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    Multivalent immunoglobulin-based bioactive assemblies
    92.
    发明授权
    Multivalent immunoglobulin-based bioactive assemblies 有权
    基于多价免疫球蛋白的生物活性组件

    公开(公告)号：US07527787B2

    公开(公告)日：2009-05-05

    申请号：US11633729

    申请日：2006-12-05

    申请人： Chien-Hsing Chang ,  David M. Goldenberg ,  Edmund A. Rossi

    发明人： Chien-Hsing Chang ,  David M. Goldenberg ,  Edmund A. Rossi

    IPC分类号： C07K1/32 ,  C07K16/28 ,  C07K16/46 ,  C07K16/30 ,  A61K38/16

    CPC分类号： C07K16/468 ,  A61K47/6897 ,  A61K51/088 ,  B82Y5/00 ,  B82Y10/00 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/3007 ,  C07K16/3092 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/70

    摘要： The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a facile and general way to obtain stably tethered structures of virtually any functionality and/or binding specificity. The stably tethered structures may be administered to subjects for diagnostic and/or therapeutic use, for example for treatment of cancer or autoimmune disease. The stably tethered structures may bind to and/or be conjugated to a variety of known effectors, such as drugs, enzymes, radionuclides, therapeutic agents and/or diagnostic agents.

    摘要翻译： 本发明涉及可以具有多种功能和/或结合特异性的限定组合物的稳定的束缚结构的方法和组合物。 优选的实施方案涉及包含一种或多种IgG抗体片段并且可以是单特异性或双特异性的六聚体稳定的束缚结构。 所公开的方法和组合物提供了实现任何功能和/或结合特异性的稳定的束缚结构的简便和一般的方法。 稳定的束缚结构可以施用于受试者用于诊断和/或治疗用途，例如用于治疗癌症或自身免疫性疾病。 稳定的束缚结构可以结合到各种已知的效应物上，和/或与其结合，例如药物，酶，放射性核素，治疗剂和/或诊断剂。

    Stably tethered structures of defined compositions with multiple functions or binding specificities
    93.
    发明授权
    Stably tethered structures of defined compositions with multiple functions or binding specificities 有权
    具有多种功能或结合特异性的定义组合物的稳定的束缚结构

    公开(公告)号：US07521056B2

    公开(公告)日：2009-04-21

    申请号：US11391584

    申请日：2006-03-28

    申请人： Chien Hsing Chang ,  David M. Goldenberg ,  William J. McBride ,  Edmund A. Rossi

    发明人： Chien Hsing Chang ,  David M. Goldenberg ,  William J. McBride ,  Edmund A. Rossi

    IPC分类号： A61K38/01 ,  A61K38/19 ,  A61K38/21 ,  A61K39/395 ,  C07K14/52 ,  C07K14/535 ,  C07K14/405 ,  C07K14/56

    CPC分类号： C07K16/18 ,  A61K39/395 ,  A61K47/65 ,  A61K47/6853 ,  A61K51/088 ,  A61K51/1048 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K16/283 ,  C07K16/3007 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2319/00 ,  C07K2319/70

    摘要： The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.

    摘要翻译： 本发明涉及用于具有多种功能和/或结合特异性的限定组合物的稳定束缚结构的方法和组合物。 具体实施方案涉及稳定的包含第一单体的同二聚体的束缚结构，其包含连接到第一前体的二聚化和对接结构域，以及包含连接到第二前体的锚定结构域的第二单体。 第一和第二前体实际上可以是任何分子或结构，例如抗体，抗体片段，抗体类似物或模拟物，适体，结合肽，结合蛋白片段，蛋白质或其他分子的已知配体，酶，可检测标记或标签， 治疗剂，毒素，药物，细胞因子，白介素，干扰素，放射性同位素，蛋白质，肽，肽模拟物，多核苷酸，RNAi，寡糖，天然或合成聚合物质，纳米颗粒，量子点，有机或无机化合物等。 组合物提供了一种简单，易于纯化的方式来获得连接到任何单体化合物或任何三元化合物上的任何二元化合物。

    METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY AND DETECTION OF INFLAMMATORY AND IMMUNE-DYSREGULATORY DISEASE, INFECTIOUS DISEASE, PATHOLOGIC ANGIOGENESIS AND CANCER
    96.
    发明申请
    METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY AND DETECTION OF INFLAMMATORY AND IMMUNE-DYSREGULATORY DISEASE, INFECTIOUS DISEASE, PATHOLOGIC ANGIOGENESIS AND CANCER 有权
    免疫学方法和组合物，检测炎症和免疫缺陷性疾病，感染性疾病，病理性血管生成和癌症

    公开(公告)号：US20080241145A1

    公开(公告)日：2008-10-02

    申请号：US11929279

    申请日：2007-10-30

    申请人： David M. Goldenberg ,  Hans J. Hansen

    发明人： David M. Goldenberg ,  Hans J. Hansen

    IPC分类号： A61K39/395 ,  C07K16/18

    CPC分类号： A61K39/3955 ,  A61K31/513 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/4866 ,  A61K39/40 ,  A61K45/06 ,  A61K49/0002 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1203 ,  C07K16/24 ,  C07K16/241 ,  C07K16/248 ,  C07K16/2803 ,  C07K16/2896 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/734

    摘要： A multispecific antagonist is disclosed that reacts specifically with at least two different targets. The targets are (A) proinflammatory effectors of the innate immune system, (B) coagulation factors, (C) complement factors and complement regulatory proteins, and (D) targets specifically associated with an inflammatory or immune-dysregulatory disorder or with a pathologic angiogenesis or cancer, wherein this latter target is not (A), (B) or (C). At least one of the targets is (C), and when the multispecific antagonist comprises a single multispecific antibody, then CD74 is excluded as a target of said antagonist. When the multispecific antagonist comprises a combination of separate antibodies, combinations are excluded where one of said antibodies targets a B-cell antigen and the other antibody targets a T-cell, plasma cell, macrophage or inflammatory cytokine and combinations are also excluded where one of said antibodies targets CD20 and the other antibody targets C3b or CD40.

    摘要翻译： 公开了与至少两个不同靶物特异性反应的多特异性拮抗剂。 目标是（A）先天免疫系统的促炎效应物，（B）凝血因子，（C）补体因子和补体调节蛋白，以及（D）与炎症或免疫调节障碍或病理血管发生特异性相关的靶标 或癌症，其中后一靶标不是（A），（B）或（C）。 至少一个目标是（C），并且当多特异性拮抗剂包含单个多特异性抗体时，则排除CD74作为所述拮抗剂的靶标。 当多特异性拮抗剂包含单独的抗体的组合时，除了其中一种所述抗体靶向B细胞抗原并且另一种抗体靶向T细胞，浆细胞，巨噬细胞或炎性细胞因子的组合之外，并且组合也被排除在其中之一 所述抗体靶向CD20，其他抗体靶标为C3b或CD40。

    Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites
    99.
    发明申请
    Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites 审中-公开
    治疗剂的聚合载体和用于基于抗体靶向疾病部位的识别部分

    公开(公告)号：US20080171067A1

    公开(公告)日：2008-07-17

    申请号：US11961436

    申请日：2007-12-20

    申请人： Serengulam V. Govindan ,  Sung-Ju Moon ,  David M. Goldenberg ,  Chien-Hsing Chang

    发明人： Serengulam V. Govindan ,  Sung-Ju Moon ,  David M. Goldenberg ,  Chien-Hsing Chang

    IPC分类号： A61K47/48

    CPC分类号： B82Y5/00 ,  A61K47/556 ,  A61K47/61 ,  A61K47/6425 ,  A61K47/645 ,  A61K47/65 ,  A61K47/665 ,  A61K47/6835 ,  A61K47/6897 ,  A61K47/6951

    摘要： The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.

    摘要翻译： 本发明涉及用于将治疗剂递送至靶细胞，组织或生物体的方法和组合物。 在优选的实施方案中，治疗剂以治疗负荷聚合物的形式递送，其可以包含许多拷贝的一种或多种治疗剂。 在更优选的实施方案中，聚合物可以与含有一种或多种半抗原如HSG的肽部分缀合。 药剂 - 聚合物 - 肽复合物可以通过例如利用双特异性或多特异性抗体或片段的预靶向技术递送至靶细胞，所述双特异性或多特异性抗体或片段具有识别半抗原的至少一个结合臂和至少一个结合的结合臂 具体涉及疾病或病原体相关抗原，例如肿瘤相关抗原。 提供了合成和使用这种治疗负载型聚合物及其共轭物的方法。