公开(公告)号：US20070148224A1

公开(公告)日：2007-06-28

申请号：US11496151

申请日：2006-07-31

Applicant: Peter Ladislaus Dorogi ,  David Bruce Vasily ,  John Patrick McCook

Inventor： Peter Ladislaus Dorogi ,  David Bruce Vasily ,  John Patrick McCook

IPC: A61K9/127 ,  A61K31/555

CPC classification number: A61K8/19 ,  A61K8/494 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/127 ,  A61K31/555 ,  A61K45/06 ,  A61K47/10 ,  A61K47/32 ,  A61K2800/58 ,  A61Q19/008 ,  A61K2300/00

Abstract: This invention discloses compositions and method for treating various types of skin disorders, based on topical cutaneous delivery of copper chemically bound with botanical pigments. Sodium-copper-chlorophyllin is used as an example, showing benefits in the treatment of rosacea, acne, oily skin, enlarged pores, and in relieving skin inflammation. Benefits are also disclosed in treatment of environmentally caused premature skin aging, via reductions in fine facial lines and wrinkles, increased tensile strength of the skin, and increased protection against sunlight via increased production of melanin. Therapeutic outcomes are improved when the copper-pigment complex is enclosed within submicron liposomes.

Abstract translation: 本发明公开了基于与植物色素化学结合的铜的局部皮肤递送来治疗各种类型的皮肤病症的组合物和方法。 以铜 - 叶绿素钠为例，在治疗红斑痤疮，痤疮，油性皮肤，扩大的毛孔和减轻皮肤炎症方面具有优势。 通过减少细小的面部线条和皱纹，增加皮肤的拉伸强度，以及通过增加黑色素的产生来增加对日光的保护，也会公开治疗环境造成的皮肤老化的好处。 当铜 - 颜料复合物封闭在亚微米脂质体内时，治疗结果得到改善。

公开(公告)号：US07233947B2

公开(公告)日：2007-06-19

申请号：US10444009

申请日：2003-05-22

Applicant: David Bruce Lomet

Inventor： David Bruce Lomet

IPC: G06F17/30

CPC classification number: G06F17/30551 ,  G06F17/30353 ,  Y10S707/99938 ,  Y10S707/99939

Abstract: A method of assigning transaction timestamps for use with a database that includes temporal data and may include non-temporal data. In the method, a lock is placed on a resource accessed by a first transaction to prevent conflicts with concurrently executing transactions. An access record of the lock mode and a timestamp of the first transaction is created for the resource accessed by the first transaction. The access record is accessed to determine whether a resource that a subsequent transaction accesses conflicts with the resource accessed by the first transaction. A timestamp lower bound or floor is identified for the subsequent transaction when the subsequent transaction accesses a resource that conflicts with the resource access of the first transaction. A timestamp is assigned to the subsequent transaction that is greater than the lower bound. The access record of a lock mode and a transaction timestamp may be created each time a resource is accessed, may be created for resources accessed after a request for CURRENT TIME is made, and/or may be made for resources accessed after an end time of a time interval defined by a request for CURRENT TIME.

Abstract translation: 分配用于包括时间数据的数据库的事务时间戳的方法，并且可以包括非时间数据。 在该方法中，锁被放置在由第一事务访问的资源上以防止与并发执行事务的冲突。 为第一个事务访问的资源创建锁定模式的访问记录和第一个事务的时间戳。 访问访问记录以确定后续事务访问的资源是否与第一个事务访问的资源冲突。 当后续事务访问与第一个事务的资源访问冲突的资源时，为后续事务识别时间戳下限或下限。 时间戳被分配给大于下限的后续事务。 可以在每次访问资源时创建锁定模式和事务时间戳的访问记录，可以在进行CURRENT TIME的请求之后创建用于访问的资源，并且/或可以为在 由CURRENT TIME的请求定义的时间间隔。

公开(公告)号：US07229984B2

公开(公告)日：2007-06-12

申请号：US11298245

申请日：2005-12-09

Applicant: Ralph New Harris, III ,  James M. Kress ,  David Bruce Repke ,  Russell Stephen Stabler

Inventor： Ralph New Harris, III ,  James M. Kress ,  David Bruce Repke ,  Russell Stephen Stabler

IPC: C07D267/02 ,  C07D281/02 ,  C07D243/10 ,  C07D498/00 ,  A61K31/55

CPC classification number: C07D413/06 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D413/04

Abstract: Compounds of the Formula I: wherein m, n, k, A, X, Y, Z, Ar, R1, R2, R3, and R4 are as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also provided are compositions comprising, methods of using, and methods of making the subject compounds.

