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公开(公告)号：US12295652B2
公开(公告)日：2025-05-13
申请号：US18307051
申请日：2023-04-26
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
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公开(公告)号：US20240382467A1
公开(公告)日：2024-11-21
申请号：US18286976
申请日：2022-04-14
Applicant: University of Virginia Patent Foundation , Old Dominion University , OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： John S. Lazo , Elizabeth R. Sharlow , John D. Catravas , Ruben ML Colunga Biancatelli , Pavel A. Solopov
IPC: A61K31/4365 , A61P31/14 , A61P39/00
Abstract: Provided are methods for treating and/or preventing diseases, disorders, and/or conditions associated with viral infections in subjects, which in some embodiments can include administering to the subject an effective amount of a PTP4A3 inhibitor. In some embodiments, the disease, disorder, and/or condition is characterized by lung damage, ALI, ARDS, or any combination thereof. Also provided are methods for reducing or inhibiting virus-induced alveolar inflammation and/or damage, methods for reducing or inhibiting induction of inflammatory cytokines and/or chemokines in subjects, methods for reducing or inhibiting pulmonary diseases, disorders, and/or conditions associated with viral infections, or pulmonary damage resulting therefrom, methods for preventing and/or treating chemical damage to lungs, uses of PTP4A3 inhibitors in the presently disclosed methods.
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公开(公告)号：US20230191114A1
公开(公告)日：2023-06-22
申请号：US17996104
申请日：2021-02-12
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Claudia MURATORI , Erin B. PURCELL , Asia POUDEL , Adenrele M. OLUDIRAN
CPC classification number: A61N1/0476 , A61N1/328 , A61N1/36034 , A61B2018/00732
Abstract: Methods and apparatuses are described herein for inactivation of bacterial biofilms using sub-microsecond pulsed electric field application to an affected surface or region. In some examples, a bacterial biofilm may be inactivated while planktonic bacteria in the vicinity of the biofilm are not inactivated. These methods and systems provide an electrical-based therapeutic modality for which bacteria in biofilms may have difficulty developing resistance, unlike antibiotic therapies.
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公开(公告)号：US11672594B2
公开(公告)日：2023-06-13
申请号：US17006406
申请日：2020-08-28
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
CPC classification number: A61B18/1492 , A61B18/1477 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00613
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
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公开(公告)号：US10982206B2
公开(公告)日：2021-04-20
申请号：US15972856
申请日：2018-05-07
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Olga Pakhomova , Andrei G. Pakhomov
Abstract: Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the method, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
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Patent Agency Ranking
公开(公告)号：US10029093B2
公开(公告)日：2018-07-24
申请号：US15151149
申请日：2016-05-10
Applicant: OLD DOMINION RESEARCH FOUNDATION
Inventor： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
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7.发明申请公开(公告)号：US20180110978A1
公开(公告)日：2018-04-26
申请号：US15559324
申请日：2016-03-18
Applicant: Old Dominion University Research Foundation
Inventor： Stephen J. BEEBE , John D. CATRAVAS
IPC: A61N1/36 , A61K31/395 , A61K45/06 , A61P35/00
CPC classification number: A61N1/36002 , A61K31/395 , A61K45/06 , A61N1/0412 , A61N1/327 , A61N1/36014 , A61P35/00
Abstract: Methods for treating tumors employing HSp90 inhibitors in combination with nanosecond pulsed electric fields (nsPEFs) are disclosed. The methods are directed to induce regulated cell death (RCD) in tumor cells and tissues. Further, Hsp90 inhibitors in combination with nsPEF are used at low non-toxic concentrations, thereby reducing the side-effects associated with these drugs. Additionally, nsPEFs are employed at lower electric fields and/or with fewer number of pulses than when nsPEFs are employed alone. Further, the mechanisms by which nsPEFs and Hsp90 inhibitors act upon cancer cells are different, thereby combining these treatments results in a synergistic effect.
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公开(公告)号：US20170165003A1
公开(公告)日：2017-06-15
申请号：US15169154
申请日：2016-05-31
Applicant: Karl H. Schoenbach , Shu Xiao
Inventor： Karl H. Schoenbach , Shu Xiao
CPC classification number: A61B18/18 , A61B18/1815 , A61N7/02
Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
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公开(公告)号：US20170095664A1
公开(公告)日：2017-04-06
申请号：US15151149
申请日：2016-05-10
Applicant: Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
Inventor： Shu Xiao , Andrei Pakhomov , Karl H. Schoenbach
CPC classification number: A61N1/36014 , A61N1/40 , A61N2/006 , A61N5/02
Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
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公开(公告)号：US09168373B2
公开(公告)日：2015-10-27
申请号：US12280280
申请日：2007-02-26
Applicant: Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Inventor： Richard Nuccitelli , Stephen J. Beebe , Karl H. Schoenbach
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
Abstract translation: 提供了通过施加纳秒脉冲电场（“nsPEF”）治疗实体皮肤肿瘤的新的无药物治疗方法。 在本发明的一个实施方案中，细胞是黑素瘤细胞，并且所应用的nsPEFs渗透到肿瘤细胞的内部并使肿瘤细胞核迅速收缩并且肿瘤血流停止。 这种新技术提供了高度定位的肿瘤细胞靶向，对上覆皮肤仅起微量的作用。
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