公开(公告)号：US4376864A

公开(公告)日：1983-03-15

申请号：US320131

申请日：1981-11-10

申请人： Karlheinz Drauz ,  Axel Kleemann ,  Marc Samson

发明人： Karlheinz Drauz ,  Axel Kleemann ,  Marc Samson

IPC分类号： C07D207/16 ,  C07D317/30 ,  C07D319/06 ,  C07D405/06

CPC分类号： C07D207/16 ,  C07D317/30 ,  C07D319/06

摘要： The invention is directed to cyclic acetals of glutamic acid-.gamma.-semialdehyde of the formula ##STR1## in which A is an unsubstituted alkylene group having 2 to 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups and to a method of producing a compound of formula (I) by reaction of a compound of the general formula ##STR2## in which A is as defined above with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and basic hydrolysis of the reaction mixture obtained and to using the compound of formula (I) to produce D,L-proline.

摘要翻译： 本发明涉及式（I）的谷氨酸-γ-甲醛的环状缩醛，其中A为未取代的具有2至3个碳原子的亚烷基或亚烷基被1至2个甲基取代， 涉及制备式（I）化合物的方法，其中通式为其中A定义如上所定义的化合物与氰化氢或氰化物离子供应化合物反应，提供氨或铵离子 化合物和二氧化碳或碳酸根离子供应化合物和所得反应混合物的碱性水解和使用式（I）化合物产生D，L-脯氨酸。

公开(公告)号：US4424370A

公开(公告)日：1984-01-03

申请号：US320129

申请日：1981-11-10

申请人： Axel Kleemann ,  Marc Samson

发明人： Axel Kleemann ,  Marc Samson

IPC分类号： C07D209/20 ,  C07D317/30 ,  C07D319/06 ,  C07D405/06

CPC分类号： C07D209/20 ,  C07D317/30 ,  C07D319/06

摘要： The invention is directed to a cyclic acetal of N-acylglutamic acid-.gamma.-semialdehyde of the formula ##STR1## in which A is an unsubstituted alkylene group having 2 to 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups and R is a methyl, methoxy, phenyl, or benzyloxy group and to a method of producing a compound of formula (I) by reaction of a compound of the general formula ##STR2## in which A is as defined above, with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and basic hydrolysis of the reaction mixture obtained and reaction of the hydrolysis mixture with a suitable acylating compound and use of the compounds of formula (I) to produce .alpha.-N-acyltryptophane.

摘要翻译： 本发明涉及式（I）的N-酰基谷氨酸-γ-甲醛的环状缩醛，其中A是未取代的具有2至3个碳原子的亚烷基或这样的被1至2个取代的亚烷基 甲基，R是甲基，甲氧基，苯基或苄氧基，并且通过使其中A定义如上所述的通式（IMAGE）（II）的化合物的反应制备式（I）化合物的方法 用氰化氢或氰化物离子供给化合物，氨或铵离子供给化合物和二氧化碳或碳酸根离子供给化合物进行碱性水解，得到的反应混合物与水解混合物与合适的酰化化合物反应，并使用 式（I）的化合物以产生α-N-酰基色氨酸。

公开(公告)号：US4374062A

公开(公告)日：1983-02-15

申请号：US311454

申请日：1981-10-14

申请人： Axel Kleemann ,  Jurgen Martens ,  Marc Samson

发明人： Axel Kleemann ,  Jurgen Martens ,  Marc Samson

IPC分类号： C07K1/00 ,  B01J31/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C231/18 ,  C07K1/02 ,  C07K1/113 ,  C07K5/06 ,  C07C103/52

CPC分类号： C07K1/023

摘要： There are produced peptides by asymmetrical hydrogenation of dehydropeptides of the general formula ##STR1## in which n is a whole number from 1 to 4, R.sub.1 and R.sub.2 are the same or different, and are hydrogen, a straight or branched chain alkyl group with 1 to 10 carbon atoms, or such a group substituted with a carboxyl group, a phenyl group which is unsubstituted or substituted in the 3 or 4 position or in both the 3 and 4 positions by a hydroxyl, alkoxy, or acyloxy group or an indolyl group which is unsubstituted or substituted in the 6 position by fluorine or chlorine or an indolyl group substituted by a methyl group. R.sub.3 is hydrogen, an alkali metal, or a lower alkyl group with 1 to 4 carbon atoms, R.sub.4 is hydrogen, an acetyl group or a chloroacetyl group and R.sub.5 is hydrogen or a straight or branched chain alkyl group having 1 to 4 carbon atoms with the proviso that when n is 2, 3, or 4, the individual groups R.sub.5 are the same or different, in the presence of chiral rhodium-complexes.