Abstract translation: 式I化合物：其中m，n，k，A，X，Y，Z，Ar，R 1，R 2，R 3， SUP>和R 4如本文所定义。 该化合物可用作5-HT 6受体拮抗剂。 还提供了包含，使用方法和制备本发明化合物的方法的组合物。

公开(公告)号：US07214518B2

公开(公告)日：2007-05-08

申请号：US10491854

申请日：2002-10-08

Applicant: Malcom Anderson ,  Nicholas John Keen ,  Andrew David Bruce Pannifer ,  Richard Alexander Pauptit ,  Sian Rowsell

Inventor： Malcom Anderson ,  Nicholas John Keen ,  Andrew David Bruce Pannifer ,  Richard Alexander Pauptit ,  Sian Rowsell

IPC: C12N9/00

CPC classification number: C12N9/1205 ,  Y02A90/24 ,  Y02A90/26

Abstract: The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors. These modulators may be used to treat diseases of cell proliferation, e.g. cancer.

Abstract translation: 本发明提供了对应于极光激酶催化结构域的多肽的结晶形式。 活性位点ATP结合口袋由其氨基酸残基及其原子坐标定义。 该结构可用于选择或设计Aurora激酶的化学​​调节剂，特别是Aurora抑制剂。 这些调节剂可用于治疗细胞增殖的疾病，例如， 癌症。

公开(公告)号：US20070085696A1

公开(公告)日：2007-04-19

申请号：US11252905

申请日：2005-10-18

Applicant: Wai-Ieung Ha ,  Kairy Kei Lei ,  David Bruce Stevens

Inventor： Wai-Ieung Ha ,  Kairy Kei Lei ,  David Bruce Stevens

IPC: G05B19/02

CPC classification number: H04B3/54 ,  H04B2203/5408 ,  H04B2203/542 ,  H04B2203/5441

Abstract: The present invention supports pairing a transmitter and a receiver that use the same power line and power module. The transmitter associates an identification number with a command message so that a receiver can ascertain that a command message is intended for the receiver. The transmitter uses the time from the power up to the first zero crossing of the AC signal to generate a matching seed for both transmitter and receiver. The transmitter generates an identification number by incrementing a counter each incremental time interval between power up and the occurrence of the first zero crossing of the AC signal and sends the generated identification number to the paired receiver after power up but before a predetermined time interval. The receiver stores the generated identification number and compares the stored identification number with a received identification number that is received in a subsequent command message.

Abstract translation: 本发明支持使用相同电力线和功率模块的发射机和接收机的配对。 发射机将识别号码与命令消息相关联，使得接收机可以确定命令消息是针对接收机的。 发射机使用从交流信号的上电到第一过零点的时间来为发射机和接收机生成匹配的种子。 发射机通过在上电和AC信号的第一过零点的出现之间递增计数器来产生识别号码，并且在上电之后但在预定的时间间隔之前将生成的识别号码发送到配对的接收机。 接收器存储所生成的标识号，并将存储的标识号与在随后的命令消息中接收到的接收的标识号进行比较。

公开(公告)号：US07200656B1

公开(公告)日：2007-04-03

申请号：US10245089

申请日：2002-09-17

Applicant: David Bruce Cousins

Inventor： David Bruce Cousins

IPC: G06F15/173

CPC classification number: H04L43/045 ,  H04L43/0894

Abstract: A method of processing a communication signal may include computing a number of periodograms from the signal. Each of the periodograms may be generated from a portion of the signal. The number of periodograms may be combined in time sequence to form a spectrogram [510] containing the periodograms. A cepstrogram [520–540] may be generated by performing cepstrum processing on the spectrogram. The cepstrogram may be used to classify [330] the type of communication that produced the signal.

Abstract translation: 处理通信信号的方法可以包括从信号计算周期图的数量。 每个周期图可以从信号的一部分产生。 周期图的数量可以按时间顺序组合以形成包含周期图的频谱图[510]。 可以通过在光谱图上执行倒频谱处理来生成蜂巢图[520-540]。 可以使用cepstrogram来分类[330]产生信号的通信类型。

公开(公告)号：US07181195B2

公开(公告)日：2007-02-20

申请号：US10076335

申请日：2002-02-14

Applicant: Yvonne Watters Booth ,  David Bruce Kumhyr

Inventor： Yvonne Watters Booth ,  David Bruce Kumhyr

IPC: H04M1/66

CPC classification number: H04W12/12 ,  G06F21/88

Abstract: When a piece of network equipment is determined to be stolen or missing, a hardware tracing tool mounted within the network detects the distinctive hardware fingerprints of the missing hardware within Internet traffic and extracts the device's IP address to trace the location of the missing equipment. As Internet messages or data packets cross through servers containing the tracing tool, the data packets are decompiled to retrieve unique identifier indicia (hardware fingerprints), such as a computer's MAC address, for example. The extracted fingerprints are then compared with fingerprints stored in a database of missing hardware using a hashing or mapping function, and the server system is alerted to a match. The IP address of the device transmitting the matching indicia is then extracted to determine the location of the missing or stolen network hardware. In this way, a method of tracing missing network hardware is provided that does not increase the cost of network equipment or unnecessarily effect network bandwidth.

