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1.发明授权Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors 有权含二芳基胺的化合物和组合物，以及它们作为c-kit受体调节剂的用途公开(公告)号：US07638523B2
公开(公告)日：2009-12-29
申请号：US11933030
申请日：2007-10-31
申请人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
发明人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
IPC分类号： A61K31/505 , A61K31/506 , A61P19/02 , A61P37/08 , A61P9/02 , A61P17/06 , A61P1/04 , A61P1/16 , A61P25/20 , C07D239/42 , C07D403/10 , C07D403/14
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
摘要翻译： 本文描述的是包括二芳基胺结构特征的化合物。 本文还描述了制备这种化合物的方法，使用这些化合物调节c-kit受体的活性的方法，以及包含这些化合物的药物组合物和药物。 本文还描述了使用这些化合物，药物组合物和药物来治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或病症的方法。
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2.发明授权公开(公告)号：US07563894B2
公开(公告)日：2009-07-21
申请号：US11932945
申请日：2007-10-31
申请人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
发明人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
IPC分类号： C07D403/10 , C07D403/14 , C07D239/42 , A61K31/505
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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3.发明申请公开(公告)号：US20080167308A1
公开(公告)日：2008-07-10
申请号：US11932945
申请日：2007-10-31
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Juliet Nabakka , Jon Loren , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Juliet Nabakka , Jon Loren , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： A61K31/5377 , C07D239/42 , A61K31/505 , A61K31/506 , C12N9/12 , C07D403/12 , C07D413/12
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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4.发明申请公开(公告)号：US20090264649A1
公开(公告)日：2009-10-22
申请号：US12475266
申请日：2009-05-29
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： C07D403/12 , C07D239/42 , C07D413/12 , C07D417/12
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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5.发明申请DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS 有权含二氨基苯胺的化合物和组合物及其作为C-kit接受体的调节剂公开(公告)号：US20090012094A1
公开(公告)日：2009-01-08
申请号：US11933030
申请日：2007-10-31
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： A61K31/496 , C07D239/42 , C07D407/14 , C12N9/12 , A61K31/505
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
摘要翻译： 本文描述的是包括二芳基胺结构特征的化合物。 本文还描述了制备这种化合物的方法，使用这些化合物调节c-kit受体的活性的方法，以及包含这些化合物的药物组合物和药物。 本文还描述了使用这些化合物，药物组合物和药物来治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或病症的方法。
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6.发明申请公开(公告)号：US20080139559A1
公开(公告)日：2008-06-12
申请号：US11933056
申请日：2007-10-31
申请人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
发明人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
IPC分类号： A61K31/5377 , A61K31/506 , C12N9/12 , A61K31/505
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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7.发明授权公开(公告)号：US07592349B2
公开(公告)日：2009-09-22
申请号：US11933056
申请日：2007-10-31
申请人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
发明人： Valentina Molteni , Shuli You , Juliet Nabakka , Yi Liu , Xiaolin Li , Donatella Chianelli , Jon Loren , Xiaodong Liu , Shifeng Pan , Donald S. Karanewsky , Pascal Furet , Vito Guagnano
IPC分类号： A61K31/505 , A61K31/506 , C07D239/42 , C07D403/04 , C07D403/14 , A61P35/00
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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8.发明申请DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS 审中-公开含二氨基苯胺的化合物和组合物及其作为C-kit接受体的调节剂公开(公告)号：US20080139597A1
公开(公告)日：2008-06-12
申请号：US11932986
申请日：2007-10-31
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiaodong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： A61K31/506 , A61P43/00
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
摘要翻译： 本文描述的是包括二芳基胺结构特征的化合物。 本文还描述了制备这种化合物的方法，使用这些化合物调节c-kit受体的活性的方法，以及包含这些化合物的药物组合物和药物。 本文还描述了使用这些化合物，药物组合物和药物来治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或病症的方法。
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9.发明授权公开(公告)号：US07514447B2
公开(公告)日：2009-04-07
申请号：US11535455
申请日：2006-09-26
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiadong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiadong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： C07D239/42 , C07D403/10 , C07D403/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
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公开(公告)号：US20120202782A1
公开(公告)日：2012-08-09
申请号：US13445644
申请日：2012-04-12
申请人： Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
发明人： Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
IPC分类号： A61K31/536 , A61K31/551 , A61K31/496 , A61K31/4985 , C07D487/08 , A61K31/538 , C07D401/14 , A61K31/517 , A61P37/06 , A61P29/00 , A61P19/02 , A61P17/06 , A61P7/06 , A61P35/00 , C07D413/14
CPC分类号： C07D413/14 , C07D413/02
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的B细胞活性有关的疾病或病症的方法，特别是涉及肌醇1,4异常活化的疾病或病症， 5-三磷酸3-激酶B（ITPKb）。
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