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1.发明授权Amino acid imide derivatives, usage thereof, and medicinal composition containing the same 失效氨基酰亚胺衍生物，其用途和含有它们的药物组合物
公开(公告)号：US4916146A
公开(公告)日：1990-04-10
申请号：US288556
申请日：1988-12-22
申请人： Yoshiaki Tanaka , Tomoji Aotsuka , Naomi Kobayashi , Naoki Nakata , Kuniyoshi Ogura , Motoki Torizuka , Naoyoshi Miura , Heihachiro Arai
发明人： Yoshiaki Tanaka , Tomoji Aotsuka , Naomi Kobayashi , Naoki Nakata , Kuniyoshi Ogura , Motoki Torizuka , Naoyoshi Miura , Heihachiro Arai
IPC分类号： C12N9/99 , A61K31/425 , A61K31/426 , A61P25/28 , A61P43/00 , C07D207/00 , C07D277/06 , C07D413/06 , C07D417/06
CPC分类号： C07D417/06 , C07D277/06
摘要： Novel N-substituted amino acid imide derivatives are disclosed. The compounds are represented by formula (I): ##STR1## wherein n represents an integer of 0 to 5, and X and Y, which may be the same or different, represent a methylene group or a sulfur atom, provided that not both X and Y are methylene groups at the same time. The compounds are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.
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公开(公告)号：US5028604A
公开(公告)日：1991-07-02
申请号：US444702
申请日：1989-12-01
申请人： Motoki Torizuka , Tomoji Aotsuka , Mitsuo Soeda , Kuniyoshi Ogura , Yoshiaki Tanaka , Hisayoshi Kato , Naoki Nakata , Naoyoshi Miura , Hikari Morita
发明人： Motoki Torizuka , Tomoji Aotsuka , Mitsuo Soeda , Kuniyoshi Ogura , Yoshiaki Tanaka , Hisayoshi Kato , Naoki Nakata , Naoyoshi Miura , Hikari Morita
IPC分类号： C07D207/16 , C07D211/60 , C07D277/06 , C07D279/12 , C07D417/06 , C07K5/078
CPC分类号： C07D417/06 , C07D207/16 , C07D211/60 , C07D277/06 , C07D279/12 , C07K5/06165
摘要： Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.
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公开(公告)号：US5407950A
公开(公告)日：1995-04-18
申请号：US952499
申请日：1992-12-07
申请人： Akihiro Okubo , Hiroyasu Nishioka , Heihachiro Arai , Yoshiaki Tanaka , Hisayoshi Kato , Naoki Nakata
发明人： Akihiro Okubo , Hiroyasu Nishioka , Heihachiro Arai , Yoshiaki Tanaka , Hisayoshi Kato , Naoki Nakata
IPC分类号： C07D207/16 , C07D277/06 , C07D405/14 , C07D417/06 , C07D417/14 , C07D407/06 , A61K31/40 , A61K31/425 , C07D403/06
CPC分类号： C07D405/14 , C07D207/16 , C07D277/06 , C07D417/06 , C07D417/14
摘要： Arylalkanoylamine derivatives having excellent prolyl endopeptidase inhibitory action and resistances to hypoxia and amnesia which are represented by the following general formula (I): ##STR1## wherein A represents an indanyl, indenyl, 1,2,3,4-tetrahydronaphthalenyl or benzofuranyl group; m represents an integer of 0 to 5; Z represents a hydroxymethyl, formyl, nitrile, hydroxyiminomethyl, semicarbazonomethyl or dialkoxymethyl group; X and Y may be the same or different, and individually represent a methylene group or sulfur atom, wherein compounds defined by the following substituents are excluded: A represents an indanyl, indenyl, or 1,2,3,4-tetrahydronaphthalenyl group; X and Y each represent a methylene group; and Z represents a hydroxymethyl or formyl group. Also disclosed is a pharmaceutical composition and method for improving mneme, cerebral circulation and cerebral metabolism comprising the arylalkanoylamine derivatives as the effective ingredient.
