公开(公告)号：US09428551B2

公开(公告)日：2016-08-30

申请号：US14278423

申请日：2014-05-15

Applicant: The University of Manchester

Inventor： Mathew Upton ,  Stephanie Sandiford

IPC: A61K38/44 ,  C07K7/08 ,  C07K14/195 ,  A61K8/64 ,  C07K17/04

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q11/00 ,  C07K14/195 ,  C07K17/04

Abstract: The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming Staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity.

Abstract translation: 本发明提供了新型的治疗性抗微生物肽，其是杀菌剂并且对由生物膜形成细菌特别是生物膜形成葡萄球菌产生的生物膜具有抑制作用。 本发明包括编码多肽的核酸，治疗细菌感染的方法，在多肽中浸渍，包被或包被的多肽中的医疗装置或植入物或假体，以及将肽递送至口腔的手段。

公开(公告)号：US20140314823A1

公开(公告)日：2014-10-23

申请号：US14278423

申请日：2014-05-15

Applicant: The University of Manchester

Inventor： Mathew Upton ,  Stephanie Sandiford

IPC: C07K7/08 ,  A61K8/64 ,  C07K17/04

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q11/00 ,  C07K14/195 ,  C07K17/04

Abstract: The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity.

Abstract translation: 本发明提供了新型的治疗性抗微生物肽，其为杀菌剂并且对生物膜形成细菌特别是生物膜形成葡萄球菌属细菌产生的生物膜具有抑制作用。 本发明包括编码多肽的核酸，治疗细菌感染的方法，在多肽中浸渍，包被或包被的多肽中的医疗装置或植入物或假体，以及将肽递送至口腔的手段。