公开(公告)号：US5028604A

公开(公告)日：1991-07-02

申请号：US444702

申请日：1989-12-01

申请人： Motoki Torizuka ,  Tomoji Aotsuka ,  Mitsuo Soeda ,  Kuniyoshi Ogura ,  Yoshiaki Tanaka ,  Hisayoshi Kato ,  Naoki Nakata ,  Naoyoshi Miura ,  Hikari Morita

发明人： Motoki Torizuka ,  Tomoji Aotsuka ,  Mitsuo Soeda ,  Kuniyoshi Ogura ,  Yoshiaki Tanaka ,  Hisayoshi Kato ,  Naoki Nakata ,  Naoyoshi Miura ,  Hikari Morita

IPC分类号： C07D207/16 ,  C07D211/60 ,  C07D277/06 ,  C07D279/12 ,  C07D417/06 ,  C07K5/078

CPC分类号： C07D417/06 ,  C07D207/16 ,  C07D211/60 ,  C07D277/06 ,  C07D279/12 ,  C07K5/06165

摘要： Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

公开(公告)号：US5198450A

公开(公告)日：1993-03-30

申请号：US601795

申请日：1991-01-07

申请人： Kuniyoshi Ogura ,  Tomoji Aotsuka ,  Motoki Torizuka ,  Mitsuo Soeda ,  Yoshiaki Tanaka ,  Hisayoshi Kato ,  Naoyoshi Miura ,  Noaki Nakata ,  Hikaru Morita ,  Akihiro Okubo

发明人： Kuniyoshi Ogura ,  Tomoji Aotsuka ,  Motoki Torizuka ,  Mitsuo Soeda ,  Yoshiaki Tanaka ,  Hisayoshi Kato ,  Naoyoshi Miura ,  Noaki Nakata ,  Hikaru Morita ,  Akihiro Okubo

IPC分类号： C07D295/18 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61P25/28 ,  C07D207/20 ,  C07D211/70 ,  C07D277/04 ,  C07D295/185

CPC分类号： C07D295/185 ,  C07D207/20 ,  C07D211/70 ,  C07D277/04

摘要： An agent for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance is disclosed. The agent comprises as an effective component a phenylalkanoylamine derivative represented by the following formula (I), ##STR1## wherein A represents a 1,3-thiazolidin-3-yl group, a 1,2,3,6-tetrahydropyridin-1-yl group, a morpholino group, a thiomorpholin-4-yl group, or a 3-pyrrolin-1-yl group, R.sup.1 and R.sup.2, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, a guanidino group, or a group ##STR2## (wherein R.sup.3 and R.sup.4 independently represent a lower alkyl group or form in combination 5- or 6-membered heterocyclic group), and n represents an integer of 2-6, or a salt thereof. This agent is effective for treating or preventing cerebral hemorrhage sequela, cerebral infarction sequela, cerebral arterioscleosis, subarachnoid hemorrhage sequela, cranial injury sequela, cerebral operation sequela, cerebrovascular dementia, Parkinson's disease, Alzheimer's disease, Pick's disease, various anoxia toxicosis including, but not limited to anthracemia sequela, cerebral alcoholism related diseases, and the like.

公开(公告)号：US4916146A

公开(公告)日：1990-04-10

申请号：US288556

申请日：1988-12-22

申请人： Yoshiaki Tanaka ,  Tomoji Aotsuka ,  Naomi Kobayashi ,  Naoki Nakata ,  Kuniyoshi Ogura ,  Motoki Torizuka ,  Naoyoshi Miura ,  Heihachiro Arai

发明人： Yoshiaki Tanaka ,  Tomoji Aotsuka ,  Naomi Kobayashi ,  Naoki Nakata ,  Kuniyoshi Ogura ,  Motoki Torizuka ,  Naoyoshi Miura ,  Heihachiro Arai

IPC分类号： C12N9/99 ,  A61K31/425 ,  A61K31/426 ,  A61P25/28 ,  A61P43/00 ,  C07D207/00 ,  C07D277/06 ,  C07D413/06 ,  C07D417/06

CPC分类号： C07D417/06 ,  C07D277/06

摘要： Novel N-substituted amino acid imide derivatives are disclosed. The compounds are represented by formula (I): ##STR1## wherein n represents an integer of 0 to 5, and X and Y, which may be the same or different, represent a methylene group or a sulfur atom, provided that not both X and Y are methylene groups at the same time. The compounds are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.

