公开(公告)号：US07490436B2

公开(公告)日：2009-02-17

申请号：US09837020

申请日：2001-04-18

申请人： Yasushi Kohno ,  Noritoshi Katsutani

发明人： Yasushi Kohno ,  Noritoshi Katsutani

IPC分类号： A01C1/06

CPC分类号： A01C1/06 ,  Y10S47/09 ,  Y10S47/11

摘要： A method of preventing defective germination or growth of a plant is provided, by which even plant seeds having small size can be sown easily and securely. The method of preventing defective germination or growth of a plant includes the steps of: encapsulating plant seeds in an aqueous gel capsule; refrigerating the plant seeds under the condition that the plant seeds do not germinate; and sowing the plant seeds.

公开(公告)号：US08695409B2

公开(公告)日：2014-04-15

申请号：US13596385

申请日：2012-08-28

申请人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

发明人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

IPC分类号： G01M15/04

CPC分类号： G01F1/6842 ,  G01F1/698 ,  G01F1/6983 ,  G01F5/00

摘要： An air flow rate measuring apparatus includes a heater and a control circuit. The heater heats a part of an intake air sucked into an engine. The control circuit controls an energization of the heater. The heater has a measuring-mode temperature when a flow rate of the intake air is measured. The control circuit has a heat cleaner which temporarily raises a temperature of the heater higher than the measuring-mode temperature when an energization of the air flow rate measuring apparatus is started.

摘要翻译： 空气流量测量装置包括加热器和控制电路。 加热器加热吸入发动机的进气的一部分。 控制电路控制加热器的通电。 当测量进气的流量时，加热器具有测量模式温度。 控制电路具有在开始空气流量测量装置通电时临时使加热器的温度高于测量模式温度的热清洁器。

公开(公告)号：US20130317065A1

公开(公告)日：2013-11-28

申请号：US13980604

申请日：2012-01-24

申请人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

发明人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

IPC分类号： A61K31/4439 ,  C07D401/14 ,  C07D413/14 ,  C07D405/06 ,  C07D417/06 ,  A61K31/506 ,  A61K31/444 ,  A61K31/427 ,  A61K31/41 ,  A61K31/4245 ,  C07D401/06 ,  C07D405/14 ,  C07D409/14 ,  A61K31/404

CPC分类号： A61K31/4245 ,  A61K31/404 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D209/18 ,  C07D401/06 ,  C07D401/14 ,  C07D403/10 ,  C07D405/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D419/14 ,  A61K2300/00

摘要： The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

摘要翻译： 本发明提供了具有EP1受体拮抗作用的本发明通式（I）表示的化合物：其中A表示苯环，吡啶环等; Y1表示C1-6亚烷基等; Y2表示单键等; Z表示-C（= O）-NHSO 2 R 6，酸性5元杂环基等; R1表示氢原子等; R 2表示苯基，5元芳族杂环基等; R3表示卤素原子，C1-6烷氧基等; R 4表示氢原子，卤素原子等; R5表示氢原子等; R6表示C1-6烷基等〕或其药学上可接受的盐。 此外，本发明的化合物（I）可以用作治疗或预防LUTS，特别是OAB的各种症状的药剂。

公开(公告)号：US20100160335A1

公开(公告)日：2010-06-24

申请号：US12452172

申请日：2008-06-18

申请人： Yasushi Kohno ,  Koji Ochiai ,  Satoshi Takita ,  Akihiko Kojima ,  Tomohiko Eiraku ,  Tetsuya Kishi

发明人： Yasushi Kohno ,  Koji Ochiai ,  Satoshi Takita ,  Akihiko Kojima ,  Tomohiko Eiraku ,  Tetsuya Kishi

IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D403/00

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

摘要： It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.

摘要翻译： 提供由以下通式（1）表示的新的哒嗪酮衍生物，其可用作药物并具有磷酸二酯酶抑制作用：其中R1表示H或C1-6烷基，R2和R3各自表示H，X C 1-6烷氧基，Z表示O或S，A表示AA或BB，其中AA表示：BB表示：其中R4表示H或C1-6烷基，R5和R6各自表示C1-6烷基。

公开(公告)号：US07703320B2

公开(公告)日：2010-04-27

申请号：US12120517

申请日：2008-05-14

申请人： Junzo Yamaguchi ,  Yasushi Kohno

发明人： Junzo Yamaguchi ,  Yasushi Kohno

IPC分类号： G01F1/68

CPC分类号： G01F1/692

摘要： According to a flow measuring device, first ranges formed by a first plurality of resistors form a single continuous value range on a flow direction coordinate axis. Thus, the first plurality of resistors is limited from being thermally insulated from one another in the flow direction, and thereby detectivity is improved. Also, second ranges formed by a second plurality of resistors form an other single continuous value range on a longitudinal direction coordinate axis. The other continuous value range includes a position that corresponds to a half length of a heating element in a longitudinal direction. As a result, detection difference is obtained at the position, at which a temperature is most optimally detected, and thereby detectivity is further improved.

