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公开(公告)号:US07091368B2
公开(公告)日:2006-08-15
申请号:US10532205
申请日:2003-11-17
申请人: Ulrike Maier , Martin Jochen Klatt
发明人: Ulrike Maier , Martin Jochen Klatt
IPC分类号: C11B3/10
CPC分类号: C07D339/04
摘要: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.
摘要翻译: 本发明涉及一种纯化硫辛酸的方法,其包括将硫辛酸溶液加入至少0.1倍量的吸附剂,基于待纯化的硫辛酸的质量,随后除去吸附剂。 以这种方式可以提供低聚物含量低于1重量%,例如0.1-1重量%的外消旋或非芳香硫辛酸。
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公开(公告)号:US06297404B1
公开(公告)日:2001-10-02
申请号:US09598245
申请日:2000-06-21
IPC分类号: C07C4532
CPC分类号: B01J31/2243 , B01J2531/0252 , B01J2531/72 , B01J2531/90 , C07C45/34 , C07C49/603
摘要: The present invention relates to a process for preparing 3,5,5-trimethylcyclohex-2-ene-1,4-dione (oxoisophorone; OIP) by oxidation of 3,5,5-trimethylcyclohex-3-en-1-one (&bgr;-isophorone, &bgr;-IP) with molecular oxygen in the presence of a solvent, of a base and of a transition metal salen derivative as catalyst and of an additive.
摘要翻译: 本发明涉及通过3,5,5-三甲基环己-3-烯-1-酮的氧化制备3,5,5-三甲基环己-2-烯-1,4-二酮(氧合异佛尔酮; OIP)的方法 β-异佛尔酮,β-IP)与分子氧在溶剂,碱和过渡金属salen衍生物作为催化剂和添加剂的存在下反应。
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公开(公告)号:US06906210B2
公开(公告)日:2005-06-14
申请号:US10343034
申请日:2001-07-24
IPC分类号: A61K31/20 , A61P3/10 , C07B53/00 , C07C303/38 , C07C309/66 , C07C319/08 , C07C319/18 , C07C319/28 , C07C321/04 , C07C323/52 , C07D339/04 , C07B45/00
CPC分类号: C07D339/04 , C07C319/18 , C07C321/04 , C07C323/52
摘要: Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of or its stereoisomer, where Ms is SO2—R′ and R and R′ independently of one another is [sic] C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.
摘要翻译: 用于制备R-硫辛酸或S-硫辛酸的方法包括选自以下的方法步骤:a)蒸馏二氢硫辛酸,b)其反应或其立体异构体,其中Ms为SO 2 -R' 且R和R'彼此独立地是C 1 -C 6 - C 6 - 烷基,C 3 -C 8 环烷基,C 3 -C 8 - 环烷基烷基,芳基或芳烷基,与硫化钠和硫在乙醇中并与络合氢化物反应,(c) 在9至10的pH下用有机溶剂萃取R-二氢硫辛酸或S-二氢硫辛酸的质子溶液,或(d)用有机溶剂从质子溶液中萃取R-二氢硫辛酸或S-二氢硫辛酸 pH为4至5,或步骤(a)至(d)中的一种或多种的组合,以及制备二氢硫辛酸和化合物1,6,8 [空白]辛三醇的方法。
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公开(公告)号:US06300521B1
公开(公告)日:2001-10-09
申请号:US09598243
申请日:2000-06-21
IPC分类号: C07C4500
CPC分类号: B01J31/2243 , B01J2531/0252 , B01J2531/72 , B01J2531/90 , C07C45/34 , C07C49/603
摘要: The present invention relates to a process for preparing 3,5, 5-trimethylcyclohex -2-ene-1,4-dione (oxoisophorone; OIP) by oxidation of 3,5,5-trimethylcyclohex-3-en-1-one (&bgr;-isophorone, &bgr;-IP) with molecular oxygen in the presence of a solvent, of a base and of a manganese salen derivative as catalyst.
摘要翻译: 本发明涉及通过氧化3,5,5-三甲基环己-3-烯-1-酮来制备3,5,5-三甲基环己-2-烯-1,4-二酮(氧合异佛尔酮; OIP)的方法( β-异佛尔酮,β-IP)与分子氧在溶剂,碱和锰salen衍生物作为催化剂存在下反应。
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公开(公告)号:US06441024B1
公开(公告)日:2002-08-27
申请号:US09743920
申请日:2001-01-17
申请人: Martin Jochen Klatt , Markus Niebel , Joachim Paust , Jens Rieger
发明人: Martin Jochen Klatt , Markus Niebel , Joachim Paust , Jens Rieger
IPC分类号: A61K31385
CPC分类号: C07D339/04
摘要: In the 2 &THgr; diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 &THgr;=23°.
