公开(公告)号：US20190071489A1

公开(公告)日：2019-03-07

申请号：US16190676

申请日：2018-11-14

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The Government of the United States, as represented by the Secretary of the Army ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Malangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  G01N33/569

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US20180291088A1

公开(公告)日：2018-10-11

申请号：US15526661

申请日：2015-11-13

申请人： The USA, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The Government of the United States as represented by the Secretary of the Army, Ft Detrick,Md ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N2333/08 ,  G01N2800/26

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virususing the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virusinfection in a subject.

公开(公告)号：US20190256579A1

公开(公告)日：2019-08-22

申请号：US16403211

申请日：2019-05-03

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Barney Graham ,  Wing-Pui Kong ,  Kayvon Modjarrad ,  Lingshu Wang ,  Wei Shi ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  John Mascola

IPC分类号： C07K16/10 ,  C07K14/005 ,  C07K14/165 ,  A61K39/215 ,  G01N33/569 ,  A61K39/12

摘要： Methods of inducing an immune response in a subject to the Middle East respiratory syndrome coronavirus (MERS-CoV) are provided. In several embodiments, the immune response is a protective immune response that inhibits or prevents MERS-CoV infection in the subject. Recombinant MERS-CoV polypeptides and nucleic acid molecules encoding same are also provided. Additionally, neutralizing antibodies that specifically bind to MERS-CoV S protein and antigen binding fragments thereof are disclosed. The antibodies and antigen binding fragments are useful, for example, in methods of detecting MERS-CoV S protein in a sample or in a subject, as well as methods of preventing and treating a MERS-CoV infection in a subject.

公开(公告)号：US10160795B2

公开(公告)日：2018-12-25

申请号：US15526661

申请日：2015-11-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The United States of America as represented by the Secretary of the Army ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/00 ,  G01N33/569

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US10273288B2

公开(公告)日：2019-04-30

申请号：US16190676

申请日：2018-11-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The United States of America, as represented by the Secretary of the Army ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  G01N33/569

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.