutical compositions comprising these AAV vectors and capsid protein variants as well as methods of making such vectors and capsid protein variants. Disclosed herein are methods of using the disclosed AAV vectors and disclosed capsid protein variants.