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    PLANT EXPRESSING ANIMAL MILK PROTEINS
    1.
    发明申请
    PLANT EXPRESSING ANIMAL MILK PROTEINS 有权

    公开(公告)号：US20230034320A1

    公开(公告)日：2023-02-02

    申请号：US17489824

    申请日：2021-09-30

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph AHARONI ,  Aviel EVEN ,  Dan EVEN

    IPC: C12N15/82

    Abstract: Disclosed herein are genetically modified plants expressing multiple animal milk proteins. Further disclosed are vectors for expressing in a plant and parts thereof, multiple mammalian milk proteins; genetically modified and or gene-edited plants having at least one cell expressing and producing at least two recombinant mammalian milk proteins wherein expression may be in a seed, bean, grain, fruit, nut, legume, leaf, stem, root, or portion thereof, the recombinant protein being produced by the plant cell; and a method of producing a food, medicament, cosmetic or blocking composition from the genetically modified or gene-edited plant. Reduction or elimination of seed storage proteins in a cell or cells wherein the milk proteins are expressed, or reduction of plant enzymes that can increase the content of oleic and/or stearic fatty acids and/or reduce the content of saturated fats in the plants or plant products are also disclosed.

    CELLULOSE-SYNTHASE-LIKE ENZYMES AND USES THEREOF
    4.
    发明申请
    CELLULOSE-SYNTHASE-LIKE ENZYMES AND USES THEREOF 有权

    公开(公告)号：US20220217934A1

    公开(公告)日：2022-07-14

    申请号：US17272685

    申请日：2019-09-05

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Maxim ITKIN ,  Adam JOZWlAK

    IPC: A01H6/82 ,  C12N15/82 ,  C12N9/10

    Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

    BIOCONTROL ENHANCERS
    5.
    发明申请
    BIOCONTROL ENHANCERS 审中-公开

    公开(公告)号：US20200367493A1

    公开(公告)日：2020-11-26

    申请号：US16323787

    申请日：2017-06-06

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Ilana KOLODKIN-GAL ,  Asaph AHARONI

    IPC: A01N43/16 ,  A01N43/12

    Abstract: The present invention relates to the identification and use of natural plant compounds for inducing, enhancing and maintaining beneficial rhizobacteria biofilm formation on a plant or plant part thereof, and conversely, inhibiting formation of biofilms and pellicle by plant pathogens. Methods of use for stimulating matrix production from the beneficial rhizobacteria and enhanced adhesion of the rhizobacteria to a plant or plant part thereof are also described. Methods of use for inhibition plant pathogen adhesion to biofilms are also described.

    PLANT WITH ALTERED CONTENT OF STEROIDAL ALKALOIDS
    7.
    发明申请
    PLANT WITH ALTERED CONTENT OF STEROIDAL ALKALOIDS 有权

    公开(公告)号：US20220408679A1

    公开(公告)日：2022-12-29

    申请号：US17859053

    申请日：2022-07-07

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Maxim ITKIN

    IPC: A01H6/82 ,  C12N15/82 ,  C12N9/10

    Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.

    PLANT WITH ALTERED CONTENT OF STEROIDAL GLYCOALKALOIDS
    8.
    发明申请
    PLANT WITH ALTERED CONTENT OF STEROIDAL GLYCOALKALOIDS 审中-公开
    植物具有改变的外源性甘草酸的含量

    公开(公告)号：US20160122775A1

    公开(公告)日：2016-05-05

    申请号：US14895059

    申请日：2014-06-02

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph AHARONI ,  Maxim ITKIN

    IPC: C12N15/82

    CPC classification number: C12N15/8218 ,  C12N15/8243 ,  C12N15/8247

    Abstract: The present invention relates to genetically modified plants by key genes involved in the biosynthesis of steroidal alkaloids. These plants have altered content of steroidal (glyco)alkaloids. Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids are provided.

    Abstract translation: 本发明涉及通过涉及甾体生物碱生物合成的关键基因的遗传修饰植物。 这些植物改变了类固醇（glyco）生物碱的含量。 提供了抗营养型甾体生物碱含量降低的茄科作物。

    GLYCOALKALOID METABOLISM ENYZYMES (GAMES) AND USES THEREOF
    9.
    发明申请
    GLYCOALKALOID METABOLISM ENYZYMES (GAMES) AND USES THEREOF 有权

    公开(公告)号：US20250092415A1

    公开(公告)日：2025-03-20

    申请号：US18910862

    申请日：2024-10-09

    Applicant: Yeda Research and Development Co. Ltd. ,  Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.

    Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Pablo D. CARDENAS ,  Saul BURDMAN

    IPC: C12N15/82 ,  C12N9/02 ,  C12N9/04

    Abstract: Disclosed herein are genetically modified plants having altered biological activity of 3-β-hydroxysteroid dehydrogenase/isomerase (GAME25), or 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plants have an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Further disclosed herein are genetically modified plants having altered expression of a gene encoding a 3-β-hydroxysteroid dehydrogenase/isomerase (GAME25), or a 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plant has an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Methods of producing these genetically modified plants are also disclosed.

    CELLULOSE-SYNTHASE-LIKE ENZYMES AND USES THEREOF
    10.
    发明公开
    CELLULOSE-SYNTHASE-LIKE ENZYMES AND USES THEREOF 审中-公开

    公开(公告)号：US20240315192A1

    公开(公告)日：2024-09-26

    申请号：US18735258

    申请日：2024-06-06

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

    Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Maxim ITKIN ,  Adam JOZWIAK

    IPC: A01H6/82 ,  C12N9/10 ,  C12N15/82

    CPC classification number: A01H6/82 ,  C12N9/1059 ,  C12N15/8218 ,  C12N15/8243 ,  C12N15/8247

    Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

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