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17 条记录 (耗时 0.014 秒)

    Cyclic acetals of N-acylglutamic acid-.gamma.-semialdehydes, process for their production and use
    1.
    发明授权
    Cyclic acetals of N-acylglutamic acid-.gamma.-semialdehydes, process for their production and use 失效
    N-酰基谷氨酸-γ-甲醛的环状缩醛，其生产和使用过程

    公开(公告)号：US4424370A

    公开(公告)日：1984-01-03

    申请号：US320129

    申请日：1981-11-10

    申请人： Axel Kleemann ,  Marc Samson

    发明人： Axel Kleemann ,  Marc Samson

    IPC分类号： C07D209/20 ,  C07D317/30 ,  C07D319/06 ,  C07D405/06

    CPC分类号： C07D209/20 ,  C07D317/30 ,  C07D319/06

    摘要： The invention is directed to a cyclic acetal of N-acylglutamic acid-.gamma.-semialdehyde of the formula ##STR1## in which A is an unsubstituted alkylene group having 2 to 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups and R is a methyl, methoxy, phenyl, or benzyloxy group and to a method of producing a compound of formula (I) by reaction of a compound of the general formula ##STR2## in which A is as defined above, with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and basic hydrolysis of the reaction mixture obtained and reaction of the hydrolysis mixture with a suitable acylating compound and use of the compounds of formula (I) to produce .alpha.-N-acyltryptophane.

    摘要翻译： 本发明涉及式（I）的N-酰基谷氨酸-γ-甲醛的环状缩醛，其中A是未取代的具有2至3个碳原子的亚烷基或这样的被1至2个取代的亚烷基 甲基，R是甲基，甲氧基，苯基或苄氧基，并且通过使其中A定义如上所述的通式（IMAGE）（II）的化合物的反应制备式（I）化合物的方法 用氰化氢或氰化物离子供给化合物，氨或铵离子供给化合物和二氧化碳或碳酸根离子供给化合物进行碱性水解，得到的反应混合物与水解混合物与合适的酰化化合物反应，并使用 式（I）的化合物以产生α-N-酰基色氨酸。

    Process for the production of peptides
    2.
    发明授权
    Process for the production of peptides 失效
    生产肽的方法

    公开(公告)号：US4374062A

    公开(公告)日：1983-02-15

    申请号：US311454

    申请日：1981-10-14

    申请人： Axel Kleemann ,  Jurgen Martens ,  Marc Samson

    发明人： Axel Kleemann ,  Jurgen Martens ,  Marc Samson

    IPC分类号： C07K1/00 ,  B01J31/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/18 ,  C07K1/02 ,  C07K1/113 ,  C07K5/06 ,  C07C103/52

    CPC分类号： C07K1/023

    摘要： There are produced peptides by asymmetrical hydrogenation of dehydropeptides of the general formula ##STR1## in which n is a whole number from 1 to 4, R.sub.1 and R.sub.2 are the same or different, and are hydrogen, a straight or branched chain alkyl group with 1 to 10 carbon atoms, or such a group substituted with a carboxyl group, a phenyl group which is unsubstituted or substituted in the 3 or 4 position or in both the 3 and 4 positions by a hydroxyl, alkoxy, or acyloxy group or an indolyl group which is unsubstituted or substituted in the 6 position by fluorine or chlorine or an indolyl group substituted by a methyl group. R.sub.3 is hydrogen, an alkali metal, or a lower alkyl group with 1 to 4 carbon atoms, R.sub.4 is hydrogen, an acetyl group or a chloroacetyl group and R.sub.5 is hydrogen or a straight or branched chain alkyl group having 1 to 4 carbon atoms with the proviso that when n is 2, 3, or 4, the individual groups R.sub.5 are the same or different, in the presence of chiral rhodium-complexes.

    摘要翻译： 通过非对称氢化产生通式为“IMAGE”的脱氢肽的肽，其中n为1至4的整数，R 1和R 2相同或不同，为氢，具有1个直链或支链烷基的直链或支链烷基 或被羧基取代的基团，未被取代或在3或4位或3或4位被羟基，烷氧基或酰氧基或吲哚基取代的苯基 其未被取代或在6位被氟或氯取代或被甲基取代的吲哚基。 R3是氢，碱金属或具有1至4个碳原子的低级烷基，R4是氢，乙酰基或氯乙酰基，R5是氢或具有1-4个碳原子的直链或支链烷基， 条件是当n为2,3或4时，在手性铑配合物的存在下，各基团R 5相同或不同。

    Disodium salt of trimercapto-s-triazine hexahydrate, and method of its preparation
    3.
    发明授权
    Disodium salt of trimercapto-s-triazine hexahydrate, and method of its preparation 失效
    三嗪硫青铜盐酸盐及其制备方法