摘要翻译： 根据流量测量装置，由第一多个电阻器形成的第一范围在流动方向坐标轴上形成单个连续值范围。 因此，第一多个电阻器被限制为在流动方向上彼此热绝缘，从而提高了检测性。 此外，由第二多个电阻器形成的第二范围在纵向坐标轴上形成另一个单个连续值范围。 另一连续值范围包括对应于加热元件在纵向上的半长度的位置。 结果，在最佳检测温度的位置处获得检测差异，从而进一步提高检测性。

公开(公告)号：US20080275008A1

公开(公告)日：2008-11-06

申请号：US12213187

申请日：2008-06-16

申请人： Yasushi Kohno ,  Kiyoaki Tanaka ,  Kazuhiko Kuriyama ,  Wataru Hori

发明人： Yasushi Kohno ,  Kiyoaki Tanaka ,  Kazuhiko Kuriyama ,  Wataru Hori

IPC分类号： A61K31/662

CPC分类号： C07C47/575 ,  C07C45/71 ,  C07F7/1804 ,  C07F9/3826 ,  C07F9/3882 ,  C07F9/4015 ,  C07F9/4056 ,  C07F9/653

摘要： Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

摘要翻译： 氨基膦酸衍生物（例如2-氨基-5- [4-（3-苄氧基苯硫基）-2-氯苯基] -2-甲基戊基膦酸酯单酯）由以下通式（1）表示：作为有效的S1P受体调节剂， 减少副作用。

公开(公告)号：US06694811B2

公开(公告)日：2004-02-24

申请号：US10379938

申请日：2003-03-06

申请人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

发明人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

IPC分类号： G01F168

CPC分类号： G01F1/6842

摘要： A flow meter is formed with a passage for introducing and carrying air to measure and has a sensing part disposed in the passage for measuring a flow rate of the air. A contraction part is formed on an inner surface of the passage so that the contraction part faces the sensing part. The contraction part narrows the flow of the air flowing near the sensing part. A flat surface of the contraction part is formed in parallel with the surface of the sensing part and at least upstream of the sensing part. Thus, collision of particles against the sensing part and adhesion of contaminants to the sensing pert are inhibited. Meanwhile, the flow rate of the air is measured stably and accurately.

摘要翻译： 流量计形成有用于引入和携带空气进行测量的通道，并且具有设置在通道中的用于测量空气流量的感测部分。 收缩部分形成在通道的内表面上，使得收缩部分面向感测部分。 收缩部分使感应部分附近的空气流动变窄。 收缩部分的平坦表面形成为与感测部分的表面平行并且至少在感测部分的上游。 因此，抑制了颗粒与传感部分的碰撞以及污染物与传感污染物的粘附。 同时，稳定且准确地测量空气的流量。

公开(公告)号：US5902398A

公开(公告)日：1999-05-11

申请号：US724689

申请日：1996-10-01

申请人： Yasushi Kohno ,  Takeo Hayashi

发明人： Yasushi Kohno ,  Takeo Hayashi

IPC分类号： A01C1/00 ,  A01C1/06 ,  A01H4/00 ,  B05C1/02 ,  B05C11/00 ,  C12M3/00 ,  C12N11/04

CPC分类号： A01H4/006 ,  A01C1/06

摘要： An artificial seed manufacturing apparatus in which enclosures can be inserted into capsules without fail, and the diameter of the capsule can automatically be controlled. This apparatus comprises: an enclosure supply mechanism with a container, a tip, and a driving source; a coating material delivery mechanism with a passage, a pressure plunger, a hollow nozzle plunger, and a stepping motor; and a control unit for controlling the enclosure supply mechanism and the coating material delivery mechanism, comprising: moving distance storing means for erasably storing setting data which are inputted through setting operation to designate moving distance of the pressure plunger; and stepping motor control means for supplying driving pulse, the stepping motor control means allowing the pressure plunger to reciprocate by the moving distance, to the stepping motor based on the data stored in the moving distance storing means.

