公开(公告)号：US20190203270A1

公开(公告)日：2019-07-04

申请号：US16319499

申请日：2016-07-24

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Ido AMIT ,  David LARA-ASTIASO ,  Meital GURY

IPC: C12Q1/6811 ,  C12Q1/6818 ,  C12Q1/6876

CPC classification number: C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6818 ,  C12Q1/6876 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/6875 ,  C12Q2522/101 ,  C12Q2563/185

Abstract: Methods of analyzing DNA molecules in a cell sample are provided. The DNA molecules have DNA binding moiety signatures which are defined by at least two non-identical DNA binding moieties. Kits for analyzing the DNA are also provided.

公开(公告)号：US20170037453A1

公开(公告)日：2017-02-09

申请号：US15303741

申请日：2015-04-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  David LARA - ASTIASO ,  Meital GURY

IPC: C12Q1/68 ,  G01N33/53

Abstract: A method of analyzing DNA which, in a cell, is bound to a DNA binding moiety, the method comprising: (a) obtaining at least two samples of complexes of DNA bound to a DNA binding moiety; (b) isolating the complexes on a solid support; (c) labeling the DNA of the complexes, wherein the labeling distinguishes between the complexes of the first of the at least two samples and the complexes of the second of the at least two samples; (d) pooling the at least two samples of complexes; and (e) isolating the complexes using an agent which specifically binds to the DNA binding moiety; and (f) analyzing the DNA of the complexes.

Abstract translation: 一种分析在细胞中与DNA结合部分结合的DNA的方法，所述方法包括：（a）获得至少两个与DNA结合部分结合的DNA的复合物样品; （b）在固体支持物上分离复合物; （c）标记复合物的DNA，其中所述标记区分所述至少两个样品中的第一个样品的复合物和所述至少两个样品中的第二个样品的复合物; （d）汇集至少两个复合物样品; 和（e）使用特异性结合DNA结合部分的试剂分离复合物; 和（f）分析复合物的DNA。