摘要翻译： 通过非对称氢化产生通式为“IMAGE”的脱氢肽的肽，其中n为1至4的整数，R 1和R 2相同或不同，为氢，具有1个直链或支链烷基的直链或支链烷基 或被羧基取代的基团，未被取代或在3或4位或3或4位被羟基，烷氧基或酰氧基或吲哚基取代的苯基 其未被取代或在6位被氟或氯取代或被甲基取代的吲哚基。 R3是氢，碱金属或具有1至4个碳原子的低级烷基，R4是氢，乙酰基或氯乙酰基，R5是氢或具有1-4个碳原子的直链或支链烷基， 条件是当n为2,3或4时，在手性铑配合物的存在下，各基团R 5相同或不同。

公开(公告)号：US4374995A

公开(公告)日：1983-02-22

申请号：US320128

申请日：1981-11-10

申请人： Axel Kleemann ,  Marc Samson

发明人： Axel Kleemann ,  Marc Samson

IPC分类号： C07D403/06 ,  C07D209/20 ,  C07D233/76 ,  C07D233/30

CPC分类号： C07D209/20

摘要： Tryptophane hydantoin is prepared by(a) reacting a compound of the general formula ##STR1## where A is an alkylene group having 2 or 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups in aqueous or aqueous alcoholic solution with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and(b) reacting the reaction mixture obtained with phenyl hydrazine at a pH between 0.1 and 4.

摘要翻译： 色氨酸乙内酰脲通过以下方法制备：（a）使具有2或3个碳原子的亚烷基或其中1至2个甲基取代的亚烷基的通式为（IMA）的化合物（I）与含水或含水醇 用氰化氢或氰化物离子供给化合物，氨或铵离子供给化合物和二氧化碳或碳酸根离子供给化合物的溶液，和（b）使得到的反应混合物与苯肼在0.1至4的pH下反应。

公开(公告)号：US4342874A

公开(公告)日：1982-08-03

申请号：US320130

申请日：1981-11-10

申请人： Axel Kleemann ,  Marc Samson

发明人： Axel Kleemann ,  Marc Samson

IPC分类号： C07D405/06 ,  C07D209/20

CPC分类号： C07D209/20

摘要： The invention is directed to 2-[2'-(hydanto-5-yl)-ethyl]-5,5-dimethyl-1,3-dioxane of the formula ##STR1## its production by reaction of 2-(2'-formylethyl)-5,5-dimethyl-1,3-dioxane with hydrogen cyanide or a cyanide ion supplying compound, ammonia, or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound in aqueous alcoholic solution and its use for the production of tryptophane-hydantoin.

摘要翻译： 本发明涉及式（I）的2- [2' - （乙烷基-5-基） - 乙基] -5,5-二甲基-1,3-二恶烷，其通过2-（ 2'-甲酰基乙基）-5,5-二甲基-1,3-二恶烷与氰化氢或氰化物离子供应化合物，氨或铵离子供应化合物和二氧化碳或碳酸根离子供应化合物在含水醇溶液中 用于生产色氨酸 - 乙内酰脲。

公开(公告)号：US07316780B1

公开(公告)日：2008-01-08

申请号：US09890355

申请日：2000-01-31

申请人： Thomas J. Fendya ,  Mark F. Hurwitz ,  John D. Miller ,  Stephen A. Geibel ,  Marc Samson

发明人： Thomas J. Fendya ,  Mark F. Hurwitz ,  John D. Miller ,  Stephen A. Geibel ,  Marc Samson

IPC分类号： B01D39/20 ,  B01D39/00

CPC分类号： B01D61/12 ,  A23C9/1422 ,  B01D61/22 ,  B01D63/066 ,  B01D63/082 ,  B01D63/084 ,  B01D63/10 ,  B01D65/08 ,  B01D2311/14 ,  B01D2311/16 ,  B01D2315/10 ,  B01D2321/2008

摘要： Separation device comprising a feed channel including a shear region, permeate passage(s) extending perpendicular to the direction of the feed flow and a porous medium positioned between the shear region of the feed channel and the permeate passage(s). Separation process comprising generating a shear layer in a feed fluid and passing permeate into the permeate passage(s).

摘要翻译： 分离装置包括进料通道，该进料通道包括剪切区域，垂直于进料流动方向延伸的渗透通道和位于进料通道的剪切区域和渗透通道之间的多孔介质。 分离方法包括在进料流体中产生剪切层并将渗透物渗透到渗透通道中。

公开(公告)号：US06835574B2

公开(公告)日：2004-12-28

申请号：US09777364

申请日：2001-02-05

申请人： Andy C. Neilson ,  Michael R. Sweeney ,  James D. Orrell, III ,  Michael W. Oster ,  John M. Hopkins ,  Marc Samson

发明人： Andy C. Neilson ,  Michael R. Sweeney ,  James D. Orrell, III ,  Michael W. Oster ,  John M. Hopkins ,  Marc Samson