摘要翻译： PCT No.PCT / JP91 / 00771 Sec。 371日期：1992年12月7日 102（e）日期1992年12月7日PCT提交1991年6月7日PCT公布。 第WO91 / 18877号公报 1991年12月12日。具有优异的脯氨酰内肽酶抑制作用和由以下通式（I）表示的缺氧和遗忘抗性的芳基烷酰胺衍生物：2,3,4-四氢萘基或苯并呋喃基; m表示0〜5的整数， Z表示羟甲基，甲酰基，腈，羟基亚氨基甲基，氨基丙基甲基或二烷氧基甲基; X和Y可以相同或不同，并且各自表示亚甲基或硫原子，其中排除由以下取代基定义的化合物：A表示茚满基，茚基或1,2,3,4-四氢萘基; X和Y各自表示亚甲基; Z表示羟甲基或甲酰基。 还公开了包含芳基烷酰胺衍生物作为有效成分的用于改善大脑，脑循环和脑代谢的药物组合物和方法。
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公开(公告)号：US6017929A
公开(公告)日：2000-01-25
申请号：US687446
申请日：1996-08-15
IPC分类号： C07D277/06 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/54 , A61P25/00 , A61P25/28 , A61P43/00 , C07D207/08 , C07D207/16 , C07D211/60 , C07D263/06 , C07D279/12 , C07D401/06 , C07D417/06 , A01N43/40
CPC分类号： A61K31/445 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/54
摘要： The invention relates to a cholinesterase activator comprising, as an active ingredient, a compound represented by the following general formula (I): ##STR1## wherein A means a group such as a phenyl group or indanyl group, B denotes a group such as a prolyl group or thioprolyl group, and m stands for an integer of 0-5.The cholinesterase activator according to the invention has a strongly activating action on cholinesterase, in particular, a selectively activating action on peripheral cholinesterase and is also high in safety. It is hence useful as an agent for preventing and treating the side effects of central cholinesterase inhibitors, in particular, hepatopathy, and an agent for preventing and treating the side effects of various medicines manifested on the basis of a cholinesterase-inhibiting action.
摘要翻译： PCT No.PCT / JP95 / 00229 Sec。 371日期：1996年8月15日 102（e）日期1996年8月15日PCT提交1995年2月17日PCT公布。 WO95 / 22326 PCT公开号 日期：1995年8月24日本发明涉及一种胆碱酯酶活化剂，其包含作为活性成分的由以下通式（I）表示的化合物：其中A表示苯基或茚满基的基团，B表示下述通式 作为脯氨酰基或硫代丙氨基，m代表0-5的整数。 根据本发明的胆碱酯酶活化剂对胆碱酯酶具有强烈的活化作用，特别是对周围胆碱酯酶的选择性活化作用，并且安全性也高。 因此，作为预防和治疗中枢胆碱酯酶抑制剂，特别是肝病的副作用的药剂和用于预防和治疗基于胆碱酯酶抑制作用而表现的各种药物的副作用的药剂是有用的。
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公开(公告)号：US08404062B2
公开(公告)日：2013-03-26
申请号：US12449672
申请日：2008-01-15
申请人： Satoshi Ueoka , Naoki Nakata , Takashi Kuroki , Nobuo Nishiura
发明人： Satoshi Ueoka , Naoki Nakata , Takashi Kuroki , Nobuo Nishiura
CPC分类号： C21D1/667 , B21B45/0218 , B21B45/0233 , C21D9/46 , F27D15/0206
摘要： A cooling device and a cooling method for a hot strip allow uniform and stable cooling of the strip at a high cooling rate when supplying the coolant to the upper surface of the hot strip. The cooling device includes an upper header unit 21 for supplying a rod-like flow to the upper surface of the strip 10. The upper header unit 21 is formed of the first upper header group including plural first upper headers 21a arranged in a conveying direction and a second upper header group including plural second upper headers 21b arranged in the conveying direction. The cooling device is provided with an ON-OFF mechanism 30 to allow each of the upper headers 21a and 21b of the first and the second upper header groups to independently execute the ON-OFF control (start/end injection control) of an injection (feeding) of the rod-like flow.
