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91.发明申请公开(公告)号：US20220079158A1
公开(公告)日：2022-03-17
申请号：US17532465
申请日：2021-11-22
IPC分类号： A01N59/00 , A01N65/00 , A01N65/08 , A01N65/22 , A01N65/44 , A01N65/34 , A01N65/36 , A01N65/38 , A01N65/24
摘要： Compositions and methods that utilize a combination of essential oils or other plant-derived extracts or compounds and an emulsifier as an antimicrobial are provided. In some embodiments the compositions further include ozone. In some embodiments, the composition includes one or more plant essential oils, plant extracts, or plant-derived compounds, or combinations thereof, and an emulsifier (such as a saponin). The antimicrobial composition may also include water, peracetic acid, acetic acid, lactic acid, citric acid, and/or hydrogen peroxide. Methods of killing a microorganism, including contacting the microorganism with the disclosed antimicrobial compositions are also provided. The microorganism may be present on a food item or a food contact of non-food contact surface and may be in the form of a biofilm. In some examples, the antimicrobial composition is used one or more times (such as 1 to 5 times).
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公开(公告)号：US11274915B2
公开(公告)日：2022-03-15
申请号：US17052448
申请日：2019-04-29
发明人： Stanley Pau , Rongguang Liang
IPC分类号： G01B9/02 , G01B11/24 , G01B11/30 , G01B9/02001 , G02B5/20
摘要： Methods, devices and systems are described that use a combination multiple light sources having different coherence lengths to measure surface characteristics of an object. One example system includes a two laser sources configured to operate at a first and a second center wavelength, a broadband source configured to operate at a range of wavelengths outside of the operating range of the at least two lasers, a phase mask array and a color filter arranged, respectively, to impart different phase delays and provide spectral filtering corresponding to the emitted radiation from the sources. A pixelated sensor device is positioned to simultaneously measure intensity values associated with a plurality of interferograms formed due to interference of light from the light sources after propagation through the phase mask array and the color filter. The measured intensity values enable the determination of surface characteristics of the object.
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公开(公告)号：US20220024978A1
公开(公告)日：2022-01-27
申请号：US17499464
申请日：2021-10-12
发明人： Victor J. Hruby , Aswini K. Giri
IPC分类号： C07K7/06
摘要： The present invention relates generally to a compound having both agonist activity at opioid receptor(s) and antagonist activity at NK1 receptor, and methods for producing and using the same. This combination of activities provides several synergistic and/or beneficial effects such as enhanced potency in analgesic effect and reduction or inhibition of tolerance.
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公开(公告)号：US20220017969A1
公开(公告)日：2022-01-20
申请号：US17311538
申请日：2019-12-06
IPC分类号： C12Q1/6886 , C07K14/705
摘要： The present invention relates to a method of using family and/or regulatory members of the PD-1/PD-L1 pathway as predictive markers for risk of skin cancer development and as targets for therapeutic prevention of pre-malignant (or pre-cancerous) skin lesions and non-melanoma skin cancer (NMSC). This invention will allow for quantitative measurements of UV-induced expression of PD-1/PD-Li signaling pathway family members (e.g., PD-1, PD-L1, PD-L2) and/or PD-1/PD-L1 regulatory factors including AP-1 and NFκB family members in skin tissue of individuals to determine an individual's 1) risk for skin cancer development and 2) appropriate prophylactic treatment strategy to prevent skin cancer development. This information will facilitate identification of those patients at risk for pre-malignant (or pre-cancerous) skin lesions or subsequent NMSC lesions who would benefit from a PD-1/PD-L1 pathway suppressing therapy to prevent skin cancer development.
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公开(公告)号：US20220017556A1
公开(公告)日：2022-01-20
申请号：US17489477
申请日：2021-09-29
发明人： Jeanne E. Pemberton , Tyler Roberts
摘要： The present disclosure discusses methods for producing stereoisomerically enriched carbohydrate-based surfactants. In particular, methods of the invention include producing stereoisomerically enriched hydrophobic portion of the carbohydrate-based surfactants.
