公开(公告)号：US20110213163A2

公开(公告)日：2011-09-01

申请号：US12812575

申请日：2009-01-16

申请人： Fumitoshi KAKIUCHI ,  Jun OGUMA

发明人： Fumitoshi KAKIUCHI ,  Jun OGUMA

IPC分类号： C07D409/14

CPC分类号： H01L51/0068 ,  C07D333/18 ,  H01L51/0062 ,  H01L51/0065 ,  H01L51/0067 ,  H01L51/0069 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/5048

摘要： A compound represented by the following formula (1): wherein Ar1, Ar2 and Ar3 each independently represent an aryl group or a monovalent heterocyclic group; the aryl group or the monovalent heterocyclic group represented by Ar1 has an aryl group, a monovalent alicyclic hydrocarbon group or a monovalent heterocyclic group at one position adjacent to the atom that forms Ar1 and is bonded to a carbon atom forming the benzene ring Q; the aryl group or the monovalent heterocyclic group represented by Ar2 has an aryl group, a monovalent alicyclic hydrocarbon group or a monovalent heterocyclic group at one position adjacent to the atom that forms Ar2 and is bonded to a carbon atom forming the benzene ring Q; the aryl group or the monovalent heterocyclic group represented by Ar3 has an aryl group, a monovalent alicyclic hydrocarbon group or a monovalent heterocyclic group at one position adjacent to the atom that forms Ar3 and is bonded to a carbon atom forming the benzene ring Q.

公开(公告)号：US20110166041A1

公开(公告)日：2011-07-07

申请号：US12999124

申请日：2009-06-25

申请人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

发明人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

IPC分类号： C40B40/06 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Disclosed are: a method for using a particular microRNA as a biomarker for gynecological cancer; a method for the determination of gynecological cancer; a kit for the determination of gynecological cancer, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-592, miR-629*, miR-517a, miR-205, miR-184, miR-509-5p, miR-135a*, miR-137, miR-602, miR-186*, miR-181a-2*, miR-193b*, miR-377*, miR-449b, miR-449a, miR-369-3p, miR-323-3p, miR-329, miR-299-5p, miR-34b, miR-411, miR-34c-5p, miR-376b, miR-885-5p, miR-337-3p, miR-337-5p, miR-127-3p, miR-138, miR-203, miR-488, miR-489, miR-643, miR-888, miR-424, miR-432, miR-433, miR-450a, miR-503, miR-542-3p, miR-542-5p and miR-584 is used as a biomarker for gynecological cancer.

摘要翻译： 公开的是：使用特定微小RNA作为妇科癌症生物标志物的方法; 确定妇科癌症的方法; 用于确定妇科癌症的试剂盒等。 本发明的特征在于，至少一种选自miR-592，miR-629 *，miR-517a，miR-205，miR-184，miR-509-5p，miR-135a * ，miR-137，miR-602，miR-186 *，miR-181a-2 *，miR-193b *，miR-377 *，miR-449b，miR-449a，miR-369-3p，miR-323-3p ，miR-329，miR-299-5p，miR-34b，miR-411，miR-34c-5p，miR-376b，miR-885-5p，miR-337-3p，miR-337-5p，miR-127 -3p，miR-138，miR-203，miR-488，miR-489，miR-643，miR-888，miR-424，miR-432，miR-433，miR-450a，miR-503，miR-542 -3p，miR-542-5p和miR-584用作妇科癌症的生物标志物。

公开(公告)号：US07965871B2

公开(公告)日：2011-06-21

申请号：US11826265

申请日：2007-07-13

申请人： Toru Ihara ,  Keiichi Yamamoto ,  Tomoaki Teshima ,  Hideo Saito ,  Shinji Ozawa

发明人： Toru Ihara ,  Keiichi Yamamoto ,  Tomoaki Teshima ,  Hideo Saito ,  Shinji Ozawa

IPC分类号： G06K9/00

CPC分类号： G06K9/00791 ,  B60W40/109 ,  G06K9/32 ,  G06K2009/363

摘要： A moving-state determining device acquires a first overhead image from a bird's-eye image obtained at first image pickup timing and acquires a second overhead image, which can be regarded as the same road surface area as that of the first overhead image, for each of moving directions assumed for the moving body from a bird's-eye image obtained at second image pickup timing different from the first image pickup timing by a predetermined time period. The device compares a degree of similarity between the first overhead image and each of a plurality of second overhead images to acquire the second overhead image with the largest similarity degree as the same road surface area as that of the first overhead image. The device acquires the moving direction and a lateral displacement amount in the moving from a coordinate conversion condition based on which the second overhead image has been obtained.

