公开(公告)号：US06262333B1

公开(公告)日：2001-07-17

申请号：US09328111

申请日：1999-06-08

申请人： Wilson O. Endege ,  Kathleen E. Steinmann ,  Jon H. Astle ,  Christopher C. Burgess ,  Steven E. Bushnell ,  Eddie Carroll, III ,  Theodore J. Catino ,  Adnan Derti ,  Donna M. Ford ,  Marcia E. Lewis ,  John E. Monahan ,  Robert Schlegel

发明人： Wilson O. Endege ,  Kathleen E. Steinmann ,  Jon H. Astle ,  Christopher C. Burgess ,  Steven E. Bushnell ,  Eddie Carroll, III ,  Theodore J. Catino ,  Adnan Derti ,  Donna M. Ford ,  Marcia E. Lewis ,  John E. Monahan ,  Robert Schlegel

IPC分类号： A01K6700

CPC分类号： C07K14/47 ,  A61K38/00

摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs. and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly colon cancer cell lines and/or tissue.

摘要翻译： 本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。 本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体。 和抗体。 已经发现目标核酸在肿瘤细胞，特别是结肠癌细胞系和/或组织中是差异调节的。

公开(公告)号：US06262334B1

公开(公告)日：2001-07-17

申请号：US09385982

申请日：1999-08-30

申请人： Wilson O. Endege ,  Kathleen E. Steinmann ,  Jon H. Astle ,  Christopher C. Burgess ,  Eddie Carroll, III ,  Theodore J. Catino ,  Poornima Dwivedi ,  Donna M. Ford ,  Marcia E. Lewis ,  Gary A. Molino ,  John E. Monahan ,  Robert Schlegel

发明人： Wilson O. Endege ,  Kathleen E. Steinmann ,  Jon H. Astle ,  Christopher C. Burgess ,  Eddie Carroll, III ,  Theodore J. Catino ,  Poornima Dwivedi ,  Donna M. Ford ,  Marcia E. Lewis ,  Gary A. Molino ,  John E. Monahan ,  Robert Schlegel

IPC分类号： A01K6700

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.

摘要翻译： 本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。 本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。 已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

公开(公告)号：US06476207B1

公开(公告)日：2002-11-05

申请号：US09328475

申请日：1999-06-09

申请人： Jimmy Zhang ,  Jon H. Astle ,  Eddie Carroll, III ,  Wilson O. Endege ,  Donna M. Ford ,  John E. Monahan ,  Robert Schlegel ,  Kathleen E. Steinmann

发明人： Jimmy Zhang ,  Jon H. Astle ,  Eddie Carroll, III ,  Wilson O. Endege ,  Donna M. Ford ,  John E. Monahan ,  Robert Schlegel ,  Kathleen E. Steinmann

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/57434 ,  G01N33/57488

摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The invention further relates to polynucleotides differentially expressed in prostate cancer.

摘要翻译： 本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。 本发明还涉及与基因和蛋白质相关的诊断和治疗剂，包括探针，反义构建体和抗体。 本发明还涉及在前列腺癌中差异表达的多核苷酸。

公开(公告)号：US20080131889A1

公开(公告)日：2008-06-05

申请号：US11799463

申请日：2007-04-30

申请人： Jon H. Astle ,  Christopher C. Burgess ,  Theodore J. Catino ,  Poornima Dwivedi ,  Marcia E. Lewis ,  Gary A. Molino ,  Susan H. Myerow ,  Arunthathi Thiagalingam

发明人： Jon H. Astle ,  Christopher C. Burgess ,  Theodore J. Catino ,  Poornima Dwivedi ,  Marcia E. Lewis ,  Gary A. Molino ,  Susan H. Myerow ,  Arunthathi Thiagalingam

IPC分类号： C12Q1/68 ,  G01N33/567 ,  G01N33/574

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57419

摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.

公开(公告)号：US07211398B2

公开(公告)日：2007-05-01

申请号：US10280403

申请日：2002-10-25

申请人： Jon H. Astle ,  Christopher C. Burgess ,  Theodore J. Catino ,  Poornima Dwivedi ,  Marcia E. Lewis ,  Gary A. Molino ,  Susan H. Myerow ,  Arunthathi Thiagalingam ,  Stephen Thibodeau ,  Lawrence J. Burgart ,  Lisa Allyn Boardman

发明人： Jon H. Astle ,  Christopher C. Burgess ,  Theodore J. Catino ,  Poornima Dwivedi ,  Marcia E. Lewis ,  Gary A. Molino ,  Susan H. Myerow ,  Arunthathi Thiagalingam ,  Stephen Thibodeau ,  Lawrence J. Burgart ,  Lisa Allyn Boardman

IPC分类号： G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57419

摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.

摘要翻译： 本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。 本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。 已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。

公开(公告)号：US07258973B2

公开(公告)日：2007-08-21

申请号：US09907479

申请日：2001-07-17

申请人： Jon H. Astle ,  Christopher C. Burgess ,  Theodore J. Catino ,  Poornima Dwivedi ,  Marcia E. Lewis ,  Gary A. Molino ,  Susan H. Myerow ,  Arunthathi Thiagalingam ,  Stephen Thibodeau ,  Lawrence J. Burgart ,  Lisa Allyn Boardman

发明人： Jon H. Astle ,  Christopher C. Burgess ,  Theodore J. Catino ,  Poornima Dwivedi ,  Marcia E. Lewis ,  Gary A. Molino ,  Susan H. Myerow ,  Arunthathi Thiagalingam ,  Stephen Thibodeau ,  Lawrence J. Burgart ,  Lisa Allyn Boardman

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57419

摘要： This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be differentially regulated in tumor cells, particularly in colon cancer tissue.

摘要翻译： 本发明涉及新的人类基因，由基因表达的蛋白质以及蛋白质的变体。 本发明还涉及与基因和蛋白质相关的诊断测定和治疗剂，包括探针，反义构建体和抗体。 已经发现目标核酸在肿瘤细胞，特别是结肠癌组织中是差异调节的。