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公开(公告)号：US20190071489A1
公开(公告)日：2019-03-07
申请号：US16190676
申请日：2018-11-14
申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine , The Government of the United States, as represented by the Secretary of the Army , Humabs BioMed SA
发明人： Nancy Sullivan , Sabue Malangu , Davide Corti , Antonio Lanzavecchia , Barney Graham , Jean-Jacques Muyembe-Tamfun , John Trefry , Julie Ledgerwood , Daphne Stanley
IPC分类号： C07K16/10 , G01N33/569
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
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公开(公告)号：US20180291088A1
公开(公告)日：2018-10-11
申请号：US15526661
申请日：2015-11-13
申请人： The USA, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine , The Government of the United States as represented by the Secretary of the Army, Ft Detrick,Md , Humabs BioMed SA
发明人： Nancy Sullivan , Sabue Mulangu , Davide Corti , Antonio Lanzavecchia , Barney Graham , Jean-Jacques Muyembe-Tamfun , John Trefry , Julie Ledgerwood , Daphne Stanley
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/08 , G01N2800/26
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virususing the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virusinfection in a subject.
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公开(公告)号：US10160795B2
公开(公告)日：2018-12-25
申请号：US15526661
申请日：2015-11-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine , The United States of America as represented by the Secretary of the Army , Humabs BioMed SA
发明人： Nancy Sullivan , Sabue Mulangu , Davide Corti , Antonio Lanzavecchia , Barney Graham , Jean-Jacques Muyembe-Tamfun , John Trefry , Julie Ledgerwood , Daphne Stanley
IPC分类号： C07K16/10 , A61K39/00 , A61K39/395 , A61K45/06 , C07K16/00 , G01N33/569
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
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公开(公告)号：US10273288B2
公开(公告)日：2019-04-30
申请号：US16190676
申请日：2018-11-14
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine , The United States of America, as represented by the Secretary of the Army , Humabs BioMed SA
发明人： Nancy Sullivan , Sabue Mulangu , Davide Corti , Antonio Lanzavecchia , Barney Graham , Jean-Jacques Muyembe-Tamfun , John Trefry , Julie Ledgerwood , Daphne Stanley
IPC分类号： C07K16/10 , A61K39/00 , A61K39/395 , A61K39/42 , A61K45/06 , G01N33/569
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
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公开(公告)号：US11845778B2
公开(公告)日：2023-12-19
申请号：US17378587
申请日：2021-07-16
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Baoshan Zhang , Guillaume Stewart-Jones , John Mascola , Kai Xu , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
IPC分类号： A61K39/155 , C07K14/005 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/155 , A61P31/14 , C12N7/00 , C07K2319/50 , C12N2760/18634 , C12N2760/18734
摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
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公开(公告)号：US11027007B2
公开(公告)日：2021-06-08
申请号：US16578748
申请日：2019-09-23
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Institute for Research in Biomedicine
发明人： Peter Kwong , Michael Gordon Joyce , Baoshan Zhang , Yongping Yang , Peter Collins , Ursula Buchholz , Davide Corti , Antonio Lanzavecchia , Guillaume Stewart-Jones
IPC分类号： A61K39/155 , C07K14/115 , A61K39/39 , C07K14/005 , A61K48/00 , C07K14/135
摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
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公开(公告)号：US10414817B2
公开(公告)日：2019-09-17
申请号：US16025296
申请日：2018-07-02
IPC分类号： C07K14/005 , A61K38/00 , A61K39/42 , A61K39/00 , C07K16/08 , A01D34/71 , A01D34/63 , A01D101/00
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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公开(公告)号：US09796771B2
公开(公告)日：2017-10-24
申请号：US15358845
申请日：2016-11-22
IPC分类号： A61K39/00 , A01D34/71 , C07K14/005 , A61K38/00 , A61K39/42 , A01D34/63 , C07K16/08 , A01D101/00
CPC分类号： C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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公开(公告)号：US09371372B2
公开(公告)日：2016-06-21
申请号：US14973409
申请日：2015-12-17
CPC分类号： C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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公开(公告)号：US09221897B2
公开(公告)日：2015-12-29
申请号：US14096283
申请日：2013-12-04
IPC分类号： A61K39/42 , A61K39/395 , A61K39/00 , A61K39/25 , C12P21/08 , C07K16/08 , A61K38/00 , C07K14/005
CPC分类号： C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
摘要： The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
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