公开(公告)号：US4376864A

公开(公告)日：1983-03-15

申请号：US320131

申请日：1981-11-10

Applicant: Karlheinz Drauz ,  Axel Kleemann ,  Marc Samson

Inventor： Karlheinz Drauz ,  Axel Kleemann ,  Marc Samson

IPC: C07D207/16 ,  C07D317/30 ,  C07D319/06 ,  C07D405/06

CPC classification number: C07D207/16 ,  C07D317/30 ,  C07D319/06

Abstract: The invention is directed to cyclic acetals of glutamic acid-.gamma.-semialdehyde of the formula ##STR1## in which A is an unsubstituted alkylene group having 2 to 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups and to a method of producing a compound of formula (I) by reaction of a compound of the general formula ##STR2## in which A is as defined above with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and basic hydrolysis of the reaction mixture obtained and to using the compound of formula (I) to produce D,L-proline.

Abstract translation: 本发明涉及式（I）的谷氨酸-γ-甲醛的环状缩醛，其中A为未取代的具有2至3个碳原子的亚烷基或亚烷基被1至2个甲基取代， 涉及制备式（I）化合物的方法，其中通式为其中A定义如上所定义的化合物与氰化氢或氰化物离子供应化合物反应，提供氨或铵离子 化合物和二氧化碳或碳酸根离子供应化合物和所得反应混合物的碱性水解和使用式（I）化合物产生D，L-脯氨酸。

公开(公告)号：US4374995A

公开(公告)日：1983-02-22

申请号：US320128

申请日：1981-11-10

Applicant: Axel Kleemann ,  Marc Samson

Inventor： Axel Kleemann ,  Marc Samson

IPC: C07D403/06 ,  C07D209/20 ,  C07D233/76 ,  C07D233/30

CPC classification number: C07D209/20

Abstract: Tryptophane hydantoin is prepared by(a) reacting a compound of the general formula ##STR1## where A is an alkylene group having 2 or 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups in aqueous or aqueous alcoholic solution with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and(b) reacting the reaction mixture obtained with phenyl hydrazine at a pH between 0.1 and 4.

Abstract translation: 色氨酸乙内酰脲通过以下方法制备：（a）使具有2或3个碳原子的亚烷基或其中1至2个甲基取代的亚烷基的通式为（IMA）的化合物（I）与含水或含水醇 用氰化氢或氰化物离子供给化合物，氨或铵离子供给化合物和二氧化碳或碳酸根离子供给化合物的溶液，和（b）使得到的反应混合物与苯肼在0.1至4的pH下反应。

公开(公告)号：US4360697A

公开(公告)日：1982-11-23

申请号：US252609

申请日：1981-04-09

Applicant: Axel Kleemann ,  Robert Nygren ,  Rudolf Wagner

Inventor： Axel Kleemann ,  Robert Nygren ,  Rudolf Wagner

IPC: C07C67/00 ,  C07C213/00 ,  C07C213/04 ,  C07C215/10 ,  C07C89/02 ,  C07C91/10

CPC classification number: C07C213/04

Abstract: The production of 1-amino-propanediol-2,3 is attained with good yields and in an industrially simple manner by reacting liquid ammonia with glycidol under pressure in the presence of a small amount of an organic solvent.

Abstract translation: 通过在少量有机溶剂的存在下，在压力下使液氨与缩水甘油反应，以高产率和工业上简单的方式得到1-氨基 - 丙二醇-2,3的生产。

公开(公告)号：US4342874A

公开(公告)日：1982-08-03

申请号：US320130

申请日：1981-11-10

Applicant: Axel Kleemann ,  Marc Samson

Inventor： Axel Kleemann ,  Marc Samson

IPC: C07D405/06 ,  C07D209/20

CPC classification number: C07D209/20

Abstract: The invention is directed to 2-[2'-(hydanto-5-yl)-ethyl]-5,5-dimethyl-1,3-dioxane of the formula ##STR1## its production by reaction of 2-(2'-formylethyl)-5,5-dimethyl-1,3-dioxane with hydrogen cyanide or a cyanide ion supplying compound, ammonia, or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound in aqueous alcoholic solution and its use for the production of tryptophane-hydantoin.

Abstract translation: 本发明涉及式（I）的2- [2' - （乙烷基-5-基） - 乙基] -5,5-二甲基-1,3-二恶烷，其通过2-（ 2'-甲酰基乙基）-5,5-二甲基-1,3-二恶烷与氰化氢或氰化物离子供应化合物，氨或铵离子供应化合物和二氧化碳或碳酸根离子供应化合物在含水醇溶液中 用于生产色氨酸 - 乙内酰脲。

公开(公告)号：US4322552A

公开(公告)日：1982-03-30

申请号：US208022

申请日：1980-11-18

Applicant: Axel Kleemann ,  Jurgen Martens ,  Horst Weigel

Inventor： Axel Kleemann ,  Jurgen Martens ,  Horst Weigel

IPC: C07B61/00 ,  B01J23/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C237/00 ,  C07C237/06 ,  C07C102/00

CPC classification number: C07C237/00

Abstract: 4-aminobutyramide hydrochloride is produced by hydrogenation of 3-cyanopropionamide in the presence of a solvent inert under the reaction conditions, a noble metal catalyst and hydrogen chloride at a temperature between 5.degree. and 80.degree. C. The hydrochloride can be easily converted into 4-aminobutyramide which as such or in the form of derivatives has significance as a neurotransmitter.

