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41 条记录 (耗时 0.024 秒)

    Sulfonamide derivative having isoxazole ring
    2.
    发明授权
    Sulfonamide derivative having isoxazole ring 失效
    具有异恶唑环的磺酰胺衍生物

    公开(公告)号：US07825146B2

    公开(公告)日：2010-11-02

    申请号：US10565948

    申请日：2004-07-28

    申请人： Fumihiko Watanabe ,  Naoki Yoshikawa ,  Yoshinori Tamura

    发明人： Fumihiko Watanabe ,  Naoki Yoshikawa ,  Yoshinori Tamura

    IPC分类号： A61K31/422

    CPC分类号： C07D261/08 ,  A61K31/42

    摘要： A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: R6 is optionally substituted aryl and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof; and a metalloproteinase inhibitor containing them.

    摘要翻译： 由通式（I-A）表示的化合物：其中R1是羟基等; R2是任选取代的低级烷基等; R3是氢原子等; R4是任选取代的亚芳基等; R5是由下式表示的基团：R6是任选取代的芳基等，其光学活性物质，其药学上可接受的盐或其溶剂化物; 和含有它们的金属蛋白酶抑制剂。

    MMP-13 SELECTIVE INHIBITOR
    3.
    发明申请
    MMP-13 SELECTIVE INHIBITOR 审中-公开
    MMP-13选择性抑制剂

    公开(公告)号：US20090069304A1

    公开(公告)日：2009-03-12

    申请号：US12281216

    申请日：2007-03-01

    申请人： Mikayo Hayashi ,  Fumihiko Watanabe

    发明人： Mikayo Hayashi ,  Fumihiko Watanabe

    IPC分类号： A61K31/5513 ,  C07D243/08 ,  C07D241/04 ,  A61K31/4965

    CPC分类号： C07D209/86 ,  C07D211/96 ,  C07D241/04 ,  C07D243/08 ,  C07D295/22

    摘要： Since it is thought that if the activity of MMP-13 can be inhibited, this will largely contribute to improvement or prevention of progession of pathological states, particularly, osteoarthritis (OA), resulting from or associated with the MMP-13 activity, the development of MMP-13 inhibitors is anticipated. There are provided a compound represented by the general formula (I): wherein R1 is optionally substituted aryl etc.; Z is C1-C5 alkylene which may be substituted and may be interrupted with a substituent selected from Substituent group a etc.; A is the formula: (R6 and R7 are each independently halogen, lower alkyl etc.; m and n are each independently 0, 1, or 2); R2 is a hydrogen atom, optionally substituted lower alkyl etc.; R3 is a hydrogen atom, optionally substituted lower alkyl etc.; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxy, lower alkyloxy etc.), or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof, and a pharmaceutical composition containing it as an active ingredient, which has the MMP-13 inhibiting activity.

    摘要翻译： 由于认为如果可以抑制MMP-13的活性，这将大大有助于改善或预防由MMP-13活性引起或与MMP-13活性相关的病理状态，特别是骨关节炎（OA），发展 的MMP-13抑制剂。 提供由通式（I）表示的化合物：其中R 1是任选取代的芳基等; Z是可以被取代的C1-C5亚烷基，可以被选自取代基组a等的取代基中断; A是下式：（R 6和R 7各自独立地为卤素，低级烷基等; m和n各自独立地为0,1或2）; R2是氢原子，任选取代的低级烷基等; R3是氢原子，任选取代的低级烷基等; R4是氢原子; 或者R 3和R 4可以与相邻的碳原子一起与环一起取代; R5是羟基，低级烷氧基等）或光学活性异构体，其药学上可接受的盐或溶剂合物，以及含有其作为活性成分的具有MMP-13抑制活性的药物组合物。

    Ink jet recording apparatus
    4.
    发明授权
    Ink jet recording apparatus 失效
    喷墨记录装置

    公开(公告)号：US5206666A

    公开(公告)日：1993-04-27

    申请号：US617365

    申请日：1990-11-23

    申请人： Fumihiko Watanabe ,  Takeshi Ono

    发明人： Fumihiko Watanabe ,  Takeshi Ono

    IPC分类号： B41J2/165 ,  B41J13/00 ,  B41J13/14 ,  B41J25/316

    CPC分类号： B41J2/16588 ,  B41J13/14 ,  B41J2/16585 ,  B41J25/316 ,  B41J2202/21

    摘要： An ink jet recording apparatus includes a full-line type recording head having plural ejection outlets; a shaft for rotatably supporting the recording head between a recording position in which the ink is ejected in a non-vertical direction and a non-recording position in which the ink is ejected substantially vertically; a device, disposed adjacent a recording position of the recording head, contributable to feeding of the recording material; and a positioning plate press-contacted to the contributable device to confine a recording surface of the recording material in cooperation with the contributable device.

