公开(公告)号：US5021586A

公开(公告)日：1991-06-04

申请号：US331345

申请日：1989-03-31

申请人： James P. Albarella ,  Nan-Horng Lin

发明人： James P. Albarella ,  Nan-Horng Lin

IPC分类号： C01B17/45 ,  C01B25/10 ,  C07D409/14 ,  C08G61/10 ,  C08G61/12 ,  H01B1/12

CPC分类号： C07D409/14 ,  C08G61/123 ,  H01B1/127

摘要： The present invention relates to a number of innovative electrophilic substitution reactions involving 2,5-dithienylpyrrole (2,5-DTP). More specifically, these reactions are used in the synthesis of monomers for preparing functionalized conducting organic polymers.The elctrophilic substitution reactions in this invention are accomplished under conditions not requiring the use of N-1 pyrrole blocking groups to direction reaction at the pyrrole C-3 position. This is because the steric bulk of the 2,5-dithienyl groups prevent N-acylation and therefore direct reactions with electrophiles at the pyrrole C-3 position.The reaction conditions chosen have also demonstrated a greater regioselectively towards functionalization at the pyrrole 3-position than the basic reaction conditions suggested in the prior art. This result may be explained by an activation of the pyrrole 3-position towards electrophilic substitution. This is attributed to an electron donating resonance contribution of the 2,5 thienyl groups.Other advantageous reaction conditions have been discovered which direct electrophilic substitution preferentially at the pyrrole or thiophene groups depending upon the amount of acidic catalyst.

公开(公告)号：US5008077A

公开(公告)日：1991-04-16

申请号：US457106

申请日：1989-12-26

申请人： Mohammad A. Kheiri

发明人： Mohammad A. Kheiri

IPC分类号： G01N31/22 ,  G01N33/52

CPC分类号： G01N33/521 ,  Y10S435/805

摘要： An easily grasped reagent strip is disclosed. The reagent strip includes a handle that is elevated or spaced from a flat surface on which the reagent strip is placed. The handle is formed or bent to extend laterally from the rest of the reagent strip. Alternatively, ribs or buttons may be formed in the handle of the reagent strip to space the handle from a flat surface. The reagent strip can also include informative tactile indicia such as braille to inform a visually impaired or blind person of the type of reagent strip and the location of the reagent pad on the strip.

公开(公告)号：US4999304A

公开(公告)日：1991-03-12

申请号：US138096

申请日：1987-12-28

申请人： Steven Robertson

发明人： Steven Robertson

IPC分类号： G01N33/48 ,  A61B5/145 ,  B04B5/00 ,  G01N21/07

CPC分类号： G01N21/07 ,  Y10T436/111666 ,  Y10T436/25375 ,  Y10T436/25625

摘要： A centrifuge for separating constituents of fluids, diluting the constituents and inoculating a reagent includes a spinning assembly for spinning a processor member. The processor member includes fluid and diluent compartments, separation chambers for a fluid and for a diluent, a mixing chamber, and a reagent chamber. The fluid compartment is in communication with the fluid separation chamber by a first passage. The diluent compartment and diluent separation chamber are communicated by a second passage. The first and second passages are oriented such that centrifugal force moves the fluid and diluent through the first and second passages into the respective chambers. The chambers are aligned to prevent outflow under the influence of centrifugal force but to allow outflow into measuring passages upon braking the spinning of the processor member. Spinning the processor member after braking generates a centrifugal force moving the fluid and diluent through the measuring passages into a mixing chamber. Braking the spinning of the processor member again applies a braking force on the mixed fluid and diluent moving this mixture into the reagent chamber.

公开(公告)号：US4996332A

公开(公告)日：1991-02-26

申请号：US205732

申请日：1988-06-13

申请人： Robert T. Buckler ,  Robert P. Hatch

发明人： Robert T. Buckler ,  Robert P. Hatch

IPC分类号： C07D215/54 ,  C07D311/20 ,  C12Q1/28

CPC分类号： C07D311/20 ,  C07D215/54 ,  C12Q1/28

摘要： Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

摘要翻译： 对氧化剂（例如过氧化氢）有响应的光学指示剂硫属化合物（硒化物或硫化物）以及制备和使用这些指示剂的方法。 氧化后，得到的中间体自发消除硫族元素残余物，产生提供光信号如荧光的信号化合物。 优选的荧光指示剂化合物是3-硫族原-3,4-二氢香豆素衍生物和3-硫族原-3,4-二氢-2-喹诺酮衍生物。 这种指示剂化合物在通过过氧化氢氧化时提供高度荧光的产物，并且可用于响应于待测分析物产生过氧化氢的分析系统。

公开(公告)号：US4994269A

公开(公告)日：1991-02-19

申请号：US325329

申请日：1989-03-17

申请人： Michael S. Collins ,  Nirmal S. Mehton

发明人： Michael S. Collins ,  Nirmal S. Mehton

IPC分类号： A61K38/00 ,  C07K16/12

CPC分类号： C07K16/12 ,  A61K38/00 ,  Y10S424/808

摘要： Method of preventing or treating a Pseudomonas aeruginosa infection. Method comprises topical application of antibodies to P. aeruginos under conditions and in an amount sufficient to prevent or treat the infection in a mammal. In one embodiment, the antibodies are administrered in form of an aerosol. A preferred dosage for polyclonal antibody preparations (i.e. ISG or high titer P. aeruginosa ISG) ranges from 2 mg/kg to 100 mg/kg body weight of the mammal. A preferred monoclonal antibody dosage ranges from 0.02 to 1.0 mg/kg of body weight.

