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公开(公告)号：US20150265210A1
公开(公告)日：2015-09-24
申请号：US14726629
申请日：2015-06-01
Applicant: Yeda Research and Development Co. Ltd.
Inventor： David ISRAELI , Yael Mardor , Talila Volk
CPC classification number: A61B5/4848 , A61B5/0042 , A61B5/055 , A61B5/4064 , A61B5/4836 , A61B5/743 , A61B2576/026 , A61K49/0004 , A61N2/006 , G01R33/5601 , G01R33/56366
Abstract: A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.
Abstract translation: 公开了分析对象的血脑屏障的方法。 向对象施用可检测剂量的MRI造影剂，并且在预定时间段内获取对象脑部的多个磁共振图像。 首先对两个或更多个磁共振图像进行比较，以确定脑中造影剂浓度的变化，并根据变化来评估血脑屏障功能。
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公开(公告)号：US20170100037A1
公开(公告)日：2017-04-13
申请号：US15308123
申请日：2015-04-30
Applicant: Yeda Research and Development Co. Ltd. , Ministry of Health on behalf of The Jerusalem Mental Health Center
Inventor： Alon HARMELIN , David ISRAELI , Yuri KUZNETSOV , Vyacheslav KALCHENKO
CPC classification number: A61B5/0035 , A61B5/0042 , A61B5/0071 , A61B5/0082 , A61B5/02007 , A61B5/024 , A61B5/0261 , A61B5/4064 , A61B2576/026 , G01N21/4795 , G01N21/6456 , G01N2201/06113 , G01N2201/068
Abstract: A method of transcranial brain optical imaging including obtaining a Laser Speckle (LS) image of cranial blood vessels of a subject, obtaining a Dynamic Fluorescence (DF) image of the cranial blood vessels of the subject, and combining the LS image and the DF image producing a combined color image which displays both structure of the cranial blood vessels and perfusion of blood along the cranial blood vessels. Related apparatus and methods are also described.
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