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18 条记录 (耗时 0.017 秒)

    MULTI-TARGET MODULATION FOR TREATING FIBROSIS AND INFLAMMATORY CONDITIONS
    5.
    发明申请
    MULTI-TARGET MODULATION FOR TREATING FIBROSIS AND INFLAMMATORY CONDITIONS 审中-公开
    用于治疗纤维化和炎症条件的多目标调节

    公开(公告)号：US20150080320A1

    公开(公告)日：2015-03-19

    申请号：US14399909

    申请日：2013-05-14

    申请人： AADIGEN, LLC

    发明人： Neil Desai

    IPC分类号： C12N15/113 ,  A61K47/48

    CPC分类号： C12N15/1138 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/64 ,  A61K47/6455 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/3513

    摘要： The present invention relates to compositions comprising one or more active agents that selectively modulate the expression of two or more genes, for example at the post-transcription level, that are involved in fibrosis and/or inflammatory conditions. Also provided are methods of using such compositions for treating fibrotic diseases, as well as other diseases including inflammatory diseases and cancer.

    摘要翻译： 本发明涉及包含一种或多种选择性调节参与纤维化和/或炎性病症的两个或更多个基因（例如在转录后水平）的表达的活性剂的组合物。 还提供了使用这种组合物治疗纤维化疾病以及其它疾病（包括炎性疾病和癌症）的方法。

    COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
    6.
    发明公开
    COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS 审中-公开

    公开(公告)号：US20230304010A1

    公开(公告)日：2023-09-28

    申请号：US18017644

    申请日：2021-07-23

    申请人： AADIGEN, LLC

    发明人： Neil P. DESAI ,  Gilles DIVITA

    IPC分类号： C12N15/113 ,  A61P31/14

    CPC分类号： C12N15/1131 ,  A61P31/14 ,  C12N2310/14 ,  C12N2320/32

    摘要： The present application provides peptides and nucleic acids that are useful for treating virus (e.g., SARS-CoV-2) infection. Exemplary peptides comprise chimeric peptides and blocking peptides that block the interaction between SPIKE and ACE2. Exemplary nucleic acids include siRNAs that specifically target SARS-CoV-2. The present applications also provide complexes and nanoparticles further comprising a second peptide (e.g., a cell-penetrating peptide) that promotes intracellular delivery of the peptides and nucleic acids.

    PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF MOLECULES
    9.
    发明申请
    PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF MOLECULES 有权

    公开(公告)号：US20220313825A1

    公开(公告)日：2022-10-06

    申请号：US17594454

    申请日：2020-04-16

    申请人： AADIGEN, LLC

    发明人： Neil P. DESAI ,  Gilies DIVITA

    IPC分类号： A61K47/10 ,  A61K47/60 ,  A61K47/64 ,  A61K47/69 ,  A61K9/51 ,  C07K5/062

    摘要： The present application is directed to cargo delivery complexes for intracellular delivery of a cargo molecule comprising: a first peptide comprising a cell-penetrating peptide (CPP), a second peptide comprising a cell-penetrating peptide, and a cargo molecule. The second peptide comprises a polyethylene glycol (PEG) moiety linked to the second CPP, and the first peptide does not have a PEG moiety. The present application is also directed to a cargo delivery complex comprising a CPP and a cargo molecule wherein the CPP is a retro-inverso peptide. The present application is also directed to a cargo delivery complex comprising a CPP and a cargo molecule wherein the peptide further comprises a targeting sequence selected from the group consisting of GYVSK, GYVS, YIGS and YIGSR. Methods of making and using the cargo delivery complexes are also disclosed.