摘要翻译： 一种人造种子制造装置，其中外壳可以不经故障地插入胶囊中，并且可以自动控制胶囊的直径。 该装置包括：具有容器，尖端和驱动源的机壳供给机构; 具有通道的涂料输送机构，压力柱塞，中空喷嘴柱塞和步进电机; 以及控制单元，用于控制所述外壳供应机构和所述涂料输送机构，包括：移动距离存储装置，用于可移除存储装置，用于通过设定操作输入的设定数据，以指定所述压力柱塞的移动距离; 以及用于提供驱动脉冲的步进电机控制装置，使得压力柱塞能够通过移动距离往复运动的步进电机控制装置基于存储在移动距离存储装置中的数据到步进电机。

公开(公告)号：US5866193A

公开(公告)日：1999-02-02

申请号：US977753

申请日：1997-11-25

申请人： Yasushi Kohno ,  Takamichi Maejima ,  Kazushi Nakatsukasa

发明人： Yasushi Kohno ,  Takamichi Maejima ,  Kazushi Nakatsukasa

IPC分类号： A01C1/06 ,  A01N3/00

CPC分类号： A01C1/06

摘要： An apparatus for encapsulating seed by gel comprising a seed supplying portion and a processing portion, wherein seed has fallen from a hopper of a seed supplying portion are carried to a plurality of processing nozzles of a processing portion, for encapsulating seed by gelling. A supplying portion comprising the hopper filled with seed, a carrying device disposed below the hopper for arranging seed in correspondence with the number of processing nozzle of the processing portion, and switching devices disposed respectively at the end portions of seed carriage lanes formed by the carrying device so many as the processing nozzles. The carrying device comprising a box-shaped trough, partitions disposed at the upstream portion of the trough for restriction of the height of the flowing of seed, partitions for dividing the flowing of seed into streams so many as the processing nozzles, and a vibrator disposed below the trough.

摘要翻译： 一种用于通过凝胶包封种子的装置，其包括种子供应部分和处理部分，其中种子从种子供应部分的料斗中掉落到处理部分的多个处理喷嘴中，用于通过胶凝封装种子。 供给部，其包括填充有种子的料斗，设置在料斗下方的用于与处理部的处理喷嘴的数量对应地配置种子的搬运装置，以及分别设置在由搬运装置形成的种子架通道的端部的开关装置 装置如加工喷嘴那么多。 承载装置包括一个盒形槽，设置在槽的上游部分处的分隔物，用于限制种子流动的高度，用于将种子的流动分成多个流入处理喷嘴的流的分隔壁，以及设置的振动器 低于槽。

公开(公告)号：US5830271A

公开(公告)日：1998-11-03

申请号：US757600

申请日：1996-11-29

申请人： Yasushi Kohno ,  Yoichi Ido ,  Kazushi Nakatsukasa

发明人： Yasushi Kohno ,  Yoichi Ido ,  Kazushi Nakatsukasa

IPC分类号： A01C1/06 ,  B05C3/00

CPC分类号： A01C1/06

摘要： For feeding seeds contained in a tank main body of a seeds feeding section to a gel coating section by means of suction tips arranged in a seeds transfer section in order to coat them with a gellant, a total of eight through bores are formed along the upper end of the peripheral wall of the tank main body at positions corresponding to the suction tip and arranged at regular intervals so that an annular adaptor having a through bore running through the center thereof is fitted into each of the through bores. The inner peripheral wall of the through bore has a large diameter section located on the outer peripheral side of the peripheral wall for receiving a suction tip and a small diameter section smaller than the large diameter section located on the inner peripheral side of the peripheral wall for allowing seeds to pass therethrough from the tank main body. In a seeds feeding tank of a gel coating apparatus for coating seeds with a gellant and hardening the gellant to produce gel-coated seeds, seeds to be processed can be surely and securely sucked and held by suction tips before they are moved to a downstream processing step of coating seeds with a gellant regardless of the amount of seeds remaining in the seed hopper containing them.

摘要翻译： 为了将种子供给部的罐主体中所含的种子通过布置在种子转移部分中的吸引头送入凝胶涂敷部分，以便用胶凝剂涂覆它们，沿上部形成总计8个通孔 罐主体的周壁的端部在与吸嘴相对应的位置处以规则间隔布置，使得具有穿过其中心的通孔的环形适配器装配到每个通孔中。 通孔的内周壁具有位于周壁的外周侧的大直径部分，用于接收吸入尖端和小于位于周壁的内周侧的大直径部分的小直径部分， 允许种子从罐主体通过。 在用胶凝剂涂覆种子的凝胶涂布装置的种子喂养罐中，硬化胶凝剂以产生凝胶涂覆的种子，待加工的种子在被移动到下游处理之前可以被可靠和可靠地吸入并保持 使用胶凝剂涂覆种子的步骤，而不管留在装有它们的种子料斗中剩余的种子数量。