公开(公告)号：US20210242648A1

公开(公告)日：2021-08-05

申请号：US17048711

申请日：2019-04-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Nir DAVIDSON ,  Asher FRIESEM ,  Oren RAZ ,  Chene TRADONSKY

IPC: H01S3/00 ,  H01S3/06 ,  H01S3/08 ,  H01S3/083 ,  H01S3/105 ,  H01S3/106 ,  H01S3/10

Abstract: Laser systems and methods configured to reconstruct an image of an object from an input comprising: the objects scattered intensity distribution (SID) and the objects compact support; the system comprising: a first lens and a second lens, in a four-focal telescope configuration; a gain with a minor at one end, at first end of the telescope, configured to amplify and reflect a received beam; a reflective spatial light modulator, at second end of the telescope, configured to selectively reflect intensity distributions of a received beam, according to their spatial location, the selective reflection is configured to maintain the intensity distributions of the objects SID; a spatial intensity binary mask, located between the telescope's lenses, comprising an aperture in the form of the objects compact support; the mask is configured to transfer only beams passing through the aperture. The reconstructed objects image is provided at least at the mask's aperture.

公开(公告)号：US11077128B2

公开(公告)日：2021-08-03

申请号：US16847737

申请日：2020-04-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: A61K31/7052 ,  C07H17/00 ,  C07J43/00 ,  A61P27/06 ,  A61P9/00 ,  C07J19/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

公开(公告)号：US20210230597A1

公开(公告)日：2021-07-29

申请号：US17227483

申请日：2021-04-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Orna ISSLER

IPC: C12N15/113 ,  C12N15/11 ,  C12Q1/6883

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

公开(公告)号：US11047855B2

公开(公告)日：2021-06-29

申请号：US15555258

申请日：2016-02-29

Applicant: IMMUNARRAY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rachel Sorek ,  Keren Jakobi ,  Pennina Safer ,  Anat Reiner-Benaim ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/68 ,  G16B40/00

Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

公开(公告)号：US11037031B2

公开(公告)日：2021-06-15

申请号：US16788661

申请日：2020-02-12

Applicant: Beijing Horizon Robotics Technology Research and Development Co., Ltd.

Inventor： Chaoxu Guo ,  Qian Zhang ,  Guoli Wang ,  Chang Huang

IPC: G06K9/62 ,  G06N3/04

Abstract: An image recognition method includes: determining a first feature map of the current frame image by using a convolutional neural network based on a type of a current frame image; determining a second feature map of a key frame image before the current frame image; performing feature alignment on the first feature map and the second feature map to obtain a first aligned feature map; fusing the first feature map and the first aligned feature map to obtain a first fused feature map; and recognizing content in the current frame image based on the first fused feature map.

公开(公告)号：US11035858B2

公开(公告)日：2021-06-15

申请号：US16082296

申请日：2017-03-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yifat Merbl ,  Hila Wolf-Levy ,  Yishai Levin ,  Bareket Dassa

IPC: G01N33/00 ,  G01N33/573 ,  C12Q1/37 ,  G01N33/50

Abstract: A method of isolating barrel-like proteases is disclosed. The method comprising isolating barrel-like proteases from a biological sample containing the barrel-like proteases under conditions that maintain the content of the barrel-like protease-processed peptides in the barrel-like proteases upon isolation. A method of isolating barrel-like protease-processed peptides and a method of identifying barrel-like protease-processed peptides are also disclosed.

公开(公告)号：US11028127B2

公开(公告)日：2021-06-08

申请号：US16704010

申请日：2019-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Moshe Oren ,  Varda Rotter ,  Perry Tal

IPC: C07K14/00 ,  C07K14/47 ,  C07K7/06 ,  A61K38/16 ,  A61K38/08 ,  C07K7/08 ,  A61K38/00

Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.

公开(公告)号：US20210115092A1

公开(公告)日：2021-04-22

申请号：US17254932

申请日：2019-06-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef SHAUL ,  Nina REUVEN

IPC: C07K14/005 ,  C12N9/22 ,  C12N7/00 ,  C12N15/11 ,  A61K38/46 ,  A61K31/7088 ,  C12N15/90

Abstract: A recombinant system for improving genome editing via homologous recombination is disclosed. The system comprising a first nucleic acid sequence encoding a DNA editing agent having a double strand DNA cutting activity and a second nucleic acid sequence encoding a polypeptide capable of increasing homologous recombination in a target cell.

公开(公告)号：US20210089692A1

公开(公告)日：2021-03-25

申请号：US17026505

申请日：2020-09-21

Applicant: Shanghai Volvo Car Research and Development Co., Ltd.

Inventor： Anders Sandahl ,  Tao NI

IPC: G06F30/20 ,  G06F30/15

Abstract: A simulation method related with the opening force of a front vehicle door after a vehicle frontal collision including: a first simulation step in which deformations of vehicle components which are caused in the vehicle frontal collision to affect the opening of the front door are calculated by simulation; and a second simulation step in which the opening force of the front door after the vehicle frontal collision is predicted by simulation; wherein the components which affect the opening of the front door include a design component and an interface component, the deformations of the design component and the interface component obtained in the first simulation step being used as initial geometric conditions of the design component and the interface component in the second simulation step.

公开(公告)号：US10926502B2

公开(公告)日：2021-02-23

申请号：US16307112

申请日：2018-06-14

Applicant: ZHONGKEJUXIN CLEAN ENERGY & HOT FORGING EQUIPMENT RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Lianhua Zhang ,  Hui Zhang

IPC: F15B1/04 ,  B30B15/16 ,  F15B15/14 ,  F15B15/20

Abstract: Provided are an efficient energy-saving return cylinder of a hydraulic press and a working method thereof. The efficient energy-saving return cylinder of a hydraulic press comprises a plurality of single-rod return hydraulic cylinders symmetrically distributed at two sides of a main hydraulic cylinder of the hydraulic press, the plurality of single-rod return hydraulic cylinders are divided into several groups, each of the groups consisting of one balancing cylinder and one driving cylinder; a rod chamber of the balancing cylinder is communicated with an accumulator, the pressurized oil in the accumulator is filled into an oil chamber of the balancing cylinder, so that the balancing cylinder balances the weight of a walking beam and a working part of the walking beam; the driving cylinder is differentially connected; in the process of neutral-stroke-rapid-descending and ascending-returning of the walking beam and the working part of the walking beam.