摘要翻译： 当将冷却剂供应到热带的上表面时，用于热带的冷却装置和冷却方法允许以高冷却速率均匀且稳定地冷却条带。 冷却装置包括用于向条10的上表面供应棒状流的上集管单元21.上集管单元21由包括沿输送方向布置的多个第一上集管21a的第一上集管组构成， 包括沿传送方向布置的多个第二上集管21b的第二上集管组。 冷却装置设置有开 - 关机构30，以允许第一和第二上集管组的上集管21a和21b中的每一个独立地执行喷射的开 - 关控制（开始/结束喷射控制） 进给）棒状流。
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公开(公告)号：US08506879B2
公开(公告)日：2013-08-13
申请号：US13565114
申请日：2012-08-02
申请人： Satoshi Ueoka , Akio Fujibayashi , Naoki Nakata , Takashi Kuroki , Shougo Tomita
发明人： Satoshi Ueoka , Akio Fujibayashi , Naoki Nakata , Takashi Kuroki , Shougo Tomita
CPC分类号： B21B45/0218 , B21B45/0233
摘要： A method for cooling a hot strip conveyed on a run-out table after finishing, including ejecting rod-like flows of cooling water from nozzles to the upper surface of the steel strip such that the flows are inclined toward a traveling direction of the steel strip, and draining the cooling water using draining means disposed downstream of the nozzles.
摘要翻译： 一种在精加工之后冷却在走出台上传送的热带的方法，包括将喷嘴的棒状冷却水流从钢带排出到钢带的上表面，使得流向钢带的行进方向倾斜 并且使用布置在喷嘴下游的排水装置排出冷却水。
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公开(公告)号：US20100024505A1
公开(公告)日：2010-02-04
申请号：US12449672
申请日：2008-01-15
申请人： Satoshi Ueoka , Naoki Nakata , Takashi Kuroki , Nobuo Nishiura
发明人： Satoshi Ueoka , Naoki Nakata , Takashi Kuroki , Nobuo Nishiura
CPC分类号： C21D1/667 , B21B45/0218 , B21B45/0233 , C21D9/46 , F27D15/0206
摘要： A cooling device and a cooling method for a hot strip allow uniform and stable cooling of the strip at a high cooling rate when supplying the coolant to the upper surface of the hot strip. The cooling device includes an upper header unit 21 for supplying a rod-like flow to the upper surface of the strip 10. The upper header unit 21 is formed of the first upper header group including plural first upper headers 21a arranged in a conveying direction and a second upper header group including plural second upper headers 21b arranged in the conveying direction. The cooling device is provided with an ON-OFF mechanism 30 to allow each of the upper headers 21a and 21b of the first and the second upper header groups to independently execute the ON-OFF control (start/end injection control) of an injection (feeding) of the rod-like flow.
摘要翻译： 当将冷却剂供应到热带的上表面时，用于热带的冷却装置和冷却方法允许以高冷却速率均匀且稳定地冷却条带。 冷却装置包括用于向条10的上表面供应棒状流的上集管单元21.上集管单元21由包括沿输送方向布置的多个第一上集管21a的第一上集管组构成， 包括沿传送方向布置的多个第二上集管21b的第二上集管组。 冷却装置设置有开 - 关机构30，以允许第一和第二上集管组的上集管21a和21b中的每一个独立地执行喷射的开 - 关控制（开始/结束喷射控制） 进给）棒状流。
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公开(公告)号：US08444909B2
公开(公告)日：2013-05-21
申请号：US13471552
申请日：2012-05-15
申请人： Satoshi Ueoka , Akio Fujibayashi , Naoki Nakata , Takashi Kuroki , Shougo Tomita
发明人： Satoshi Ueoka , Akio Fujibayashi , Naoki Nakata , Takashi Kuroki , Shougo Tomita
CPC分类号： B21B45/0218 , B21B45/0233 , B21B45/0281
摘要： A hot-strip cooling device for cooling a hot strip that has been subjected to finish rolling while being conveyed over a run-out table. The device includes a plurality of cooling nozzles that are disposed above a steel strip and eject rod-like flows of coolant at an ejection angle tilted toward the upstream side in a steel-strip traveling direction; and purging means that is disposed on the upstream side with respect to the cooling nozzles and purges the coolant that has been ejected from the cooling nozzles and resides on the steel strip.