摘要翻译: 在2&THgr 对映体纯的结晶(R) - 或(S) - 硫辛酸的衍射图,在13°至30°范围内最强反射线为2°时= 23°。
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公开(公告)号:US06359165B1
公开(公告)日:2002-03-19
申请号:US09407283
申请日:1999-09-29
申请人: Rainer Stürmer , Martin Jochen Klatt , Armin Börmer , Jens Holz , Gudrun Voss
发明人: Rainer Stürmer , Martin Jochen Klatt , Armin Börmer , Jens Holz , Gudrun Voss
IPC分类号: C07C6974
CPC分类号: C07C67/31 , C07C69/675
摘要: Enantiomerically pure &bgr;-hydroxy esters are prepared by a process in which &bgr;-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I where B=a bridging link with 1-5 carbon atoms between the two phosphorus atoms, R1=H, C1-C6-alkyl, aryl, alkylaryl or SiR23, R2=alkyl or aryl, m=0 or 1, R3=H or OR4, and R4=R1, with the proviso that if m=1 then R3=H and if m=0 then R3 ≠ H.
摘要翻译: 对映异构体纯的β-羟基酯是通过一种方法制备的,其中β-酮酯与式ⅠRuX2的催化剂,其中X是卤素,乙酸酯,烯丙基,甲代烯丙基,2-苯基烯丙基,高氯酸,三氟乙酸,四氟硼酸, 六氟锑酸盐,六氟磷酸盐,六氟砷酸盐或三氯乙酸盐,L是式I的二齿磷脂,其中B =两个磷原子之间具有1-5个碳原子的桥连,R1 = H,C1-C6-烷基,芳基,烷基芳基或SiR23, R2 =烷基或芳基,m = 0或1,R3 = H或OR4,R4 = R1,条件是如果m = 1,则R3 = H,如果m = 0,则R3 <
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公开(公告)号:US07109362B2
公开(公告)日:2006-09-19
申请号:US10432455
申请日:2001-11-29
IPC分类号: C07B45/00 , A61K31/095 , C07D339/04
CPC分类号: C07D339/04
摘要: The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising(a) reaction of where MS is SO2—R′ and R and R′ independently of one another are C1–C6-alkyl, C3–C8-cycloalkyl, C3–C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.
摘要翻译: 本发明涉及制备R-和S-硫辛酸和R-和S-二氢硫辛酸的方法,其包括(a)其中MS为SO 2 -R'和R和 R'彼此独立地是C 1 -C 6 - 烷基,C 3 -C 8 - 环烷基 C 3 -C 8 - 环烷基烷基,芳基或芳烷基,与硫化钠和硫在甲醇中反应。 本发明特别涉及制备纯R-或S-二氢硫辛酸的方法,其可直接使用或进一步加工得到R-和S-硫辛酸。 该方法还用于生产药物。 本发明还涉及硫化钠三水合物和硫在甲醇中的溶液,所述硫以超过硫化钠三水合物的摩尔量存在,以及包含根据本发明的溶液的试剂盒。
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8.
公开(公告)号:US06887894B2
公开(公告)日:2005-05-03
申请号:US09897922
申请日:2001-07-05
申请人: Klaus Krämer , Martin Jochen Klatt
发明人: Klaus Krämer , Martin Jochen Klatt
IPC分类号: A23K1/16 , A23L1/30 , A23L1/304 , A61K8/00 , A61K8/20 , A61K8/21 , A61K8/23 , A61K8/24 , A61K8/30 , A61K8/36 , A61K8/365 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/58 , A61K31/20 , A61K31/381 , A61K33/00 , A61K33/06 , A61K33/14 , A61K33/24 , A61K33/42 , A61P1/00 , A61P3/00 , A61P3/02 , A61P3/10 , A61P13/00 , A61P13/12 , A61P31/18 , A61P35/00 , A61P43/00 , A61Q90/00 , C07D339/04 , A61K31/385 , C07D327/00
CPC分类号: A61K33/00 , A61K31/385 , A61K2300/00
摘要: The use of α-lipoic acid or α-dihydrolipoic acid for increasing the bioavailability of mineral salts, the use of α-lipoic acid or α-dihydrolipoic acid in combination with metal salts, in particular the use of metal α-lipoates, metal α-dihydrolipoates or metal-α-lipoic acid complexes, in particular in mineral preparations or drugs and the metal α-lipoates, metal α-dihydrolipoates or metal-α-lipoic acid complexes themselves are described.
摘要翻译: 使用α-硫辛酸或α-二氢硫辛酸来增加矿物盐的生物利用度,使用α-硫辛酸或α-二氢硫辛酸与金属盐组合使用,特别是使用金属α-脂肪酸盐,金属α - 二氢油脂酸盐或金属α-硫辛酸络合物,特别是矿物制剂或药物和金属α-脂肪酸盐,金属α-二氢油脂酸盐或金属α-硫辛酸络合物本身。
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公开(公告)号:US06620964B2
公开(公告)日:2003-09-16
申请号:US10307333
申请日:2002-12-02
IPC分类号: C07C6966
CPC分类号: C07D339/04 , C07C67/31 , C07C69/675
摘要: A description is given of a process for preparing dihydroxycarboxylic esters and of an overall process for preparing R-(+)-&agr;-lipoic acid.
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