摘要翻译： 移动状态决定装置从在第一图像拍摄定时获得的鸟瞰图像中取得第一俯瞰图像，并获取与第一俯仰图像相同的道路面积的第二俯瞰图像 从与第一图像拾取定时不同的第二图像拾取定时获得的鸟瞰图像预测移动体的移动方向预定的时间段。 该装置比较第一开销图像与多个第二开销图像中的每一个之间的相似度，以获得具有最大相似度的第二开销图像作为与第一俯瞰图像相同的路面积。 该装置从获得第二俯瞰图像的坐标转换条件获取移动中的移动方向和横向位移量。

公开(公告)号：US07955789B2

公开(公告)日：2011-06-07

申请号：US11666337

申请日：2005-11-17

申请人： Yotaro Izumi ,  Masafumi Kawamura ,  Koichi Kobayashi

发明人： Yotaro Izumi ,  Masafumi Kawamura ,  Koichi Kobayashi

IPC分类号： A01N1/00

CPC分类号： A61K31/785 ,  A61L31/06 ,  A61L31/148 ,  C08L77/04

摘要： An object of the present invention is to provide an adhesion-preventing material which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and produced with ease and has high practical utility, as well as to a process for preventing adhesion by using the adhesion-preventing material.The present invention provides (1) an adhesion-preventing material comprising a crosslinked water absorbent poly-γ-glutamic acid as an effective ingredient; (2) the adhesion-preventing material described above, wherein the crosslinked water absorbent poly-γ-glutamic acid is in the form of powder having a water absorption coefficient in the range of 800-2000; (3) a process for preventing organ from adhesion, comprising a step of bringing the adhesion-preventing material described above into contact with the surface of a local organ; and (4) the process for preventing adhesion described above, wherein the surface of the local organ is in wet state.

摘要翻译： 本发明的目的是提供一种能够有效地防止器官表面附着的粘附防止材料，并且能够以高安全性容易地吸收身体并具有很高的实用性 关于通过使用防粘附材料防止粘合的方法。 本发明提供（1）一种防粘连材料，其包含交联吸水性聚-γ-谷氨酸作为有效成分; （2）上述的防粘附材料，其中交联吸水性聚-γ-谷氨酸为水分吸收系数为800〜2000的粉末形式; （3）防止器官粘连的方法，包括使上述的防粘连材料与局部器官的表面接触的工序; 和（4）上述用于防止粘连的方法，其中局部器官的表面处于湿润状态。

公开(公告)号：US20110123193A1

公开(公告)日：2011-05-26

申请号：US13054876

申请日：2009-07-03

申请人： Naoaki Yamanaka ,  Yutaka Arakawa ,  Kazumasa Tokuhashi

发明人： Naoaki Yamanaka ,  Yutaka Arakawa ,  Kazumasa Tokuhashi

IPC分类号： H04J14/00

CPC分类号： H04Q11/0067 ,  H04L12/2869 ,  H04Q2011/0041 ,  H04Q2011/0064 ,  H04Q2011/0079 ,  H04Q2011/0088

摘要： In an access network using optical switches, communications between an OLT and ONUs are established without a photoelectric conversion performed at an optical switching unit.The OLT controls the downlink optical switch SW(DOWN) to sequentially select each ONU in slots arranged in a discrete manner, and transmits a Discovery Gate message. Upon receipt of the Discovery Gate message, each ONU consecutively transmits Register Request messages. The uplink optical switch SW(UP) sequentially switch signals from ONU#1 through ONU#128 in the slots arranged in a discrete manner, and outputs the signals to the OLT, Some of the Register Requests transmitted from the respective ONUs pass through the SW(UP), and reach the OLT. Based on the received Register Requests, the OLT determines the timing of transmission for the ONUS, and notifies the ONUS of the timing of transmission through a Gate message.

