公开(公告)号：US20230046749A1

公开(公告)日：2023-02-16

申请号：US17823685

申请日：2022-08-31

Applicant: OSAKA UNIVERSITY

Inventor： Hodaka FUJII ,  Toshitsugu FUJITA

IPC: C12Q1/6806 ,  C12N15/10 ,  G01N33/53

Abstract: A method comprising (A) fragmenting genomic DNA in a state where the interaction of the genomic DNA and molecules interacting therewith is maintained, and (B) bringing genomic DNA into contact with an exogenous molecule capable of binding to a specific endogenous DNA sequence in the genomic DNA. According to the method, with the use of an endogenous DNA sequence present inside or in the vicinity of a target genomic region in cells to be analyzed, any genomic region can be specifically isolated in a state where the interaction of the genomic region and molecules interacting therewith is maintained, without the need of inserting a recognition sequence of an exogenous DNA-binding molecule into the vicinity of the target genomic region in the cells to be analyzed.

公开(公告)号：US20230035766A1

公开(公告)日：2023-02-02

申请号：US17788269

申请日：2020-12-21

Applicant: Nihon Kohden Corporation ,  Osaka University

Inventor： Hodaka Makino ,  Hirotsugu Kubo ,  Masahiro Kinooka

IPC: C12M1/34 ,  C12M1/36

Abstract: The presently disclosed subject matter provides a cell culture evaluation system including a measurement unit, a first storage unit, a second storage unit, an evaluation unit and an output unit, wherein: the measurement unit includes a sensor that acquires evaluation target data about motion or a state of a culture tool; the first storage unit stores the evaluation target data; the second storage unit stores reference data; the evaluation unit compares the evaluation target data with the reference data so as to evaluate an execution state of a cell culture process; and the output unit outputs an evaluation result created by the evaluation unit.

公开(公告)号：US20230029594A1

公开(公告)日：2023-02-02

申请号：US17788524

申请日：2020-12-23

Applicant: OSAKA UNIVERSITY ,  INNATE CELL THERAPY INC.

Inventor： Shizuo AKIRA ,  JOSE CALDEZ MATIAS ,  Nobuo SAKAGUCHI

IPC: C12Q1/02 ,  A61P1/16 ,  C12N15/113 ,  C07K16/40

Abstract: The present invention provides a body fat reducing agent comprising a Regnase-1 inhibitor as an active ingredient, and a method for screening for a substance capable of reducing body fat, the method comprising selecting a substance capable of inhibiting the expression of Regnase-1 or a substance capable of inhibiting the function of Regnase-1. The body fat reducing agent of the present invention is useful for improving metabolic syndrome, and for preventing and/or treating fatty liver disease, including nonalcoholic steatohepatitis (NASH). The screening method of the present invention can be used to identify a useful substance capable of reducing body fat.

公开(公告)号：US20230014662A1

公开(公告)日：2023-01-19

申请号：US17786372

申请日：2020-12-21

Applicant: OSAKA UNIVERSITY ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

Inventor： Masateru TANIGUCHI ,  Tomofumi TADA

IPC: G06N10/40

Abstract: Provided is a quantum computer which makes it possible to easily carry out quantum calculation. A quantum computer (10) includes electrodes (20) and (21), a molecule (22) that is entirely or partially provided between the electrodes (20) and (21), and a current sensor 13 that detects a tunneling current which flows between the electrodes (20) and (21) via the molecule (22). The molecule (22) works as a quantum circuit for carrying out quantum calculation.

公开(公告)号：US20230010572A1

公开(公告)日：2023-01-12

申请号：US17260185

申请日：2019-07-12

Applicant: THE UNIVERSITY OF TOKYO ,  OSAKA UNIVERSITY

Inventor： Takuro IDEGUCHI ,  Keiichiro TODA ,  Miu TAMAMITSU ,  Kazuki HASHIMOTO ,  Ryoichi HORISAKI

IPC: G06T5/50 ,  H04N5/225 ,  G01N21/3563 ,  G02B21/36

Abstract: Irradiation light in a visible light region is irradiated to a sample while switching irradiation of infrared light IR having a wavelength that corresponds to the infrared absorption spectrum of an observation target material included in the sample between a first state and a second state. A first image and a second image are generated based on the phase distribution, the intensity distribution, and the polarization direction distribution of the light including the irradiation light that has passed through the sample in synchronization with the switching of the infrared light IR irradiation between the first state and the second state. Subsequently, an output image is generated so as to represent one from among the position, size, and shape based on the difference and/or ratio with respect to the pixel values for each pixel between the first image and the second image.