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公开(公告)号：US11215563B2
公开(公告)日：2022-01-04
申请号：US16310685
申请日：2017-06-09
发明人： Tsu-Te Judith Su , Euan McLeod
IPC分类号： G02B6/12 , G01N21/77 , G02B6/122 , G01N21/552 , B82Y20/00 , G01N33/543
摘要： An optical microtoroid resonator including one or more nanoparticles attached to a surface of the resonator and capable of receiving an input signal from a far-field source (via free-space transmission) and outputting light propagating within the optical apparatus. A method for coupling light into and out of an optical resonator using a nanoparticle or nanoparticles to interface with spatially separated far-field optical elements.
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97.发明申请公开(公告)号：US20210398010A1
公开(公告)日：2021-12-23
申请号：US17351873
申请日：2021-06-18
申请人： Arizona Board of Regents on Behalf of the University of Arizona, a body corporate , NICOLAUS COPERNICUS UNIVERSITY IN TORÚN
IPC分类号： G06N10/00
摘要： A method for determining a perturbation energy of a quantum state of a many-body system includes constructing a wave function that approximates the quantum state by adjusting parameters of the wave function to minimize an expectation value of a zeroth-order Hamiltonian. The zeroth-order Hamiltonian explicitly depends on a finite mass of each of a plurality of interacting quantum particles that form the many-body system, the quantum state has a non-zero total angular momentum, the wave function is a linear combination of explicitly correlated Gaussian basis functions, and each of the explicitly correlated Gaussian basis functions includes a preexponential angular factor. The perturbation energy is calculated from the wave function and a perturbation Hamiltonian that explicitly depends on the finite mass of each of the plurality of interacting quantum particles. The perturbation energy may be added to the minimized expectation value to obtain a total energy of the quantum state.
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公开(公告)号：US11204509B2
公开(公告)日：2021-12-21
申请号：US17290163
申请日：2019-10-30
发明人： Dae Wook Kim , Rongguang Liang , Oliver Spires
摘要： A kinematically engaged yoke system (KEYS) for multiple-order-diffraction engineered material may comprise a harness comprising a frame and a plurality of semi-kinematic keys disposed on the frame, wherein the semi-kinematic keys are configured based on a MOD-side mechanical profile of a plurality of segments of a multiple-order-diffraction engineered material, and wherein the MOD-side mechanical profile, when engaged with the semi-kinematic keys, functions as a fiducial that provides alignment between neighboring segments; and one or more shims disposed between one or more pairs of neighboring segments of the plurality of segments of the multiple-order-diffraction engineered material, wherein the one or more shims facilitate alignment of the one or more pairs of neighboring segments of the plurality of segments based on a translation across one or more surfaces of the one or more shims.
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公开(公告)号：US11203618B2
公开(公告)日：2021-12-21
申请号：US16893667
申请日：2020-06-05
发明人： Lynn A. Joens , Bibiana Law , Alexandra Armstrong
IPC分类号： C07H21/04 , C07K14/205 , A61K39/02 , C12N15/74 , A61K39/00
摘要： The present disclosure provides immunogenic compositions against Campylobacter and methods for using the immunogenic composition to generate an immune response against Campylobacter and/or reduce intestinal colonization by Campylobacter.
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100.发明申请公开(公告)号：US20210389302A1
公开(公告)日：2021-12-16
申请号：US17345718
申请日：2021-06-11
IPC分类号： G01N33/50
摘要： Methods and systems for screening therapeutic compositions for the treatment of age-related macular degeneration (AMD) or for the prevention of progression of AMD, wherein retinal pigment epithelium cells (RPE) are cultured and the level of hypoxia-induced exosome release from the RPE cells is subsequently measured. In the present invention, the level of hypoxia-induced exosome release can be correlated with AMD onset and severity.
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