公开(公告)号：US20180291088A1

公开(公告)日：2018-10-11

申请号：US15526661

申请日：2015-11-13

申请人： The USA, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The Government of the United States as represented by the Secretary of the Army, Ft Detrick,Md ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N2333/08 ,  G01N2800/26

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virususing the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virusinfection in a subject.

公开(公告)号：US20190071489A1

公开(公告)日：2019-03-07

申请号：US16190676

申请日：2018-11-14

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The Government of the United States, as represented by the Secretary of the Army ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Malangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  G01N33/569

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US10160795B2

公开(公告)日：2018-12-25

申请号：US15526661

申请日：2015-11-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The United States of America as represented by the Secretary of the Army ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/00 ,  G01N33/569

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US10273288B2

公开(公告)日：2019-04-30

申请号：US16190676

申请日：2018-11-14

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine ,  The United States of America, as represented by the Secretary of the Army ,  Humabs BioMed SA

发明人： Nancy Sullivan ,  Sabue Mulangu ,  Davide Corti ,  Antonio Lanzavecchia ,  Barney Graham ,  Jean-Jacques Muyembe-Tamfun ,  John Trefry ,  Julie Ledgerwood ,  Daphne Stanley

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/395 ,  A61K39/42 ,  A61K45/06 ,  G01N33/569

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：US11845778B2

公开(公告)日：2023-12-19

申请号：US17378587

申请日：2021-07-16

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine

发明人： Baoshan Zhang ,  Guillaume Stewart-Jones ,  John Mascola ,  Kai Xu ,  Gwo-Yu Chuang ,  Li Ou ,  Peter Kwong ,  Yaroslav Tsybovsky ,  Wing-Pui Kong ,  Aliaksandr Druz ,  Davide Corti ,  Antonio Lanzavecchia

IPC分类号： A61K39/155 ,  C07K14/005 ,  A61P31/14 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00 ,  C07K2319/50 ,  C12N2760/18634 ,  C12N2760/18734

摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

公开(公告)号：US11027007B2

公开(公告)日：2021-06-08

申请号：US16578748

申请日：2019-09-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： A61K39/155 ,  C07K14/115 ,  A61K39/39 ,  C07K14/005 ,  A61K48/00 ,  C07K14/135

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20240101609A1

公开(公告)日：2024-03-28

申请号：US18537448

申请日：2023-12-12

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute for Research in Biomedicine

发明人： Baoshan Zhang ,  Guillaume Stewart-Jones ,  Tongqing Zhou ,  John Mascola ,  Kai Xu ,  Yongping Yang ,  Paul Thomas ,  Gwo-Yu Chuang ,  Li Ou ,  Peter Kwong ,  Yaroslav Tsybovsky ,  Wing-Pui Kong ,  Aliaksandr Druz ,  Davide Corti ,  Antonio Lanzavecchia

IPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00 ,  C07K2319/50 ,  C12N2760/18634 ,  C12N2760/18734

摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

公开(公告)号：US20200009243A1

公开(公告)日：2020-01-09

申请号：US16578748

申请日：2019-09-23

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  Institute for Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  C07K14/005 ,  C07K14/135

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US11786591B2

公开(公告)日：2023-10-17

申请号：US17334505

申请日：2021-05-28

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine

发明人： Peter Kwong ,  Michael Gordon Joyce ,  Baoshan Zhang ,  Yongping Yang ,  Peter Collins ,  Ursula Buchholz ,  Davide Corti ,  Antonio Lanzavecchia ,  Guillaume Stewart-Jones

IPC分类号： C07K14/005 ,  A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  C07K14/135

CPC分类号： A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  C07K14/005 ,  C07K14/135 ,  C07K2319/70 ,  C07K2319/73 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

公开(公告)号：US20220024987A1

公开(公告)日：2022-01-27

申请号：US17378587

申请日：2021-07-16

申请人： The United States of America, as represented by the Secretary, Department of Health and Human ,  Institute for Research in Biomedicine

发明人： Baoshan Zhang ,  Guillaume Stewart-Jones ,  John Mascola ,  Kai Xu ,  Gwo-Yu Chuang ,  Li Ou ,  Peter Kwong ,  Yaroslav Tsybovsky ,  Wing-Pui Kong ,  Aliaksandr Druz ,  Davide Corti ,  Antonio Lanzavecchia

IPC分类号： C07K14/005 ,  A61K39/155 ,  A61P31/14 ,  C12N7/00

摘要： Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.