公开(公告)号：US5430028A

公开(公告)日：1995-07-04

申请号：US185898

申请日：1994-01-26

申请人： Terumitsu Kaihoh ,  Sunao Takeda ,  Fujiko Konno ,  Akihiro Shibata ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tadayuki Kuraishi

发明人： Terumitsu Kaihoh ,  Sunao Takeda ,  Fujiko Konno ,  Akihiro Shibata ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tadayuki Kuraishi

IPC分类号： A61K31/47 ,  A61K31/495 ,  C07D215/56 ,  C07D401/04 ,  A61K31/55 ,  A61K31/505 ,  C07D243/00 ,  C07D243/08

CPC分类号： C07D215/56 ,  A61K31/47 ,  A61K31/495 ,  C07D401/04

摘要： A 5-aminoquinolone carboxylic acid derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means a hydrogen atom, an amino group, a linear or branched alkyl group having 1-5 carbon atoms and an alkylamino group containing a linear or branched alkyl group having 1-5 carbon atoms, R.sup.2 denotes a hydrogen atom or a linear or branched alkyl group having 1-5 carbon atoms, X stands for a halogen atom, Y means CH.sub.2, NH, CHR.sup.3 NR.sup.3, (R.sup.3 denoting a linear or branched alkyl group having 1-5 carbon atoms) or an oxygen atom, and Z stands for an oxygen atom or 2 hydrogen atoms, or a salt thereof, and an antibacterial agent containing such a derivative or salt as an active ingredient.The derivative or salt thereof exhibits strong anti-bacterial activities against Grampositive bacteria including tolerant bacteria, and is satisfactorily absorbed in a living body.

摘要翻译： PCT No.PCT / JP93 / 00694 Sec。 371日期1994年1月26日 102（e）日期1994年1月26日PCT提交1993年5月25日PCT公布。 出版物WO93 / 24460 PCT 日期：1993年12月9日，下列通式（1）表示的5-氨基喹诺酮羧酸衍生物：其中R 1表示氢原子，氨基，直链或支链烷基， 5个碳原子和含有1-5个碳原子的直链或支链烷基的烷基氨基，R2表示氢原子或具有1-5个碳原子的直链或支链烷基，X表示卤素原子，Y表示CH2 ，NH，CHR 3 NR 3，（R3表示具有1-5个碳原子的直链或支链烷基）或氧原子，Z表示氧原子或2个氢原子，或其盐，以及含有这些的抗菌剂 衍生物或盐作为活性成分。 其衍生物或盐对包括耐受性细菌的细菌性细菌表现出强的抗菌活性，并且令人满意地吸收在生物体内。

公开(公告)号：US5385900A

公开(公告)日：1995-01-31

申请号：US149134

申请日：1993-11-08

申请人： Fujiko Konno ,  Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Ryuichi Kawahara ,  Naokata Taido ,  Tadayuki Kuraishi ,  Sunao Takeda

发明人： Fujiko Konno ,  Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Ryuichi Kawahara ,  Naokata Taido ,  Tadayuki Kuraishi ,  Sunao Takeda

IPC分类号： A61K31/55 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D243/08

CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

摘要： A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in living bodies, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatments and prevention of various infectious diseases in clinics.

公开(公告)号：US5447926A

公开(公告)日：1995-09-05

申请号：US305977

申请日：1994-09-16

申请人： Fujiko Konno ,  Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Ryuichi Kawahara ,  Naokata Taido ,  Tasdayuki Kuraishi ,  Sunao Takeda

发明人： Fujiko Konno ,  Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Ryuichi Kawahara ,  Naokata Taido ,  Tasdayuki Kuraishi ,  Sunao Takeda

IPC分类号： A61K31/55 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D401/10 ,  C07D417/10

CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

摘要： A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in living bodies, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatments and prevention of various infectious diseases in clinics.

摘要翻译： 具有下式（1）的喹诺酮羧酸衍生物，其中R1是氢原子，烷基，芳烷基，可在活体中水解的酯残基，R2是氢 原子或可以被一个或两个低级烷基取代的氨基，X是氢原子或卤素原子，Y是CH 2，O，S，SO，SO 2或N-R 3，其中R 3是氢原子 或低级烷基，Z为氧原子或两个氢原子; 或其盐; 和包含该抗微生物剂的抗微生物剂。 该化合物具有优异的抗微生物活性，特别是抗革兰氏阳性微生物，因此可用于临床上各种感染性疾病的治疗和预防。

公开(公告)号：US5324735A

公开(公告)日：1994-06-28

申请号：US807856

申请日：1992-01-17

申请人： Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Masaru Matsumoto ,  Ryuichi Kawahara ,  Tatsuhiko Katori ,  Naokata Taido ,  Tadayuki Kuraishi

发明人： Akihiro Shibata ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Masaru Matsumoto ,  Ryuichi Kawahara ,  Tatsuhiko Katori ,  Naokata Taido ,  Tadayuki Kuraishi

IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D215/233 ,  A01K31/47

CPC分类号： C07D215/56 ,  C07D401/04

摘要： The present invention relates to a quinolone carboxylic acid derivative represented by the following the formula (I), ##STR1## wherein R.sub.1 is a lower alkyl group, R.sub.2 is a hydrogen atom or a lower alkyl group, R.sub.3 is a hydrogen atom or a halogen atom, R.sub.4 and R.sub.5 together form a five- or six-membered ring which may contain hetero atoms or may have substituents, provided that a compound wherein R.sub.1 is a methyl group, R.sub.2 and R.sub.3 are hydrogen atom and ##STR2## is a piperazinyl group is excluded; or a salt thereof; to an antimicrobial agent comprising the same as an effective component; and to an intermediate for producing same.