    公开(公告)号：US5075444A

    公开(公告)日：1991-12-24

    申请号：US569139

    申请日：1990-08-17

    申请人： Klaus Hentschel ,  Marc Samson ,  Marcel Vingerhoets ,  Karl-Ludwig Weber

    发明人： Klaus Hentschel ,  Marc Samson ,  Marcel Vingerhoets ,  Karl-Ludwig Weber

    IPC分类号： C02F1/52 ,  C02F1/62 ,  C07D251/38

    CPC分类号： C02F1/5272 ,  C07D251/38

    摘要： The disodium salt of trimercapto-s-triazine hexahydrate (TMT-Na.sub.2.6H.sub.2 O) which has a considerably higher water solubility than previously known TMT sodium salts. It is used for separating heavy metals from aqueous phase, especially from waste water.TMT-Na.sub.2.6H.sub.2 O is prepared by reacting TMT-Na.sub.3 .9H.sub.2 O, available from cyanuric chloride, with trimercapto-s-triazine (TMT-Ha.sub.3) in a molar ratio of 2-2.1 to 1 in aqueous medium with subsequent crystallization of the TMT-Na.sub.2 .6H.sub.2 O.

    摘要翻译： 三水合三钙六水合物的二钠盐（TMT-Na2.6H2O）具有比先前已知的TMT钠盐显着更高的水溶性。 用于从水相中分离重金属，特别是废水。 TMT-Na2.6H2O是通过在水性介质中使得得自氰尿酰氯的TMT-Na 3·9H 2 O与三聚巯基-s-三嗪（TMT-Ha 3）的摩尔比为2-2.1〜1，随后TMT的结晶 -Na2.6H2O。

    Process for preparation of 2-vinylpyridine from acetylene and acrylonitrile
    6.
    发明授权
    Process for preparation of 2-vinylpyridine from acetylene and acrylonitrile 失效
    从乙炔和丙烯腈制备2-乙烯基吡啶的方法

    公开(公告)号：US4267329A

    公开(公告)日：1981-05-12

    申请号：US155803

    申请日：1980-06-02

    申请人： Helmut Bonnemann ,  Marc Samson

    发明人： Helmut Bonnemann ,  Marc Samson

    IPC分类号： C07D213/12 ,  B01J31/00 ,  C07B61/00 ,  C07D213/08 ,  C07D213/22 ,  C07F15/06 ,  C07C13/15 ,  C07C13/263

    CPC分类号： C07D213/08 ,  C07F15/06

    摘要： A process is described for the catalytic, selective preparation of 2-vinylpyridine from acetylene and acrylonitrile using a cyclopentadienylcobalt catalyst or .pi.-allylcobalt catalyst at elevated temperature in an inert solvent, wherein the acrylonitrile concentration is up to 2 mols/liter and the reaction is carried out at a temperature over 140.degree. C. and up to 180.degree. C., the reaction time being not more than 50 minutes.

    摘要翻译： 描述了一种用于在惰性溶剂中在高温下使用环戊二烯基钴催化剂或异戊醇钴催化剂从乙炔和丙烯腈催化选择性制备2-乙烯基吡啶的方法，其中丙烯腈浓度高达2摩尔/升，反应是 在140℃以上至180℃的温度下进行，反应时间不超过50分钟。

    Cyclic acetals of glutamic acid-.gamma.-semialdehyde, process for their production and use
    10.
    发明授权
    Cyclic acetals of glutamic acid-.gamma.-semialdehyde, process for their production and use 失效
    谷氨酸-γ-甲醛的环状缩醛，其生产和使用过程

    公开(公告)号：US4376864A

    公开(公告)日：1983-03-15

    申请号：US320131

    申请日：1981-11-10

    申请人： Karlheinz Drauz ,  Axel Kleemann ,  Marc Samson

    发明人： Karlheinz Drauz ,  Axel Kleemann ,  Marc Samson

    IPC分类号： C07D207/16 ,  C07D317/30 ,  C07D319/06 ,  C07D405/06

    CPC分类号： C07D207/16 ,  C07D317/30 ,  C07D319/06

    摘要： The invention is directed to cyclic acetals of glutamic acid-.gamma.-semialdehyde of the formula ##STR1## in which A is an unsubstituted alkylene group having 2 to 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups and to a method of producing a compound of formula (I) by reaction of a compound of the general formula ##STR2## in which A is as defined above with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and basic hydrolysis of the reaction mixture obtained and to using the compound of formula (I) to produce D,L-proline.

    摘要翻译： 本发明涉及式（I）的谷氨酸-γ-甲醛的环状缩醛，其中A为未取代的具有2至3个碳原子的亚烷基或亚烷基被1至2个甲基取代， 涉及制备式（I）化合物的方法，其中通式为其中A定义如上所定义的化合物与氰化氢或氰化物离子供应化合物反应，提供氨或铵离子 化合物和二氧化碳或碳酸根离子供应化合物和所得反应混合物的碱性水解和使用式（I）化合物产生D，L-脯氨酸。