公开(公告)号：US08697899B2

公开(公告)日：2014-04-15

申请号：US13822017

申请日：2011-12-26

申请人： Naoshi Murata ,  Kuniyoshi Ogura ,  Takeshi Matsuo ,  Akira Yoshioka

发明人： Naoshi Murata ,  Kuniyoshi Ogura ,  Takeshi Matsuo ,  Akira Yoshioka

IPC分类号： C07F15/00 ,  C07C67/26

CPC分类号： B01J31/12 ,  B01J31/2226 ,  B01J2531/842 ,  C07C51/412 ,  C07C67/26 ,  C07C69/54 ,  C07C57/04

摘要： There is provided a method for producing iron methacrylate being inexpensive, and being high in activity and selectivity and good in solubility to a reaction liquid when being used in production of a hydroxyalkyl methacrylate as a catalyst. The method for producing iron methacrylate for production of a hydroxyalkyl methacrylate according to the present invention includes subjecting a mixture of a metallic iron having an oxygen atom content by XRF analysis of the surface thereof of 6% by mass or lower, and methacrylic acid to a heat treatment at 95° C. or higher and lower than 110° C. for 100 to 600 min. The method for producing a hydroxyalkyl methacrylate according to the present invention includes reacting an alkylene oxide with methacrylic acid to produce the hydroxyalkyl methacrylate, wherein iron methacrylate produced by the method according to the present invention is used as a catalyst.

摘要翻译： 本发明提供了生产廉价的甲基丙烯酸铁的方法，并且当用于生产甲基丙烯酸羟烷基酯作为催化剂时，其活性和选择性高，对反应液的溶解性好。 制造本发明的甲基丙烯酸羟烷基酯的甲基丙烯酸铁的制造方法包括将表面的XRF分析得到的具有氧原子含量的金属铁的混合物的6质量％以下，甲基丙烯酸与 在95℃以上且低于110℃进行100〜600分钟的热处理。 根据本发明的制备甲基丙烯酸羟烷基酯的方法包括使环氧烷与甲基丙烯酸反应以制备甲基丙烯酸羟烷基酯，其中使用根据本发明的方法制备的甲基丙烯酸铁作为催化剂。

公开(公告)号：US5512644A

公开(公告)日：1996-04-30

申请号：US302428

申请日：1994-09-08

申请人： Kuniyoshi Ogura ,  Kouji Sasaki

发明人： Kuniyoshi Ogura ,  Kouji Sasaki

IPC分类号： A61L15/60 ,  C08F220/34 ,  C08F226/06 ,  C08F20/58 ,  C08F228/02

CPC分类号： C08F226/06 ,  A61L15/60 ,  C08F220/34

摘要： There is disclosed an ampholytic polymer capable of absorbing aqueous electrolyte solutions, which is obtainable by polymerization of a monomer mixture including (A) at least 10 mol % of an ampholytic vinyl monomer, with the proviso that when the monomer (A) has no self-crosslinkability, the amount of monomer (A) is in the range of 10 to 99.995 mol %. The monomer mixture may further include (B) 90 mol % or less of a non-ampholytic vinyl monomer and (C) 1 mol % or less of a crosslinkable monomer, with the proviso that the total amount of monomers (A), (B) and (C) is 100 mol % and when the monomer (A) has no self-crosslinkability, the amount of monomer (C) is in the range of 0.005 to 1 mol %.

