公开(公告)号：US20130266508A1

公开(公告)日：2013-10-10

申请号：US13441961

申请日：2012-04-09

申请人： Tsai-Yueh Luo ,  Cheng-Liang Peng ,  Ming-Jium Shieh ,  Ying-Hsia Shih ,  Chung-Hsin Yeh ,  I-Chung Tang

发明人： Tsai-Yueh Luo ,  Cheng-Liang Peng ,  Ming-Jium Shieh ,  Ying-Hsia Shih ,  Chung-Hsin Yeh ,  I-Chung Tang

IPC分类号： A61K51/12 ,  A61K31/704 ,  A61P35/00 ,  A61K31/4745 ,  A61K51/00 ,  A61K47/34 ,  A61K9/00 ,  A61K31/337

CPC分类号： A61K47/34 ,  A61K9/06 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/704 ,  A61K45/06 ,  A61K51/1213 ,  A61K2300/00

摘要： A thermosensitive hydrogel for coating radioisotopes and chemotherapeutic agents to treat cancer and a method for preparing the same are revealed. The anticancer drugs such as radiopharmaceuticals or chemotherapeutic agents are coated with the hydrogel formed by PCL-PEG-PCL. By the feature of the hydrogel body that changes from liquid phase at low storage temperature to gel form at body temperature, not only the anticancer drugs can be injected into the human body and reaching the treatment site smoothly but the treatment time of brachytherapy is also extended. Thus the side effects of cancer therapy are significantly reduced.

摘要翻译： 揭示了用于涂覆放射性同位素和化学治疗剂以治疗癌症的热敏水凝胶及其制备方法。 放射性药物或化学治疗剂等抗癌药物由PCL-PEG-PCL形成的水凝胶包被。 由于水凝胶体的特点是在低温储存温度下从液相变为凝胶状态，不仅可以将抗癌药物注入人体并顺利到达治疗部位，而且近距离放射治疗的治疗时间也延长 。 因此，癌症治疗的副作用显着降低。

公开(公告)号：US08367811B2

公开(公告)日：2013-02-05

申请号：US12263573

申请日：2008-11-03

申请人： Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

发明人： Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC分类号： C07F13/00

CPC分类号： A61K51/065 ,  C08B37/003 ,  C08L5/08

摘要： A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

摘要翻译： 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。

公开(公告)号：US20100111860A1

公开(公告)日：2010-05-06

申请号：US12263573

申请日：2008-11-03

申请人： Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

发明人： Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC分类号： A61K51/06 ,  C08B37/08 ,  A61P35/00

CPC分类号： A61K51/065 ,  C08B37/003 ,  C08L5/08

摘要： A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

摘要翻译： 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。

公开(公告)号：US08048405B2

公开(公告)日：2011-11-01

申请号：US12354815

申请日：2009-01-16

申请人： Tsai-Yueh Luo ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

发明人： Tsai-Yueh Luo ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

IPC分类号： A61K49/00

CPC分类号： A61K51/0478 ,  A61K49/0438

摘要： A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

摘要翻译： 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物（188Re-MN / Lipiodol混合物），然后溶于Lipiodol中。 此外，TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征，通过注射施用放射性混合物来治疗肝癌，从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌，乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物，水凝胶，脂质体，胶束或其他纳米颗粒混合，形成多功能治疗方式。

公开(公告)号：US20100183508A1

公开(公告)日：2010-07-22

申请号：US12354815

申请日：2009-01-16

申请人： Tsai-Yueh LUO ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

发明人： Tsai-Yueh LUO ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

IPC分类号： A61K51/04 ,  A61P35/00

CPC分类号： A61K51/0478 ,  A61K49/0438

摘要： A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

摘要翻译： 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物（188Re-MN / Lipiodol混合物），然后溶解于Lipiodol中。 此外，TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征，通过注射施用放射性混合物来治疗肝癌，从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌，乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物，水凝胶，脂质体，胶束或其他纳米颗粒混合，形成多功能治疗方式。