Abstract translation: 4-氨基丁酰胺盐酸盐是在反应条件为惰性溶剂，贵金属催化剂和氯化氢的溶剂存在下，3-氰基丙酰胺在5-80℃的温度下氢化生成的。盐酸盐可以容易地转化为4 - 氨基丁酰胺，其原样或以衍生物的形式具有作为神经递质的意义。

公开(公告)号：US4197161A

公开(公告)日：1980-04-08

申请号：US618236

申请日：1975-09-30

Applicant: Heinz Friedrich ,  Wolfgang Heim ,  Axel Kleemann ,  Heinz Kolb ,  Gerd Schreyer

Inventor： Heinz Friedrich ,  Wolfgang Heim ,  Axel Kleemann ,  Heinz Kolb ,  Gerd Schreyer

IPC: B01J23/92 ,  C01G33/00 ,  C01G39/00 ,  C01G41/00 ,  C07D301/12 ,  C07D301/32 ,  C10G9/32

CPC classification number: C07D301/32 ,  B01J23/92 ,  C01G33/00 ,  C01G39/006 ,  C01G41/00 ,  C07D301/12 ,  Y02P20/584

Abstract: Catalysts used in the epoxidation or hydroxylation of water soluble olefinic compound with hydrogenperoxide are recovered by separating the catalyst as a distillation residue, the distillation residue is introduced into an inert material which is in whirling movement, e.g., as a fluidized bed, the organic compounds contained in the distillation residue are burned with oxygen or oxygen containing gases whereupon the catalyst compound separated on the inert whirling material together with the portion of the catalyst compound which accumulates in the solids separator connected at the outlet of the reactor is dissolved in water and the solution obtained again used for epoxidation or hydroxylation.

Abstract translation: 用于过氧化氢的水溶性烯烃化合物的环氧化或羟化反应的催化剂是通过将催化剂作为蒸馏残余物分离来回收的，将蒸馏残余物引入到旋转运动中的惰性物质中，例如作为流化床，有机化合物 蒸馏残余物中所含的物质被氧气或含氧气体燃烧，因此在惰性旋转材料上分离的催化剂化合物与积聚在反应器出口处连接的固体分离器中的催化剂化合物部分溶解在水中， 再次获得的溶液用于环氧化或羟基化。

公开(公告)号：US4161491A

公开(公告)日：1979-07-17

申请号：US802903

申请日：1977-06-02

Applicant: Axel Kleemann ,  Herbert Klenk ,  Werner Schwarze

Inventor： Axel Kleemann ,  Herbert Klenk ,  Werner Schwarze

IPC: C07C231/06 ,  C07C20060101 ,  C07C67/00 ,  C07C231/00 ,  C07C235/72 ,  C07C235/80 ,  C07C102/02 ,  C07C102/08 ,  C07C103/127 ,  C07C103/19

CPC classification number: C07C231/06

Abstract: There are prepared .alpha.-ketocarboxylic acid amides of the formula ##STR1## where R is hydrogen, R.sub.1 and R.sub.2 are the same or different, R.sub.1 is alkyl of 1 to 18 carbon atoms or haloalkyl, preferably chloroalkyl, of 1 to 18 carbon atoms, and R.sub.2 is hydrogen, alkyl of 1 to 18 carbon atoms or haloalkyl, preferably chloroalkyl, of 1 to 18 carbon atoms or ##STR2## together is a cycloalkyl group of 3 to 8 carbon atoms which can be substituted by one or more 1 to 5 carbon atom alkyl groups or by one or more halogen atoms, preferably chlorine atoms, with the proviso that when ##STR3## form a cycloalkyl group then R can also be alkyl of 1 to 5 carbon atoms. The process comprises saponifying an acyl cyanide of the formula ##STR4## in which R, R.sub.1 and R.sub.2 are as defined above in an organic solvent or mixture of such solvents which is liquid and inert under the reaction conditions, first with gaseous hydrogen chloride and then treating with water at a temperature of about -70.degree. C. to about +70.degree. C. and then isolating the .alpha.-ketocarboxylic acid amide in conventional manner. Several of the cyclic .alpha.-ketocarboxylic acid amides are new compounds.

Abstract translation: 制备式（I）的α-酮羧酸酰胺，其中R是氢，R 1和R 2相同或不同，R 1是1至18个碳原子的烷基或卤代烷基，优选氯代烷基，其为1至18 碳原子，R 2是氢，1至18个碳原子的烷基或具有1至18个碳原子的卤代烷基，优选氯代烷基，或者“IMAGE”是3-8个碳原子的环烷基，其可以被一个或多个 1至5个碳原子的烷基或一个或多个卤素原子，优选氯原子，条件是当形成环烷基时，则R也可以是1至5个碳原子的烷基。 该方法包括在其中R 1，R 2和R 2如上所定义的式（Ⅶ）的酰基氰在有机溶剂或这种在反应条件下为液体和惰性的溶剂的混合物中，首先用气态氢 然后在约-70℃至约+70℃的温度下用水处理，然后以常规方式分离α-酮羧酸酰胺。 几种环状α-酮羧酸酰胺是新的化合物。