摘要翻译： 公开了能够吸收水性电解质溶液的两性聚合物，其可以通过包含（A）至少10mol％的两性乙烯基单体的单体混合物的聚合而获得，条件是当单体（A）没有自身时 - 交联性，单体（A）的量在10〜99.995摩尔％的范围内。 单体混合物还可以包含（B）90mol％或更少的非两性乙烯基单体和（C）1mol％或更少的可交联单体，条件是单体（A），（B ）和（C）为100摩尔％，单体（A）不具有自交联性时，单体（C）的含量为0.005〜1摩尔％。

公开(公告)号：US5380748A

公开(公告)日：1995-01-10

申请号：US107825

申请日：1993-08-30

申请人： Yoshiaki Muto ,  Hiromi Ichikawa ,  Kuniyoshi Ogura ,  Kyoji Chaki ,  Masao Seiki ,  Toshihiko Takemasa

发明人： Yoshiaki Muto ,  Hiromi Ichikawa ,  Kuniyoshi Ogura ,  Kyoji Chaki ,  Masao Seiki ,  Toshihiko Takemasa

IPC分类号： C07C215/42 ,  C07C217/52 ,  C07C219/24 ,  C07D215/06 ,  C07D215/42 ,  C07D307/79 ,  C07D307/82 ,  C07D311/58 ,  C07D333/54 ,  C07D333/78 ,  C07D333/80 ,  C07D335/06 ,  A61K31/38 ,  A61K31/34 ,  C07D333/50 ,  C07D335/04

CPC分类号： C07D307/79 ,  C07C215/42 ,  C07C217/52 ,  C07C219/24 ,  C07D215/06 ,  C07D215/42 ,  C07D307/82 ,  C07D311/58 ,  C07D333/54 ,  C07D333/78 ,  C07D333/80 ,  C07D335/06 ,  C07C2102/08 ,  C07C2102/10 ,  C07C2102/12 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S514/928

摘要： A trialkylamine derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents lower alkyl;R.sup.3, R.sup.4 and R.sup.5 may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen;R.sup.6 and R.sup.7 may be the same or different from each other and each represents hydrogen or lower alkyl;R.sup.8 represents hydrogen, lower alkyl, lower alkoxy or halogen;X represents oxygen, sulfur, --CH.dbd.N-- or --CH.dbd.CH--;Y represents oxygen, sulfur, methylene, N--R.sup.11 (wherein R.sup.11 represents lower alkyl), SO or SO.sub.2 ;Z represents --OCO(CH.sub.2).sub.p .about. or --OCH.sub.2 (CH.sub.2).sub.p .about. (wherein p represents a number of 0 to 4 and symbol .about. represents the linkage with a benzene ring); andm and n represent each a number of 0 to 3 and the sum of m and n is 3 or less, provided that the case where m is 0, n is 1 or 2, R.sup.1 and R.sup.2 represent each methyl, X represents --CH.dbd.CH--, Y represents --CH.sub.2 --, and Z represents --O--CO.about. is excluded. These compounds have an excellent activity of ameliorating for gastrointestinal motility and hence are widely utilized in the treatment of gastrointestinal diseases.

摘要翻译： PCT No.PCT / JP92 / 00270 Sec。 371日期：1993年8月30日 102（e）日期1993年8月30日PCT 1991年3月6日PCT公布。 出版物WO92 / 15553 日本9月17日，1992.由式（1）表示的三烷基胺衍生物或其药学上可接受的盐：其中R 1和R 2可以相同或不同，各自表示低级烷基; R 3，R 4和R 5可以彼此相同或不同，并且各自表示氢，低级烷基，低级烷氧基，低级烷氧基羰基或卤素; R 6和R 7可以相同或不同，各自表示氢或低级烷基; R8代表氢，低级烷基，低级烷氧基或卤素; X表示氧，硫，-CH = N-或-CH = CH-; Y表示氧，硫，亚甲基，N-R11（其中R11表示低级烷基），SO或SO2; Z表示-OCO（CH 2）p DIFFERENCE或-OCH 2（CH 2）p差异（其中p表示0至4的数字，符号DIFFERENCE表示与苯环的连接）; m和n分别表示0〜3的数，m与n的和为3以下，m为0，n为1或2的情况下，R 1，R 2表示甲基，X表示-CH = CH-，Y表示-CH 2 - ，Z表示-O-CO不同。 这些化合物具有改善胃肠蠕动的优异活性，因此被广泛用于治疗胃肠道疾病。

