公开(公告)号：US20020058798A1

公开(公告)日：2002-05-16

申请号：US09933814

申请日：2001-08-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark Boldin ,  Eugene Varfolomeev ,  Igor Mett

IPC: C12Q001/68 ,  C07H021/04 ,  A61K048/00

CPC classification number: C07K14/70578 ,  A61K38/00 ,  C07K14/715 ,  C07K16/2866 ,  C07K2319/00 ,  C12N9/641 ,  C12N9/6475

Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.

Abstract translation: 提供了能够调节FAS / APO1功能的蛋白质。 可以通过在合适的条件下培养用含有编码这种蛋白质的DNA的载体转化的宿主细胞并分离蛋白质来制备蛋白质。

公开(公告)号：US20040013646A1

公开(公告)日：2004-01-22

申请号：US10349977

申请日：2003-01-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark Boldin ,  Igor Mett ,  Eugene Varfolomeev

IPC: A61K048/00 ,  A61K039/395 ,  C07K016/30 ,  C07H021/04

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K14/7151 ,  C07K16/2878 ,  C07K2317/82 ,  C07K2319/00

Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.

Abstract translation: 本发明通常涉及能够调节p55和p75 TNF-R和FAS-R功能的p55和p75 TNF-R和FAS-R的细胞内结构域的新型蛋白质，以及 编码它们的DNA序列。 本发明还涉及具有TNF-R和FAS-R的混合物的新的可溶性寡聚TNF-R，寡聚FAS-Rs和寡聚受体。 此外，本发明涉及上述所有方法的制备和用途。