摘要翻译： 预防或治疗铜绿假单胞菌感染的方法。 方法包括在足以预防或治疗哺乳动物感染的条件和量下局部施用对绿脓杆菌的抗体。 在一个实施方案中，抗体以气雾剂的形式施用。 多克隆抗体制剂（即ISG或高滴度铜绿假单胞菌ISG）的优选剂量为哺乳动物体重的2mg / kg至100mg / kg。 优选的单克隆抗体剂量范围为0.02至1.0mg / kg体重。

公开(公告)号：US4994057A

公开(公告)日：1991-02-19

申请号：US432431

申请日：1989-11-06

申请人： Raleigh A. Carmen ,  Chi-Yong Chong

发明人： Raleigh A. Carmen ,  Chi-Yong Chong

IPC分类号： A61J1/05 ,  A61J1/00 ,  A61J1/10 ,  A61J1/20 ,  A61L2/07 ,  A61L2/10

CPC分类号： A61L2/07 ,  A61J1/067 ,  A61J1/10 ,  A61J1/2089 ,  A61J1/2027 ,  A61J1/2037

摘要： An improved heat sterilizable blood bag system adapted for containing and mixing of different materials originally placed in separate but potentially communicating compartments. The improvement comprises of having a smaller squeezable compartment for one material attached to and capable of communicating with a larger compartment for the other material. The material in the smaller compartment is separated from the interior of the larger compartment by means of an externally manipulatable closure means which, when opened, permits mixture of the contents in the first compartment and contents of the second compartment when the smaller compartment is repeatedly squeezed.

摘要翻译： 一种改进的可热灭菌血袋系统，适用于容纳和混合最初放置在单独但潜在连通的隔室中的不同材料。 该改进包括具有较小的可挤压隔间，用于连接到并能够与用于其它材料的较大隔间连通的一种材料。 较小隔间的材料通过外部可操纵的封闭装置从较大隔间的内部分离，当封闭装置打开时，当较小的隔室被重复挤压时，允许混合第一隔室中的内容物和第二隔室的内容物 。

公开(公告)号：US4981653A

公开(公告)日：1991-01-01

申请号：US254165

申请日：1988-10-06

申请人： Rebecca A. Marino

发明人： Rebecca A. Marino

IPC分类号： G01N33/52

CPC分类号： G01N33/521 ,  G01N33/525 ,  Y10S435/804 ,  Y10S436/81

摘要： The present invention relates generally to an analytical reagent test strip for assaying fluid samples. The reagent test strip of this invention has a self-indicating format which provides accurate and reliable results without the need for a color chart or instrument analysis. In the preferred embodiment of this invention, reagent threads are incorporated into and protrude through a polymer housing. The threads are placed in a particular pattern whereby different colored configurations will occur in response to different concentrations of analyte in a sample. The present invention is accurate, reliable and convenient to use.

摘要翻译： 本发明一般涉及用于测定流体样品的分析试剂测试条。 本发明的试剂测试条具有自我指示格式，其提供准确可靠的结果，而不需要彩色图表或仪器分析。 在本发明的优选实施方案中，试剂丝被并入聚合物外壳并穿过聚合物壳体。 螺纹被放置在特定的图案中，由此响应于样品中不同浓度的分析物而发生不同的着色构型。 本发明使用准确，可靠，使用方便。

公开(公告)号：US4970171A

公开(公告)日：1990-11-13

申请号：US118476

申请日：1987-11-09

申请人： Lowry Messenger ,  Frances M. Yeager ,  Kin F. Yip

发明人： Lowry Messenger ,  Frances M. Yeager ,  Kin F. Yip

IPC分类号： A61B5/145 ,  A61B5/1459 ,  G01N33/53 ,  G01N33/543 ,  G01N33/66 ,  G01N33/72

CPC分类号： G01N33/54346 ,  G01N33/723 ,  Y10S436/808 ,  Y10T436/107497

摘要： An analytical method for determining the relative amount of a particular hemoglobin derivative, e.g., glycated hemoglobin, in a blood sample wherein the amounts of both total hemoglobin and the hemoglobin derivative are measured and related mathematically, e.g., as a percentage. The blood sample is treated with the combination of a thiocyanate salt and an oxidant to denature the hemoglobin in the sample and to convert hemoglobin to met-hemoglobin. Met-hemoglobin is measured spectrophotometrically to give the amount of total hemoglobin present, and the denatured hemoglobin derivative can be distinguished and measured by immunoassay. The presence of the oxidant in the denaturant solution has been found to increase the rate of enaturation of hemoglobin thereby reducing the overall assay time and improving the reliability of the determination.

公开(公告)号：US4968630A

公开(公告)日：1990-11-06

申请号：US388813

申请日：1989-08-03

申请人： Steven C. Charlton ,  James B. Denton

发明人： Steven C. Charlton ,  James B. Denton

IPC分类号： G01N31/00 ,  G01N31/22 ,  G01N33/84

CPC分类号： G01N33/84

摘要： A method and apparatus for determining lithium ion concentrations in an aqueous sample are provided wherein the selectivity is improved by the addition of orotic acid. The orotic acid precipitates sodium and potassium ions which can interfere with the lithium ion determination.

公开(公告)号：US4965013A

公开(公告)日：1990-10-23

申请号：US345972

申请日：1989-05-01

申请人： Karen L. Pratt

发明人： Karen L. Pratt

IPC分类号： D06B23/00 ,  C11D3/20 ,  D06L1/12

CPC分类号： C11D3/2086

摘要： Disclosed is a fabric cleaning process which involves contacting the fabric with a cleaning solution comprising an anionic detergent and sodium citrate as detergent builder at a temperature above about 70.degree. C.