Abstract translation: 当网络设备被确定为被盗或丢失时，安装在网络内的硬件跟踪工具会检测互联网流量中缺失的硬件的不同硬件指纹，并提取设备的IP地址以跟踪丢失设备的位置。 随着Internet消息或数据包跨越包含跟踪工具的服务器，数据包被反编译以检索例如计算机的MAC地址的唯一标识符标记（硬件指纹）。 然后将提取的指纹与使用散列或映射功能存储在丢失硬件的数据库中的指纹进行比较，并且提醒服务器系统进行匹配。 然后提取发送匹配标记的设备的IP地址，以确定丢失或被盗网络硬件的位置。 以这种方式，提供了一种跟踪丢失的网络硬件的方法，其不会增加网络设备的成本或不必要地影响网络带宽。

公开(公告)号：US07152222B2

公开(公告)日：2006-12-19

申请号：US10042108

申请日：2002-01-08

Applicant: David Bruce Kumhyr ,  Lorin Evan Ullmann ,  Keiichi Yamamoto

Inventor： David Bruce Kumhyr ,  Lorin Evan Ullmann ,  Keiichi Yamamoto

IPC: G06F9/44

CPC classification number: G06F9/454

Abstract: A method, a system, an apparatus, and a computer program product are presented for facilitating the customization, translation, or localization of messages, strings, or other program resources to be used by a locale-sensitive version of a Java™ program stored in a Java™ JAR file. After opening the JAR file, text strings within a resource bundle for a first locale can be determined through a particular process for inspecting the resource bundle. A resource bundle for a second locale containing translated versions of the text strings can be created through various means and then stored into the modified JAR file.

Abstract translation: 提供了一种方法，系统，装置和计算机程序产品，用于促进要由Java（TM）程序的区域设置敏感版本使用的消息，字符串或其他程序资源的定制，翻译或本地化 存储在Java（TM）JAR文件中。 打开JAR文件后，可以通过用于检查资源束的特定进程确定第一个区域设置的资源束中的文本字符串。 包含文本字符串的翻译版本的第二个区域的资源束可以通过各种方式创建，然后存储到修改的JAR文件中。

公开(公告)号：US07137108B1

公开(公告)日：2006-11-14

申请号：US09697446

申请日：2000-10-26

Applicant: David Bruce Kumhyr ,  Dae-Suk Chung

Inventor： David Bruce Kumhyr ,  Dae-Suk Chung

IPC: G06F9/45 ,  G06F15/00

CPC classification number: G06F8/425

Abstract: A method, computer program product and data processing system for identifying non-externalized strings that are not hard-coded. In one embodiment, a method comprises the step of scanning a code, e.g., Java, line by line until a pair of string delimiters is identified. Once a pair of string delimiters is identified, the method further comprises the step of determining whether the string within the pair of string delimiters identified is a path name to a resource file, e.g., resource bundle. If the string is a path name to the resource file, then the string is a non-externalized string that is not hard-coded. If the string is not a path name to the resource file, then the string may be identified as a possible hard-coded string.

Abstract translation: 一种用于识别非硬化编码的非外部字符串的方法，计算机程序产品和数据处理系统。 在一个实施例中，一种方法包括逐行扫描代码例如Java的步骤，直到识别出一对字符串分隔符。 一旦识别出一对字符串分隔符，则该方法还包括确定所标识的一对字符串分隔符内的字符串是否是资源文件（例如资源束）的路径名称的步骤。 如果字符串是资源文件的路径名，则该字符串是非硬编码的非外部化字符串。 如果字符串不是资源文件的路径名，则字符串可能被识别为可能的硬编码字符串。

公开(公告)号：US07094778B2

公开(公告)日：2006-08-22

申请号：US10685124

申请日：2003-10-14

Applicant: Charles Alois Dvorak ,  Lawrence Emerson Fisher ,  Keena Lynn Green ,  Ralph New Harris, III ,  Hans Maag ,  Anthony Prince ,  David Bruce Repke ,  Russell Stephen Stabler

Inventor： Charles Alois Dvorak ,  Lawrence Emerson Fisher ,  Keena Lynn Green ,  Ralph New Harris, III ,  Hans Maag ,  Anthony Prince ,  David Bruce Repke ,  Russell Stephen Stabler

IPC: A61K31/513 ,  C07D279/06 ,  C07D413/12 ,  C07D239/10 ,  C07D241/08

CPC classification number: C07D207/27 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  C07D211/76 ,  C07D223/10 ,  C07D225/02 ,  C07D239/10 ,  C07D241/08 ,  C07D243/04 ,  C07D243/08 ,  C07D265/10 ,  C07D267/06 ,  C07D267/10 ,  C07D267/22 ,  C07D279/06 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D411/12 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.