公开(公告)号：US20150238656A1

公开(公告)日：2015-08-27

申请号：US14610902

申请日：2015-01-30

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Giuseppe Orlando ,  Shay Soker

IPC: A61L27/36 ,  A61L27/54 ,  A61L27/38

CPC classification number: A61L27/3633 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/256 ,  A61L2300/42 ,  A61L2430/26 ,  A61L2430/28 ,  A61L2430/40

Abstract: Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues, thereby providing an approach to needed organs or tissues.

Abstract translation: 提供体外和体内脱细胞化器官和组织的方法，以及维持器官和组织框架的方法以及使器官和组织接收的方法，从而提供所需器官或组织的方法。

公开(公告)号：US11648335B2

公开(公告)日：2023-05-16

申请号：US14610902

申请日：2015-01-30

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Giuseppe Orlando ,  Shay Soker

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54

CPC classification number: A61L27/3633 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/256 ,  A61L2300/42 ,  A61L2430/26 ,  A61L2430/28 ,  A61L2430/40

Abstract: Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues, thereby providing an approach to needed organs or tissues.

公开(公告)号：US20220305175A1

公开(公告)日：2022-09-29

申请号：US17607995

申请日：2020-05-08

Applicant: Wake Forest University Health Sciences

Inventor： Giuseppe Orlando ,  Riccardo Tamburrini

IPC: A61L27/36 ,  A61L27/38 ,  C12N5/00 ,  A61P3/10

Abstract: Provided herein are improved methods of decellularizing pancreas and other tissues. The methods according to some embodiments are water-based and may be detergent-free, allowing for the production of acellular scaffolds whereby the matrisome is better preserved. Compositions comprising decellularized tissue and methods of use thereof are also provided.

公开(公告)号：US20230310708A1

公开(公告)日：2023-10-05

申请号：US18170669

申请日：2023-02-17

Applicant: Wake Forest University Health Sciences

Inventor： Giuseppe Orlando ,  Shay Soker

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54

CPC classification number: A61L27/3633 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/256 ,  A61L2300/42 ,  A61L2430/26 ,  A61L2430/28 ,  A61L2430/40

Abstract: Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues, thereby providing an approach to needed organs or tissues.