公开(公告)号：US20230005390A1

公开(公告)日：2023-01-05

申请号：US17940319

申请日：2022-09-08

Applicant: OSAKA UNIVERSITY ,  JMC CORPORATION

Inventor： Keita OKAYAMA ,  Yasushi SAKATA ,  Daichi WATANABE ,  Makoto INADA

IPC: G09B23/28

Abstract: The present invention is a heart model that is used at the time of performing a simulation of an operation for installing a leadless pacemaker in the inner part or a simulation of a myocardial examination method of collecting myocardial tissue, and is formed by means of a material having elasticity. The heart model has a main body having a right atrium, a right ventricle, a left atrium, and a left ventricle in the inner part; an inferior vena cava provided in the main body and allowing insertion therethrough of a catheter holding a leadless pacemaker; and a holder detachably provided inside the main body and including a flexible part capable of locking a locking part of a leadless pacemaker.

公开(公告)号：US11532767B2

公开(公告)日：2022-12-20

申请号：US16970329

申请日：2019-02-15

Applicant: OSAKA UNIVERSITY ,  National University Corporation Tokai National Higher Education and Research System ,  NICHIA CORPORATION

Inventor： Susumu Kuwabata ,  Taro Uematsu ,  Kazutaka Wajima ,  Tsukasa Torimoto ,  Tatsuya Kameyama ,  Daisuke Oyamatsu

IPC: H01L33/26 ,  B82Y20/00 ,  B82Y40/00 ,  H01L33/00 ,  H01L33/50

Abstract: Provided is a method of producing semiconductor nanoparticles that exhibit a band-edge emission, and are superior in quantum yield. The method includes raising the temperature of a first mixture containing a silver (Ag) salt, a salt containing at least one of indium (In) and gallium (Ga), a solid compound that serves as a supply source of sulfur (S), and an organic solvent to a temperature in a range of from 125° C. to 175° C., and heat-treating, subsequent to the raising of the temperature, the first mixture at a temperature in a range of from 125° C. to 175° C. for three seconds or more to obtain a solution containing semiconductor nanoparticles, and decreasing the temperature of the solution containing semiconductor nanoparticles. The solid compound that serves as a supply source of S contains thiourea.

公开(公告)号：US11510980B2

公开(公告)日：2022-11-29

申请号：US16761027

申请日：2018-11-02

Applicant: VICTORIA LINK LTD ,  OSAKA UNIVERSITY

Inventor： Amy Jane Foster ,  Bridget Louise Stocker ,  Mattheus Simon Maria Timmer ,  Sho Yamasaki

IPC: A61P37/04 ,  C07H13/08 ,  A61K31/7024 ,  A61K39/39 ,  C07H15/18

Abstract: The invention relates to brartemicin analogues of Formula (IV) and their uses. These compounds are potent Mincle agonists and Th1-stimulating vaccine adjuvants.

公开(公告)号：US11501768B2

公开(公告)日：2022-11-15

申请号：US16490928

申请日：2018-01-26

Applicant: NIPPON TELEGRAPH AND TELEPHONE CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hiroaki Sugiyama ,  Hiromi Narimatsu ,  Yuichiro Yoshikawa ,  Hiroshi Ishiguro

IPC: G10L15/22 ,  G06F3/01 ,  G06F3/16 ,  G10L13/00

Abstract: It is an object of the present invention to promote a user's understanding or agreement, and to cause a dialogue to last long. A dialogue system 100 conducts a dialogue with a user 101. A humanoid robot 50-1 presents a first utterance which is a certain utterance. When the user 101 performs an action indicating that the user cannot understand the first utterance or it is predicted that the user performs an action indicating that the user cannot understand the first utterance or when the user does not perform any action indicating that the user can understand the first utterance, or it is predicted that the user will not perform any action indicating that the user can understand the first utterance, then the humanoid robot 50-1 presents a second utterance which is at least one utterance resulting from paraphrasing the contents of the first utterance.

公开(公告)号：US11492418B2

公开(公告)日：2022-11-08

申请号：US17276358

申请日：2019-10-08

Applicant: OSAKA UNIVERSITY ,  DKS CO. LTD.

Inventor： Toshiyuki Kida ,  Masahito Nishiura

IPC: C08B15/00

Abstract: Provided is a novel cyclic oligosaccharide derived from cellulose. The cyclic oligosaccharide is a cyclic oligosaccharide of Formula (1) having a β-1,4 glucosidic bond. In the formula, R represents a hydrogen atom or a substituent thereof, a plurality of the Rs may be identical or different, and n represents an integer of 0 to 3.