IPC分类号： G01N2101

CPC分类号： G01N25/72 ,  G01N25/482 ,  G01N25/4846

摘要： Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

公开(公告)号：US5258515A

公开(公告)日：1993-11-02

申请号：US932745

申请日：1992-08-25

申请人： Klaus Hentschel ,  Marc Samson ,  Marcel Vingerhoets ,  Karl-Ludwig Weber

发明人： Klaus Hentschel ,  Marc Samson ,  Marcel Vingerhoets ,  Karl-Ludwig Weber

IPC分类号： C07D251/38

CPC分类号： C07D251/38

摘要： The invention relates to aqueous solutions of sodium salts of trimercapto-s-triazine whose molar saturation concentration at 0.degree. C. to 40.degree. C. is above the saturation concentration of trimercapto-s-triazine trisodium salt (TMT-Na.sub.3). More than two but less than three hydrogen atoms of the trimercapto-s-triazine are replaced by sodium ions. The solutions preferably contain trimercapto-s-triazine disodium salt (TMT-Na.sub.2) in addition to a little TMT-Na.sub.3. Surprisingly, the water solubility of TMT-Na.sub.2 is greater than that of TMT-Na.sub.3. The solutions represent a suitable supply form for the active substance trimercapto-s-triazine (TMT-H.sub.3) used in the separation of heavy metals The preparation takes place by means of reacting TMT-Na.sub.3 with TMT-H.sub.3 in a molar ratio of 1:greater than 0-less than 0.5, especially 1:0.1 to 1:

摘要翻译： 本发明涉及三聚巯基三嗪的钠盐水溶液，其摩尔饱和浓度在0℃至40℃高于三巯基-s-三嗪三钠盐（TMT-Na 3）的饱和浓度。 三聚巯基-s-三嗪的多于两个但少于三个的氢原子被钠离子代替。 除了少量TMT-Na3之外，溶液优选含有三巯基-s-三嗪二钠盐（TMT-Na2）。 令人惊讶的是，TMT-Na2的水溶性大于TMT-Na3的水溶性。 该溶液代表用于分离重金属的活性物质三巯基-s-三嗪（TMT-H3）的合适供应形式。该制备通过使TMT-Na 3与TMT-H3以摩尔比1： 大于0-小于0.5，特别是在水溶液中为1：0.1至1：<0.5。

公开(公告)号：US5075444A

公开(公告)日：1991-12-24

申请号：US569139

申请日：1990-08-17

申请人： Klaus Hentschel ,  Marc Samson ,  Marcel Vingerhoets ,  Karl-Ludwig Weber

发明人： Klaus Hentschel ,  Marc Samson ,  Marcel Vingerhoets ,  Karl-Ludwig Weber

IPC分类号： C02F1/52 ,  C02F1/62 ,  C07D251/38

CPC分类号： C02F1/5272 ,  C07D251/38

摘要： The disodium salt of trimercapto-s-triazine hexahydrate (TMT-Na.sub.2.6H.sub.2 O) which has a considerably higher water solubility than previously known TMT sodium salts. It is used for separating heavy metals from aqueous phase, especially from waste water.TMT-Na.sub.2.6H.sub.2 O is prepared by reacting TMT-Na.sub.3 .9H.sub.2 O, available from cyanuric chloride, with trimercapto-s-triazine (TMT-Ha.sub.3) in a molar ratio of 2-2.1 to 1 in aqueous medium with subsequent crystallization of the TMT-Na.sub.2 .6H.sub.2 O.

摘要翻译： 三水合三钙六水合物的二钠盐（TMT-Na2.6H2O）具有比先前已知的TMT钠盐显着更高的水溶性。 用于从水相中分离重金属，特别是废水。 TMT-Na2.6H2O是通过在水性介质中使得得自氰尿酰氯的TMT-Na 3·9H 2 O与三聚巯基-s-三嗪（TMT-Ha 3）的摩尔比为2-2.1〜1，随后TMT的结晶 -Na2.6H2O。

公开(公告)号：US4675451A

公开(公告)日：1987-06-23

申请号：US828488

申请日：1986-02-12

申请人： Juan Andrade ,  Guenter Prescher ,  Marc Samson

发明人： Juan Andrade ,  Guenter Prescher ,  Marc Samson

IPC分类号： C07C47/12 ,  B01J31/00 ,  B01J31/24 ,  C07B61/00 ,  C07C45/00 ,  C07C45/42 ,  C07C45/49 ,  C07C45/50 ,  C07C45/51 ,  C07C67/00

CPC分类号： C07C45/49 ,  C07C45/515

摘要： A process is disclosed for the preparation of 2-alkyl-1,4-butanedial by hydroformylation of acetals of a 2-alkyl-substituted-1-propenal in the presence of a complex rhodium catalyst. The 3-alkyl-4,4-dialkoxybutanal obtained in this manner is separated and hydrolyzed to the desired compound.

摘要翻译： 公开了在复合铑催化剂存在下通过2-烷基取代的1-丙烯醛的缩醛的加氢甲酰基化制备2-烷基-1,4-丁二醛的方法。 以这种方式获得的3-烷基-4,4-二烷氧基丁醛被分离并水解成所需化合物。