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    Method for producing lipoic acid and dihydrolipoic acid
    3.
    发明授权
    Method for producing lipoic acid and dihydrolipoic acid 失效
    硫辛酸和二氢硫辛酸的制备方法

    公开(公告)号：US06906210B2

    公开(公告)日：2005-06-14

    申请号：US10343034

    申请日：2001-07-24

    申请人： Martin Jochen Klatt ,  Markus Niebel ,  Joachim Paust

    发明人： Martin Jochen Klatt ,  Markus Niebel ,  Joachim Paust

    IPC分类号： A61K31/20 ,  A61P3/10 ,  C07B53/00 ,  C07C303/38 ,  C07C309/66 ,  C07C319/08 ,  C07C319/18 ,  C07C319/28 ,  C07C321/04 ,  C07C323/52 ,  C07D339/04 ,  C07B45/00

    CPC分类号： C07D339/04 ,  C07C319/18 ,  C07C321/04 ,  C07C323/52

    摘要： Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of  or its stereoisomer, where Ms is SO2—R′ and R and R′ independently of one another is [sic] C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.

    摘要翻译： 用于制备R-硫辛酸或S-硫辛酸的方法包括选自以下的方法步骤：a）蒸馏二氢硫辛酸，b）其反应或其立体异构体，其中Ms为SO 2 -R' 且R和R'彼此独立地是C 1 -C 6 - C 6 - 烷基，C 3 -C 8 环烷基，C 3 -C 8 - 环烷基烷基，芳基或芳烷基，与硫化钠和硫在乙醇中并与络合氢化物反应，（c） 在9至10的pH下用有机溶剂萃取R-二氢硫辛酸或S-二氢硫辛酸的质子溶液，或（d）用有机溶剂从质子溶液中萃取R-二氢硫辛酸或S-二氢硫辛酸 pH为4至5，或步骤（a）至（d）中的一种或多种的组合，以及制备二氢硫辛酸和化合物1,6,8 [空白]辛三醇的方法。

    Method for the purification of liponic acid
    4.
    发明授权
    Method for the purification of liponic acid 失效
    脂肪酸纯化方法

    公开(公告)号：US07091368B2

    公开(公告)日：2006-08-15

    申请号：US10532205

    申请日：2003-11-17

    申请人： Ulrike Maier ,  Martin Jochen Klatt

    发明人： Ulrike Maier ,  Martin Jochen Klatt

    IPC分类号： C11B3/10

    CPC分类号： C07D339/04

    摘要： The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

    摘要翻译： 本发明涉及一种纯化硫辛酸的方法，其包括将硫辛酸溶液加入至少0.1倍量的吸附剂，基于待纯化的硫辛酸的质量，随后除去吸附剂。 以这种方式可以提供低聚物含量低于1重量％，例如0.1-1重量％的外消旋或非芳香硫辛酸。

    Asymmetric hydrogenation of &bgr;-keto esters
    6.
    发明授权
    Asymmetric hydrogenation of &bgr;-keto esters 失效
    β-酮酯的不对称氢化

    公开(公告)号：US06359165B1

    公开(公告)日：2002-03-19

    申请号：US09407283

    申请日：1999-09-29

    申请人： Rainer Stürmer ,  Martin Jochen Klatt ,  Armin Börmer ,  Jens Holz ,  Gudrun Voss

    发明人： Rainer Stürmer ,  Martin Jochen Klatt ,  Armin Börmer ,  Jens Holz ,  Gudrun Voss

    IPC分类号： C07C6974

    CPC分类号： C07C67/31 ,  C07C69/675

    摘要： Enantiomerically pure &bgr;-hydroxy esters are prepared by a process in which &bgr;-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I  where B=a bridging link with 1-5 carbon atoms between the two phosphorus atoms, R1=H, C1-C6-alkyl, aryl, alkylaryl or SiR23, R2=alkyl or aryl, m=0 or 1, R3=H or OR4, and R4=R1, with the proviso that if m=1 then R3=H and if m=0 then R3 ≠ H.

    摘要翻译： 对映异构体纯的β-羟基酯是通过一种方法制备的，其中β-酮酯与式ⅠRuX2的催化剂，其中X是卤素，乙酸酯，烯丙基，甲代烯丙基，2-苯基烯丙基，高氯酸，三氟乙酸，四氟硼酸， 六氟锑酸盐，六氟磷酸盐，六氟砷酸盐或三氯乙酸盐，L是式I的二齿磷脂，其中B =两个磷原子之间具有1-5个碳原子的桥连，R1 = H，C1-C6-烷基，芳基，烷基芳基或SiR23， R2 =烷基或芳基，m = 0或1，R3 = H或OR4，R4 = R1，条件是如果m = 1，则R3 = H，如果m = 0，则R3 <

    Process for the preparation of lipoic acid and dihydrolipoic acid
    7.
    发明授权
    Process for the preparation of lipoic acid and dihydrolipoic acid 失效
    制备硫辛酸和二氢硫辛酸的方法

    公开(公告)号：US07109362B2

    公开(公告)日：2006-09-19

    申请号：US10432455

    申请日：2001-11-29

    申请人： Martin Jochen Klatt ,  Markus Niebel ,  Joachim Paust

    发明人： Martin Jochen Klatt ,  Markus Niebel ,  Joachim Paust

    IPC分类号： C07B45/00 ,  A61K31/095 ,  C07D339/04

    CPC分类号： C07D339/04

    摘要： The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising(a) reaction of where MS is SO2—R′ and R and R′ independently of one another are C1–C6-alkyl, C3–C8-cycloalkyl, C3–C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to give R- and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

    摘要翻译： 本发明涉及制备R-和S-硫辛酸和R-和S-二氢硫辛酸的方法，其包括（a）其中MS为SO 2 -R'和R和 R'彼此独立地是C 1 -C 6 - 烷基，C 3 -C 8 - 环烷基 C 3 -C 8 - 环烷基烷基，芳基或芳烷基，与硫化钠和硫在甲醇中反应。 本发明特别涉及制备纯R-或S-二氢硫辛酸的方法，其可直接使用或进一步加工得到R-和S-硫辛酸。 该方法还用于生产药物。 本发明还涉及硫化钠三水合物和硫在甲醇中的溶液，所述硫以超过硫化钠三水合物的摩尔量存在，以及包含根据本发明的溶液的试剂盒。