利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.023 秒)

    Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
    1.
    发明授权
    Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus 有权

    公开(公告)号：US10703743B2

    公开(公告)日：2020-07-07

    申请号：US16037678

    申请日：2018-07-17

    申请人： YALE UNIVERSITY

    发明人： David Spiegel ,  Christopher Parker

    IPC分类号： C07D405/14 ,  A61K31/496 ,  A61K45/06 ,  A61K9/00

    摘要： The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.

    CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE
    2.
    发明申请
    CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE 有权
    细胞毒素递送分子靶向HIV（CDM-HS），抗人类免疫缺陷病毒的细胞毒活性及其使用方法

    公开(公告)号：US20150087609A1

    公开(公告)日：2015-03-26

    申请号：US14396956

    申请日：2013-03-15

    申请人： YALE UNIVERSITY

    发明人： David Spiegel ,  Christopher Parker

    IPC分类号： C07H15/26 ,  A61K45/06 ,  A61K31/706

    CPC分类号： C07H15/26 ,  A61K31/67 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/706 ,  A61K45/06 ,  A61K47/55 ,  A61K47/60 ,  C07D405/14 ,  A61K2300/00

    摘要： The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.

    摘要翻译： 本发明涉及新的双功能化合物和用于治疗HIV感染的方法。 通常称为CDM-Hs的双功能小分子通过正交途径通过抑制gp120-CD4相互作用，并通过将细胞毒素部分引入到表达gp120的细胞中起作用，从而引起细胞死亡并预防细胞感染和HIV扩散。 显示CDM-Hs与CD4的gp120和gp-120表达细胞竞争性地结合，并且这些化合物引起HIV感染细胞的细胞死亡，从而降低病毒感染性。 本文描述了化合物和方法。

    BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS
    3.
    发明申请
    BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS 有权

    公开(公告)号：US20220089579A1

    公开(公告)日：2022-03-24

    申请号：US17470393

    申请日：2021-09-09

    申请人： YALE UNIVERSITY

    发明人： David Spiegel ,  Christopher Parker

    IPC分类号： C07D405/14 ,  A61K31/496 ,  A61K45/06 ,  A61K9/00

    摘要： The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.

    BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS
    5.
    发明申请
    BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS 审中-公开

    公开(公告)号：US20190002447A1

    公开(公告)日：2019-01-03

    申请号：US16037678

    申请日：2018-07-17

    申请人： YALE UNIVERSITY

    发明人： David Spiegel ,  Christopher Parker

    IPC分类号： C07D405/14 ,  A61K9/00 ,  A61K45/06 ,  A61K31/496

    摘要： The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.

    Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
    6.
    发明授权
    Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus 有权

    公开(公告)号：US10030008B2

    公开(公告)日：2018-07-24

    申请号：US15379969

    申请日：2016-12-15

    申请人： YALE UNIVERSITY

    发明人： David Spiegel ,  Christopher Parker

    IPC分类号： C07D405/14 ,  A61K31/496 ,  A61K9/00 ,  A61K45/06

    摘要： The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.

    Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the Human Immunodeficiency Virus
    8.
    发明授权
    Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the Human Immunodeficiency Virus 有权

    公开(公告)号：US11136316B2

    公开(公告)日：2021-10-05

    申请号：US16894362

    申请日：2020-06-05

    申请人： YALE UNIVERSITY

    发明人： David Spiegel ,  Christopher Parker

    IPC分类号： C07D405/14 ,  A61K31/496 ,  A61K45/06 ,  A61K9/00

    摘要： The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.