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6 条记录 (耗时 0.023 秒)

    METHOD OF MEASURING NEPRILYSIN ACTIVITY
    1.
    发明申请
    METHOD OF MEASURING NEPRILYSIN ACTIVITY 审中-公开
    测量NEPRILYSIN活性的方法

    公开(公告)号：US20090298775A1

    公开(公告)日：2009-12-03

    申请号：US12491120

    申请日：2009-06-24

    申请人： Takaomi Saido ,  Nobuhisa Iwata ,  Satoshi Tsubuki ,  Yoshie Takaki ,  Takashi Saito ,  Tadashi Nakaya

    发明人： Takaomi Saido ,  Nobuhisa Iwata ,  Satoshi Tsubuki ,  Yoshie Takaki ,  Takashi Saito ,  Tadashi Nakaya

    IPC分类号： A61K38/31 ,  A61K38/10 ,  A61K38/12

    CPC分类号： C12Q1/37 ,  G01N33/6896 ,  G01N2333/96486 ,  G01N2500/00

    摘要： The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin in nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. Thus, the compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring the activity of neprilysin in accordance with the present invention, is useful as a preventive and/or therapeutic agent for Alzheimer's disease. The method of measuring the activity of the present invention can be used for presymptomatic diagnosis of Alzheimer's disease.

    摘要翻译： 本发明提供了测定尿丙氨酸等的活性的方法。更具体地，本发明提供了测定神经细胞中尿丙氨酸蛋白酶活性的方法。 通过测量尿丙氨酸的活性来筛选蛋白质，肽或增强神经细胞中neprilysin的活性或表达的化合物的方法; 增强头孢氨苄的活性或表达的方法; 等等。 因此，通过使用根据本发明的测定尿丙氨酸的活性的方法的筛选方法获得的增强头孢氨苄的活性和/或表达的化合物可用作预防和/或治疗剂 阿尔茨海默氏病。 测定本发明活性的方法可用于阿尔茨海默病的症状诊断。

    Method of measuring neprilysin activity
    2.
    发明申请
    Method of measuring neprilysin activity 失效

    公开(公告)号：US20060008842A1

    公开(公告)日：2006-01-12

    申请号：US10512588

    申请日：2003-04-24

    申请人： Takaomi Saido ,  Nobuhisa Iwata ,  Satoshi Tsubuki ,  Yoshie Takaki ,  Takashi Saito

    发明人： Takaomi Saido ,  Nobuhisa Iwata ,  Satoshi Tsubuki ,  Yoshie Takaki ,  Takashi Saito

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/37 ,  G01N33/6896 ,  G01N2333/96486 ,  G01N2500/00

    摘要： The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. Thus, the compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring the activity of neprilysin in accordance with the present invention, is useful as a preventive and/or therapeutic agent for Alzheimer's disease. The method of measuring the activity of the present invention can be used for presymptoms diagnosis of Alzheimer's disease.

    Method of measuring neprilysin activity
    3.
    发明授权
    Method of measuring neprilysin activity 失效
    测定尿蛋白活性的方法

    公开(公告)号：US07572574B2

    公开(公告)日：2009-08-11

    申请号：US10512588

    申请日：2003-04-24

    申请人： Takaomi Saido ,  Nobuhisa Iwata ,  Satoshi Tsubuki ,  Yoshie Takaki ,  Takashi Saito ,  Tadashi Nakaya

    发明人： Takaomi Saido ,  Nobuhisa Iwata ,  Satoshi Tsubuki ,  Yoshie Takaki ,  Takashi Saito ,  Tadashi Nakaya

    IPC分类号： C12Q1/00 ,  G01N33/53 ,  G01N33/567 ,  G01N33/542 ,  G01N33/537

    CPC分类号： C12Q1/37 ,  G01N33/6896 ,  G01N2333/96486 ,  G01N2500/00

    摘要： The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. Thus, the compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring the activity of neprilysin in accordance with the present invention, is useful as a preventive and/or therapeutic agent for Alzheimer's disease. The method of measuring the activity of the present invention can be used for presymptoms diagnosis of Alzheimer's disease.

    摘要翻译： 本发明提供了测定尿丙氨酸等的活性的方法。更具体地，本发明提供了测定神经细胞中尿丙氨酸蛋白酶活性的方法。 通过测定尿丙氨酸的活性来筛选蛋白质，肽或增强neprilysin神经细胞活性或表达的化合物的方法; 增强头孢氨苄的活性或表达的方法; 等等。 因此，通过使用根据本发明的测定尿丙氨酸的活性的方法的筛选方法获得的增强头孢氨苄的活性和/或表达的化合物可用作预防和/或治疗剂 阿尔茨海默氏病。 测定本发明的活性的方法可用于阿尔茨海默病的症状诊断。

    Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof
    4.
    发明授权
    Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof 有权
    表达FAD APP 716的阿尔茨海默病模型小鼠及其用途

    公开(公告)号：US07745688B2

    公开(公告)日：2010-06-29

    申请号：US11765730

    申请日：2007-06-20

    申请人： Takaomi Saido ,  Nobuhisa Iwata ,  Takashi Saito ,  Takahiro Suemoto ,  Jiro Takano

    发明人： Takaomi Saido ,  Nobuhisa Iwata ,  Takashi Saito ,  Takahiro Suemoto ,  Jiro Takano

    IPC分类号： A01K67/033 ,  G01N33/00

    CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2227/106 ,  A01K2267/0312

    摘要： The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid β peptide (Aβ) or a living part thereof, characterized in that Aβ42/Aβ40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof.

    摘要翻译： 本发明提供了含有能够产生人淀粉样蛋白的嵌合淀粉样蛋白前体蛋白（APP）基因的非人模型的阿尔茨海默病（AD）哺乳动物。 肽（A＆bgr）或其活性部分，其特征在于8周龄的A / B比值与约7倍或更多（纯合子中约140倍或更多）相比较， 相应的野生型哺乳动物。 此外，本发明提供了哺乳动物或其生物体部分，其特征还在于，与相应的野生型哺乳动物相比，APP表达水平没有显着差异，以及用于AD的预防和/或治疗药物的筛选方法 生物流体中的生物标志物和淀粉样蛋白沉积的分子成像或脑中的其它病理变化，以便使用哺乳动物或其生物部分进行AD的早期诊断。