    Process for preparing 1,4-bridged cyclohexane carboxylic acid derivatives
    5.
    发明授权
    Process for preparing 1,4-bridged cyclohexane carboxylic acid derivatives 失效
    制备1,4-桥环己烷羧酸衍生物的方法

    公开(公告)号：US5008409A

    公开(公告)日：1991-04-16

    申请号：US447513

    申请日：1989-12-07

    申请人： Masayuki Narisada ,  Mitsuaki Ohtani ,  Fumihiko Watanabe ,  Kyozo Kawata

    发明人： Masayuki Narisada ,  Mitsuaki Ohtani ,  Fumihiko Watanabe ,  Kyozo Kawata

    IPC分类号： C07C303/40 ,  C07C311/20

    CPC分类号： C07C303/40

    摘要： A process for preparing a compound of Formula (I): ##STR1## wherein R is phenyl or phenyl substituted with hydroxy, lower alkoxy, halogen or lower alkyl; Y is unsubstituted or substituted methylene, ethylene, vinylene or oxygen; m is 0 or 1; n is 0, 1 or 2; and q is 1, 2, 3 or 4; with the limitation that when m is 0, n is not 0, and when m is 1, n is not 2, which process comprises:(a) reacting an aldehyde of Formula (II); ##STR2## wherein R, Y, m and n are as defined above, under reaction conditions for the Wittig Reaction with a ylide of Formula (III):(R.sup.1).sub.3 P.dbd.CH(CH.sub.2).sub.q COOM (III) wherein R.sup.1 is C.sub.1 -C.sub.8 alkyl or aryl, M is an alkali metal and q is as defined above;(b) treating the reaction mixture of step (a) with an alkaline earth metal halide under alkaline conditions to form the alkaline earth metal salt of the carboxylic acid of Formula (I);(c) extracting the alkaline earth metal salt of the carboxylic acid of Formula (I) in an organic solvent; and(d) recovering the free carboxylic acid of Formula (I) from the organic solvent.

    Sulfonamide derivative having isoxazole ring
    7.
    发明申请
    Sulfonamide derivative having isoxazole ring 失效
    具有异恶唑环的磺酰胺衍生物

    公开(公告)号：US20060183770A1

    公开(公告)日：2006-08-17

    申请号：US10565948

    申请日：2004-07-28

    申请人： Fumihiko Watanabe ,  Naoki Yoshikawa ,  Yoshinori Tamura

    发明人： Fumihiko Watanabe ,  Naoki Yoshikawa ,  Yoshinori Tamura

    IPC分类号： A61K31/4709 ,  A61K31/454 ,  A61K31/42 ,  C07D413/02

    CPC分类号： C07D261/08 ,  A61K31/42

    摘要： A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: R6 is optionally substituted aryl and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof; and a metalloproteinase inhibitor containing them.

    摘要翻译： 由通式（I-A）表示的化合物：其中R 1是羟基等; R 2是任选取代的低级烷基等; R 3是氢原子等; R 4是任选取代的亚芳基等; R 5是由下式表示的基团：R 6是任选取代的芳基等，其光学活性物质，其药学上可接受的盐或其溶剂化物; 和含有它们的金属蛋白酶抑制剂。

    Facsimile apparatus with ink ejection recording means recoverable between the transmission of consecutive pages of image data by another facsimile apparatus
    10.
    发明授权
    Facsimile apparatus with ink ejection recording means recoverable between the transmission of consecutive pages of image data by another facsimile apparatus 失效
    具有喷墨记录装置的传真装置可在由另一传真装置传送图像数据的连续页之间恢复

    公开(公告)号：US5404229A

    公开(公告)日：1995-04-04

    申请号：US78068

    申请日：1993-06-18

    申请人： Takeshi Ono ,  Fumihiko Watanabe

    发明人： Takeshi Ono ,  Fumihiko Watanabe

    IPC分类号： B41J2/01 ,  B41J2/165 ,  B41J2/175 ,  B41J2/18 ,  B41J2/185 ,  H04N1/23 ,  H04N1/034

    CPC分类号： B41J2/1652

    摘要： An image communication apparatus includes a communication unit for communicating a procedure signal associated with communication, and image data, a recording unit for ejecting a liquid droplet onto a recording member in accordance with image data received by the communication unit, a recovery unit for performing a predetermined recovery operation of the recording unit, and a control unit for determining according to a type of procedure signal transmitted from a calling side after reception of image data of one page whether or not the recovery operation by the recovery unit is executed.

    摘要翻译： 图像通信装置包括：通信单元，用于通信与通信相关联的过程信号;以及图像数据;记录单元，用于根据由通信单元接收的图像数据将液滴喷射到记录部件上;恢复单元， 记录单元的预定恢复操作，以及控制单元，用于根据在接收到一页的图像数据之后从主叫侧发送的程序类型确定执行恢复单元的恢复操作。