摘要翻译： PCT No.PCT / JP90 / 00425 Sec。 371日期：1992年1月17日 102（e）日期1992年1月17日PCT 1990年3月29日PCT公布。 出版物WO91 / 01308 1991年2月7日。本发明涉及由下式（I）表示的喹诺酮羧酸衍生物，其中R1是低级烷基，R2是氢原子或低级烷基 基团，R 3是氢原子或卤素原子，R 4和R 5一起形成可含有杂原子或可以具有取代基的五元或六元环，条件是其中R 1是甲基，R 2和R 3是 氢原子和是不包括的哌嗪基; 或其盐; 涉及包含其作为有效成分的抗微生物剂; 和用于生产它的中间体。

公开(公告)号：US06685958B2

公开(公告)日：2004-02-03

申请号：US09840871

申请日：2001-04-25

申请人： Samir Roy ,  Santosh Kumar Chandrasekaran ,  Katsumi Imamori ,  Takemitsu Asaoka ,  Akihiro Shibata ,  Masami Takahashi ,  Lyle M. Bowman

发明人： Samir Roy ,  Santosh Kumar Chandrasekaran ,  Katsumi Imamori ,  Takemitsu Asaoka ,  Akihiro Shibata ,  Masami Takahashi ,  Lyle M. Bowman

IPC分类号： A61F1300

CPC分类号： A61K9/0048 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/483 ,  Y10S514/912 ,  Y10S514/954 ,  Y10S514/964

摘要： The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.

摘要翻译： 本发明涉及喹诺酮羧酸制剂在治疗眼和眼周感染中的用途。 本发明还涉及包含特定喹诺酮羧酸化合物的持续释放组合物。 本发明还涉及喹诺酮羧酸组合物及其制备方法。

公开(公告)号：US06699492B2

公开(公告)日：2004-03-02

申请号：US10126513

申请日：2002-04-22

申请人： Samir Roy ,  Santosh Kumar Chandrasekaran ,  Katsumi Imamori ,  Takemitsu Asaoka ,  Akihiro Shibata ,  Masami Takahashi ,  Lyle M. Bowman

发明人： Samir Roy ,  Santosh Kumar Chandrasekaran ,  Katsumi Imamori ,  Takemitsu Asaoka ,  Akihiro Shibata ,  Masami Takahashi ,  Lyle M. Bowman

IPC分类号： A61F1300

CPC分类号： A61K9/0048 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61K47/32 ,  A61K47/38 ,  A61K47/40 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/483 ,  Y10S514/912 ,  Y10S514/954 ,  Y10S514/964

摘要： The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.

公开(公告)号：US4814436A

公开(公告)日：1989-03-21

申请号：US938883

申请日：1986-12-08

申请人： Akihiro Shibata ,  Hideaki Matsuda ,  Hidehiko Kohya ,  Tatsuhiko Katori

发明人： Akihiro Shibata ,  Hideaki Matsuda ,  Hidehiko Kohya ,  Tatsuhiko Katori

IPC分类号： C07H13/04 ,  A61K31/70 ,  A61K31/7024 ,  A61K31/7028 ,  A61P35/00 ,  C07H13/06 ,  C07H15/18 ,  C07H13/02 ,  A61K31/715

CPC分类号： C07H13/06 ,  C07H15/18

摘要： Derivatives of .alpha.,.alpha.-trehalose-6,6'-fatty acid diester having phosphoric ester groups in the molecule which are useful as a carcinostatic agent. One of the derivatives may be prepared by reacting diphenylphosphoryl chloridate with a derivative of 2,3,2',3'-tetra-O-benzyl-.alpha.,.alpha.-trehalose-6,6'-fatty acid diester. Another derivative may be obtained by substituting benzyl groups at 2,3,2',3' positions of trehalose with hydrogen atoms.