摘要翻译： 在使用光交换机的接入网络中，OLT和ONU之间的通信建立，而不在光开关单元处执行光电转换。 OLT控制下行光纤交换机SW（DOWN），以离散方式排列的时隙顺序选择每个ONU，并发送发现门信息。 在接收到发现门消息时，每个ONU连续发送注册请求消息。 上行链路光开关SW（UP）以离散方式顺序地切换来自ONU＃1至ONU＃128的信号，并将该信号输出到OLT，从各个ONU发送的一些寄存器请求通过SW （UP），并到达OLT。 根据收到的注册请求，OLT确定ONUS的传输时序，并通过Gate消息向ONUS通知传输的定时。

公开(公告)号：US20110102015A1

公开(公告)日：2011-05-05

申请号：US12995757

申请日：2009-06-24

申请人： Tadahiro Kuroda

发明人： Tadahiro Kuroda

IPC分类号： H03K19/173

CPC分类号： G11C5/02 ,  G11C8/12 ,  H01L23/48 ,  H01L25/18 ,  H01L2224/16145 ,  H01L2225/06527

摘要： In the electronic circuit device with stacked plural components of the same function, this invention enables to select an arbitrary component among plural components by a control element, without setting pre-determined identification information in each component. By installing a sequential logic circuit in each component, and changing a state of the sequential logic circuit by control data transmitted from the component stacked in a preceding stage or the control element, the state of the controlled component is set to a state that accepts a selection made by the control element.

摘要翻译： 在具有相同功能的堆叠多个部件的电子电路装置中，本发明能够通过控制元件选择多个部件中的任意分量，而不在每个部件中设置预定的识别信息。 通过在每个组件中安装顺序逻辑电路，并且通过从堆叠在前一级或控制元件中的组件发送的控制数据来改变顺序逻辑电路的状态，受控组件的状态被设置为接受 由控制元件做出的选择。

公开(公告)号：US07901678B2

公开(公告)日：2011-03-08

申请号：US11451488

申请日：2006-06-13

申请人： Jin Nakahara ,  Hiroaki Asou ,  Sadakazu Aiso

发明人： Jin Nakahara ,  Hiroaki Asou ,  Sadakazu Aiso

IPC分类号： A61K39/395

CPC分类号： A61K45/00 ,  C07K16/283

摘要： The present invention provides pharmaceutical compositions composing, as an active ingredient, a substance capable of activating the γ chain of Fc receptors (FcRγ) (provided that the substance is not an immunoglobulin for intravenous injection), and agents for stimulating myelinogenesis. The invention also provides agents for stimulating the differentiation of oligodendroglial precursor cells, agents for activating Fyn tyrosine kinase, and agents for stimulating the expression of myelin basic protein, all comprising a substance capable of activating FcRγ as an active ingredient. Further, the invention provides a method of detecting myelinogenetic oligodendroglias or precursor cells thereof which comprises using the expression of FcRγ in oligodendroglias or precursor cells thereof as an indicator.

摘要翻译： 本发明提供作为活性成分构成能够激活Fc受体（FcRγ）的γ链（前提是该物质不是用于静脉内注射的免疫球蛋白）的药物组合物和刺激髓鞘形成的药剂的药物组合物。 本发明还提供用于刺激少突神经母细胞前体细胞分化的药剂，用于激活Fyn酪氨酸激酶的药剂和用于刺激髓磷脂碱性蛋白质表达的试剂，全部包含能够激活FcRγ作为活性成分的物质。 此外，本发明提供了检测骨髓发生少突胶质细胞或前体细胞的方法，其包括使用少突胶质细胞中的FcRγ或其前体细胞的表达作为指标。

公开(公告)号：US20110003842A1

公开(公告)日：2011-01-06

申请号：US12865725

申请日：2009-01-30

申请人： Yusuke Tanigawara ,  Mitsuhiro Watanabe ,  Eri Arita ,  Akito Nishimuta ,  Yasuko Yamayoshi ,  Takeshi Matsuzaki ,  Shinji Sugimoto