公开(公告)号：US08859804B2

公开(公告)日：2014-10-14

申请号：US13148206

申请日：2010-02-04

申请人： Ryuichi Ansai ,  Hiroyuki Nogami ,  Kuniyoshi Ogura

发明人： Ryuichi Ansai ,  Hiroyuki Nogami ,  Kuniyoshi Ogura

IPC分类号： C07C67/08 ,  C07C67/54 ,  C07C69/54

CPC分类号： C07C67/08 ,  C07C67/54 ,  C07C69/54

摘要： Disclosed is a method for producing a (meth)acrylate ester wherein a high purity (meth)acrylate ester is obtained with a high yield, with a reduced loss of (meth)acrylic acid anhydride. In the method, (meth)acrylic acid is recovered with a high yield, and the (meth)acrylate ester is purified easily. Specifically disclosed is a method for producing a (meth)acrylate ester which comprises: (1) a step of producing (meth)acrylic acid anhydride by reacting a specific fatty acid anhydride and (meth)acrylic acid, while removing a by-produced fatty acid; (2) a step of obtaining a (meth)acrylate ester by reacting an alcohol and unpurified (meth)acrylic acid anhydride obtained in step (1) preferably at a temperature not less than 90° C.; and (3) a step of recovering (meth)acrylic acid by distillation preferably at a temperature not less than 90° C. The method may also comprise a step of heating or distilling the reaction liquid obtained in step (2) at a temperature not less than 90° C.

摘要翻译： 公开了一种制备（甲基）丙烯酸酯的方法，其中以（Y）丙烯酸酐的损失减少，高产率获得高纯度（甲基）丙烯酸酯。 在该方法中，以高收率回收（甲基）丙烯酸，容易地纯化（甲基）丙烯酸酯。 具体公开了一种（甲基）丙烯酸酯的制造方法，该方法包括：（1）通过使特定的脂肪酸酐和（甲基）丙烯酸反应，同时除去副产的脂肪 酸; （2）优选在不低于90℃的温度下使醇与步骤（1）中得到的未纯化的（甲基）丙烯酸酐反应得到（甲基）丙烯酸酯的步骤; 和（3）优选在不低于90℃的温度下通过蒸馏回收（甲基）丙烯酸的步骤。该方法还可以包括在步骤（2）中获得的反应液体在不是 小于90℃

公开(公告)号：US08586791B2

公开(公告)日：2013-11-19

申请号：US13057576

申请日：2009-08-04

申请人： Ryuichi Ansai ,  Hiroyuki Nogami ,  Kuniyoshi Ogura

发明人： Ryuichi Ansai ,  Hiroyuki Nogami ,  Kuniyoshi Ogura

IPC分类号： C07C65/00 ,  C07C51/56

CPC分类号： C07C51/573 ,  C07C51/56 ,  Y02P20/582 ,  C07C57/04

摘要： It is an object of the present invention to provide a method for producing (meth)acrylic anhydride that provides high yield and high efficiency and can suppress side reactions, in a method for reacting (meth)acrylic acid with a fatty acid anhydride to produce (meth)acrylic anhydride. The method for producing (meth)acrylic anhydride according to the present invention is a method for producing (meth)acrylic anhydride, including reacting a fatty acid anhydride with (meth)acrylic acid to produce (meth)acrylic anhydride, while extracting a fatty acid produced as a by-product, wherein the reaction is performed, while adjustment is performed so that a molar ratio of the (meth)acrylic acid to the (meth)acrylic anhydride in a reaction liquid is 0.3 or more.

摘要翻译： 本发明的目的是提供一种在（甲基）丙烯酸与脂肪酸酐反应生成（甲基）丙烯酸酐的方法中，提供高产率和高效率并能抑制副反应的（甲基）丙烯酸酐的制备方法， 甲基）丙烯酸酐。 本发明的（甲基）丙烯酸酐的制造方法是将（甲基）丙烯酸酐与（甲基）丙烯酸反应生成（甲基）丙烯酸酐，同时提取脂肪酸 作为副产物生产，其中进行反应，同时进行调节，使得反应液体中的（甲基）丙烯酸与（甲基）丙烯酸酐的摩尔比为0.3以上。