摘要翻译： 在分子中具有磷酸酯基的α，α - 海藻糖-6,6'-脂肪酸二酯的衍生物可用作制癌剂。 衍生物之一可以通过二苯基磷酰氯与2,3,2'，3'-四-O-苄基-α，α-脱水-6,6'-脂肪酸二酯的衍生物反应来制备。 通过用氢原子代替海藻糖的2,3,2'，3'位的苄基可以得到另一种衍生物。

公开(公告)号：US08832335B2

公开(公告)日：2014-09-09

申请号：US13334235

申请日：2011-12-22

申请人： Akihiro Shibata ,  Koichi Fujisaki ,  Tetsuro Kimura ,  Tatsunori Kanai ,  Haruhiko Toyama ,  Satoshi Shirai ,  Masaya Tarui ,  Hiroyoshi Haruki

发明人： Akihiro Shibata ,  Koichi Fujisaki ,  Tetsuro Kimura ,  Tatsunori Kanai ,  Haruhiko Toyama ,  Satoshi Shirai ,  Masaya Tarui ,  Hiroyoshi Haruki

IPC分类号： G06F3/00 ,  G06F5/00 ,  G06F1/32 ,  G06F9/48

CPC分类号： G06F1/3243 ,  G06F9/4812 ,  Y02D10/152 ,  Y02D10/24

摘要： According to an embodiment, a control device includes a receiving unit configured to receive an interrupt request requesting an interrupt process to be executed by a processing device that executes one or more processes; a storage unit configured to store therein the interrupt request; a determining unit configured to determine a state of the processing device; a sending unit configured to send the interrupt request to the processing device; and a control unit configured to store the interrupt request received by the receiving unit in the storage unit when the processing device is determined by the determining unit to be in an idle state in which the processing device is not executing the processes and a predetermined condition is not satisfied, and to control the sending unit to send the interrupt request stored in the storage unit to the processing device when the predetermined condition is satisfied.

摘要翻译： 根据实施例，控制装置包括：接收单元，被配置为接收请求由执行一个或多个处理的处理装置执行的中断处理的中断请求; 存储单元，被配置为在其中存储中断请求; 确定单元，被配置为确定所述处理装置的状态; 发送单元，被配置为将所述中断请求发送到所述处理装置; 以及控制单元，被配置为当所述处理设备被所述确定单元确定为处于处理设备未执行所述处理的空闲状态时，将所述接收单元接收到的所述中断请求存储在所述存储单元中，并且预定条件是 并且当满足预定条件时，控制发送单元将存储在存储单元中的中断请求发送到处理装置。

公开(公告)号：US20120246356A1

公开(公告)日：2012-09-27

申请号：US13334235

申请日：2011-12-22

申请人： Akihiro Shibata ,  Koichi Fujisaki ,  Tetsuro Kimura ,  Tatsunori Kanai ,  Haruhiko Toyama ,  Satoshi Shirai ,  Masaya Tarui ,  Hiroyoshi Haruki

发明人： Akihiro Shibata ,  Koichi Fujisaki ,  Tetsuro Kimura ,  Tatsunori Kanai ,  Haruhiko Toyama ,  Satoshi Shirai ,  Masaya Tarui ,  Hiroyoshi Haruki

IPC分类号： G06F13/24

CPC分类号： G06F1/3243 ,  G06F9/4812 ,  Y02D10/152 ,  Y02D10/24

摘要： According to an embodiment, a control device includes a receiving unit configured to receive an interrupt request requesting an interrupt process to be executed by a processing device that executes one or more processes; a storage unit configured to store therein the interrupt request; a determining unit configured to determine a state of the processing device; a sending unit configured to send the interrupt request to the processing device; and a control unit configured to store the interrupt request received by the receiving unit in the storage unit when the processing device is determined by the determining unit to be in an idle state in which the processing device is not executing the processes and a predetermined condition is not satisfied, and to control the sending unit to send the interrupt request stored in the storage unit to the processing device when the predetermined condition is satisfied.

摘要翻译： 根据实施例，控制装置包括：接收单元，被配置为接收请求由执行一个或多个处理的处理装置执行的中断处理的中断请求; 存储单元，被配置为在其中存储中断请求; 确定单元，被配置为确定所述处理装置的状态; 发送单元，被配置为将所述中断请求发送到所述处理装置; 以及控制单元，被配置为当所述处理设备被所述确定单元确定为处于处理设备未执行所述处理的空闲状态时，将所述接收单元接收到的所述中断请求存储在所述存储单元中，并且预定条件是 并且当满足预定条件时，控制发送单元将存储在存储单元中的中断请求发送到处理装置。

公开(公告)号：US20090204568A1

公开(公告)日：2009-08-13

申请号：US12364111

申请日：2009-02-02

申请人： Tsuyoshi TAKAYAMA ,  Akihiro Shibata

发明人： Tsuyoshi TAKAYAMA ,  Akihiro Shibata

IPC分类号： G06F7/06 ,  G06F17/30

CPC分类号： G11B27/36 ,  G11B27/11 ,  G11B27/329 ,  G11B2220/65

摘要： When an external recording medium connected to an interface is removed therefrom and a new external recording medium is connected to the interface, a processor selects either first file analysis information read from a memory or second file analysis information generated based on analysis of data recorded on the new external recording medium as file analysis information to be used for decoding a file stored in the new external recording medium, and the processor makes such selection based on comparison between first recording medium management information and second recording medium management information.

摘要翻译： 当连接到接口的外部记录介质被移除并且新的外部记录介质被连接到接口时，处理器选择从存储器读取的第一文件分析信息或基于记录在存储器上的数据的分析生成的第二文件分析信息 新的外部记录介质作为用于解码存储在新的外部记录介质中的文件的文件分析信息，并且处理器基于第一记录介质管理信息和第二记录介质管理信息之间的比较来进行这样的选择。