发明人： Yusuke Tanigawara ,  Mitsuhiro Watanabe ,  Eri Arita ,  Akito Nishimuta ,  Yasuko Yamayoshi ,  Takeshi Matsuzaki ,  Shinji Sugimoto

IPC分类号： A61K31/4375 ,  C07C229/36 ,  C07C229/08 ,  G01N33/68 ,  A61P35/00

CPC分类号： A61K31/4745 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/6812 ,  G01N2800/52 ,  Y10S436/813 ,  A61K2300/00

摘要： Provided are a marker for determining sensitivity to an anticancer agent capable of distinguishing a therapeutic response of an individual patient and a novel means for a cancer therapy using the marker. The marker for determining sensitivity to an anticancer agent contains a substance in a metabolic pathway in which L-phenylalanine and/or N,N-dimethyl glycine are/is involved.

摘要翻译： 提供了用于确定对能够区分各个患者的治疗反应的抗癌剂的敏感性的标记和使用该标记的癌症治疗的新手段。 用于确定对抗癌剂的敏感性的标记物含有涉及L-苯丙氨酸和/或N，N-二甲基甘氨酸的代谢途径中的物质。

公开(公告)号：US07860358B2

公开(公告)日：2010-12-28

申请号：US11988308

申请日：2006-02-10

申请人： Hiroyuki Tsuda ,  Mitsuhiro Yasumoto

发明人： Hiroyuki Tsuda ,  Mitsuhiro Yasumoto

IPC分类号： G02B6/26 ,  G02B6/42

CPC分类号： G02F1/3132 ,  G02B6/2813 ,  G02B6/354

摘要： It is an object of the present invention to provide a multimode interference waveguide type optical switch that has a wide tolerance and that digitally performs switching with respect to a change in an applied voltage or injected current. The multimode interference waveguide type optical switch of the present invention includes an input single-mode waveguide (102) into which input light is entered, a multimode rectangular slab waveguide (103) into which light emitted from the input single-mode waveguide is entered, two electrodes (105a, 105b) that are arranged in parallel in a waveguide direction on the slab waveguide and that decrease the refractive index of the slab waveguide (103) disposed thereunder by injecting current or applying voltage, and a plurality of output single-mode waveguides (104a, 104b) into which light emitted from the slab waveguide (103) is entered and from which output light is emitted.

摘要翻译： 本发明的目的是提供一种具有宽公差并相对于施加电压或注入电流的变化进行数字执行切换的多模干涉波导型光开关。 本发明的多模干涉波导型光开关包括输入光的输入单模波导（102），从输入单模波导发射的光进入的多模矩形平板波导（103） 在平板波导上沿波导方向平行布置的两个电极（105a，105b），并且通过注入电流或施加电压降低设置在其下方的平板波导（103）的折射率，以及多个输出单模 波导（104a，104b），其中从平板波导（103）发射的光进入其中，从中输出输出光。

公开(公告)号：US20100204435A1

公开(公告)日：2010-08-12

申请号：US12676329

申请日：2008-09-02

申请人： Hiroki Ebata ,  Shuichi Matsumura

发明人： Hiroki Ebata ,  Shuichi Matsumura

IPC分类号： C08G63/06

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/823

摘要： Manufacture, at a high yield, a new, biodegradable 12-hydroxy acid copolymer being a non-petroleum material and contributing to prevention of environmental pollution and global warming, from materials that include 12-hydroxystearic acid or derivative thereof obtained by hydrogenating ricinoleic acid which in turn is obtained from castor oil, as well as long-chain hydroxy acid that can be synthesized from plant-based seed oil, by using an immobilized lipase as a catalyst.

摘要翻译： 以高产率生产一种新的可生物降解的12羟基酸共聚物，它是一种非石油材料，有助于防止环境污染和全球变暖，包括通过氢化蓖麻油酸得到的12-羟基硬脂酸或其衍生物 又可以通过使用固定化的脂肪酶作为催化剂从蓖麻油以及可由植物种子油合成的长链羟基酸获得。