公开(公告)号：US20130172591A1

公开(公告)日：2013-07-04

申请号：US13822017

申请日：2011-12-26

申请人： Naoshi Murata ,  Kuniyoshi Ogura ,  Takeshi Matsuo ,  Akira Yoshioka

发明人： Naoshi Murata ,  Kuniyoshi Ogura ,  Takeshi Matsuo ,  Akira Yoshioka

IPC分类号： B01J31/12 ,  C07C67/26

CPC分类号： B01J31/12 ,  B01J31/2226 ,  B01J2531/842 ,  C07C51/412 ,  C07C67/26 ,  C07C69/54 ,  C07C57/04

摘要： There is provided a method for producing iron methacrylate being inexpensive, and being high in activity and selectivity and good in solubility to a reaction liquid when being used in production of a hydroxyalkyl methacrylate as a catalyst. The method for producing iron methacrylate for production of a hydroxyalkyl methacrylate according to the present invention includes subjecting a mixture of a metallic iron having an oxygen atom content by XRF analysis of the surface thereof of 6% by mass or lower, and methacrylic acid to a heat treatment at 95° C. or higher and lower than 110° C. for 100 to 600 min. The method for producing a hydroxyalkyl methacrylate according to the present invention includes reacting an alkylene oxide with methacrylic acid to produce the hydroxyalkyl methacrylate, wherein iron methacrylate produced by the method according to the present invention is used as a catalyst.

摘要翻译： 本发明提供了生产廉价的甲基丙烯酸铁的方法，并且当用于生产甲基丙烯酸羟烷基酯作为催化剂时，其活性和选择性高，对反应液的溶解性好。 制造本发明的甲基丙烯酸羟烷基酯的甲基丙烯酸铁的制造方法包括将表面的XRF分析得到的具有氧原子含量的金属铁的混合物的6质量％以下，甲基丙烯酸与 在95℃以上且低于110℃进行100〜600分钟的热处理。 根据本发明的制备甲基丙烯酸羟烷基酯的方法包括使环氧烷与甲基丙烯酸反应以制备甲基丙烯酸羟烷基酯，其中使用根据本发明的方法制备的甲基丙烯酸铁作为催化剂。

公开(公告)号：US20110301379A1

公开(公告)日：2011-12-08

申请号：US13148206

申请日：2010-02-04

申请人： Ryuichi Ansai ,  Hiroyuki Nogami ,  Kuniyoshi Ogura

发明人： Ryuichi Ansai ,  Hiroyuki Nogami ,  Kuniyoshi Ogura

IPC分类号： C07C67/08

CPC分类号： C07C67/08 ,  C07C67/54 ,  C07C69/54

摘要： Disclosed is a method for producing a (meth)acrylate ester wherein a high purity (meth)acrylate ester is obtained with a high yield, with a reduced loss of (meth)acrylic acid anhydride. In the method, (meth)acrylic acid is recovered with a high yield, and the (meth)acrylate ester is purified easily. Specifically disclosed is a method for producing a (meth)acrylate ester which comprises: (1) a step of producing (meth)acrylic acid anhydride by reacting a specific fatty acid anhydride and (meth)acrylic acid, while removing a by-produced fatty acid; (2) a step of obtaining a (meth)acrylate ester by reacting an alcohol and unpurified (meth)acrylic acid anhydride obtained in step (1) preferably at a temperature not less than 90° C.; and (3) a step of recovering (meth)acrylic acid by distillation preferably at a temperature not less than 90° C. The method may also comprise a step of heating or distilling the reaction liquid obtained in step (2) at a temperature not less than 90° C.

摘要翻译： 公开了一种制备（甲基）丙烯酸酯的方法，其中以（Y）丙烯酸酐的损失减少，高产率获得高纯度（甲基）丙烯酸酯。 在该方法中，以高收率回收（甲基）丙烯酸，容易地纯化（甲基）丙烯酸酯。 具体公开了一种（甲基）丙烯酸酯的制造方法，该方法包括：（1）通过使特定的脂肪酸酐和（甲基）丙烯酸反应，同时除去副产的脂肪 酸; （2）优选在不低于90℃的温度下使醇与步骤（1）中得到的未纯化的（甲基）丙烯酸酐反应得到（甲基）丙烯酸酯的步骤; 和（3）优选在不低于90℃的温度下通过蒸馏回收（甲基）丙烯酸的步骤。该方法还可以包括在步骤（2）中获得的反应液体在不是 小于90℃