摘要翻译： 一种热带冷却装置，用于冷却经过精轧的热轧钢带，同时在排出台上运送。 该装置包括：多个冷却喷嘴，其设置在钢带上方，并且以钢带移动方向朝向上游侧倾斜的喷射角度排出棒状的冷却剂流; 并且清洗装置相对于冷却喷嘴设置在上游侧，并且清除已经从冷却喷嘴排出并驻留在钢带上的冷却剂。
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公开(公告)号：US08231826B2
公开(公告)日：2012-07-31
申请号：US12224195
申请日：2006-11-09
申请人： Satoshi Ueoka , Akio Fujibayashi , Naoki Nakata , Takashi Kuroki , Shougo Tomita
发明人： Satoshi Ueoka , Akio Fujibayashi , Naoki Nakata , Takashi Kuroki , Shougo Tomita
CPC分类号： B21B45/0218 , B21B45/0233 , B21B45/0281
摘要： A hot-strip cooling device and a cooling method are provided wherein uniform cooling of a hot-rolled steel strip using coolant is possible from the leading end to the trailing end of the steel strip. A cooling device (10) includes a plurality of round nozzles (15) disposed obliquely in such a manner as to eject rod-like flows of coolant at an ejection angle θ toward the upstream side in a direction in which a steel strip (12) travels, and a pinch roll (11) disposed on the upstream side with respect to the round nozzles (15) and configured to pinch the steel strip (12) in combination with a roller table (8).
摘要翻译： 提供一种热带冷却装置和冷却方法，其中使用冷却剂的热轧钢带的均匀冷却可以从钢带的前端到后端。 冷却装置（10）包括多个圆形喷嘴（15），倾斜地设置成以喷射角度喷射棒状冷却剂流; 朝向钢带（12）行进的方向的上游侧，以及相对于圆形喷嘴（15）设置在上游侧的夹送辊（11），并且构造成组合地夹紧钢带（12） 带有一个滚轮台（8）。
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公开(公告)号：US20120017660A1
公开(公告)日：2012-01-26
申请号：US13256288
申请日：2010-03-23
申请人： Takashi Kuroki , Naoki Nakata , Kenji Hirata , Takayuki Furumai , Yukio Fujii , Motoji Terasaki
发明人： Takashi Kuroki , Naoki Nakata , Kenji Hirata , Takayuki Furumai , Yukio Fujii , Motoji Terasaki
CPC分类号： B21B45/08 , B21B39/08 , B21B45/0218
摘要： A facility is provided for manufacturing a steel plate excellent in steel plate shape and mechanical property while setting low cooling-water spraying performance in a descaling step and achieving uniform cooling in a cooling step. Specifically, a hot rolling mill 3, a first hot leveler 5, a descaler 4, and cooling equipment 6 are arranged in that order from the upstream side in a conveying direction. A pressure P [MPa] at the point of impact of cooling water sprayed from the descaler to each surface of a steel plate 1 is greater than or equal to 1.5 MPa.
摘要翻译： 提供一种用于制造钢板形状和机械性能优异的钢板的设备，同时在除垢步骤中设定低冷却水喷射性能并且在冷却步骤中实现均匀的冷却。 具体而言，从输送方向的上游侧依次配置热轧机3，第一烫平机5，除垢机4和冷却装置6。 从除垢剂喷射到钢板1的各表面的冷却水的冲击点的压力P [MPa]大于或等于1.5MPa。
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