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公开(公告)号：US20200275687A1
公开(公告)日：2020-09-03
申请号：US16612069
申请日：2018-05-09
Applicant: Arizona Board of Regents on Behalf of the University of Arizona , Arizona Board of Regents on Behalf of Arizona State University
Inventor： Hanqing Jiang , Wenwen Xu , Haokai Yang , Wei Zeng , Hongbin Yu , Marvin J. Slepian
IPC: A23P20/10 , A61B5/00 , A23L29/294
Abstract: Edible electrical systems containing food and/or food-based materials that possess electrical characteristics comparable or substantially equal to those of conventional materials used traditional electronic circuits and configured to include at least one of a capacitor, resistor, inductor, microphone, RF filter, pH monitoring device to collect information representing a living biological tissue from inside a body. A set of materials for use in constructing such edible electrical systems and methods of using such systems for acquiring such information. Edible electrical systems may be configured to be implantable.
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公开(公告)号：US10697975B2
公开(公告)日：2020-06-30
申请号：US15630751
申请日：2017-06-22
Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services , Board of Regents of the University of Nebraska , University of Rochester , Arizona Board of Regents on Behalf of the University of Arizona , Universitat de Barcelona , Fundacio Clinic , Hospital Clinic de Barcelona , Julius-Maximilians-University of Wurzburg , British Columbia Cancer Agency Branch , Oslo University Hospital HF , Queen Mary and Westfield College, University of London
Inventor： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine S. Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa M. Rimsza , Thomas Miller , Thomas Grogan , Elias Campo Guerri , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emilio Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend B. Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC: G01N33/48 , G01N33/68 , G16B25/00 , C12Q1/6886 , G16B40/00
Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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93.发明授权公开(公告)号：US10585322B2
公开(公告)日：2020-03-10
申请号：US15304177
申请日：2015-04-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventor： Anna Llordés Gil , Delia J. Milliron , Gabriel LeBlanc , Yang Wang
IPC: B05D3/10 , G02F1/153 , C01G33/00 , G02F1/15 , B05D1/18 , G02F1/155 , C01G35/00 , C01G31/02 , G02F1/1516
Abstract: Described are electrochromic films produced by low temperature condensation of polyoxometalates and applications thereof. A method of producing an electrochromic film includes depositing a polyoxometalate (POM) solution on a substrate to form a POM film. The POM solution includes anionic POM clusters and counter ions, and may be doped with near-infrared plasmonic nanocrystals. The film is chemically cured using an acid to condense the POM clusters within the POM film. Another method of producing an electrochromic film includes electrochemical deposition and condensation of POM clusters.
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公开(公告)号：US10358439B2
公开(公告)日：2019-07-23
申请号：US15759884
申请日：2016-09-16
Applicant: Board of Regents, The University of Texas System , Board of Regents, The University of Texas System
Inventor： Waldemar Priebe , Liwei Guo , Arkadiusz Kazimierski , Izabela Fokt , Charles Conrad , Timothy Madden
IPC: C07C13/66 , C07D309/14 , C07D405/12 , C07D405/14 , C07H15/24 , C07H15/244 , A61P35/00
Abstract: Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.
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公开(公告)号：US10281476B2
公开(公告)日：2019-05-07
申请号：US14565811
申请日：2014-12-10
Inventor： Razvan L. Cornea , Donald M. Bers , David D. Thomas , Gregory D. Gillispie
Abstract: Provided herein are methods for identifying a compound that modulates a Ryanodine receptor (Ryr). Fluorescence resonance energy transfer between an FKBP bound to an RyR and fluorescent derivatives of RyR binding partners (e.g., calmodulin) or domain-peptide biosensors is used to provide a readout dependent on the RyR functional state. The methods permit measurement of RyR present in a permeabilized cell or in a purified membrane.
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Patent Agency Ranking
公开(公告)号：US20190070370A1
公开(公告)日：2019-03-07
申请号：US16179024
申请日：2018-11-02
Applicant: The Regents of the University of Colorado, a Body Corporate , Board of Regents for the University of Nebraska
Inventor： Mark A. Borden , Benjamin S. Terry
IPC: A61M13/00
Abstract: A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles. Through circulation of oxygen microbubbles through the body cavity, oxygen and carbon dioxide exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen-intake restricting injury and/or failure may be achieved through use of the invented system and methods.
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97.发明申请公开(公告)号：US20180280580A1
公开(公告)日：2018-10-04
申请号：US15765981
申请日：2016-10-07
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventor： Jeffrey S. SAKAMOTO , Dena SHAHRIARI , Mark H. TUSZYNSKI , Wendy CAMPANA , Yacov KOFFLER
CPC classification number: A61L27/56 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2430/32 , C08L67/04 , C08L89/06 , C08L89/00
Abstract: Tissue scaffolds for neural tissue growth have a plurality of microchannels disposed within a sheath. Each microchannel comprises a porous wall having a thickness of ≤about 100 μm that is formed from a biocompatible and biodegradable material comprising a polyester polymer. The polyester polymer may be polycaprolactone, poly(lactic-co-glycolic acid) polymer, and combinations thereof. The tissue scaffolds have high open volume % enabling superior (linear and high fidelity) neural tissue growth, while minimizing inflammation near the site of implantation in vivo. In other aspects, methods of making such tissue scaffolds are provided. Such a method may include mixing a reduced particle size porogen with a polymeric precursor solution. The material is cast onto a template and then can be processed, including assembly in a sheath and removal of the porogen, to form a tissue scaffold having a plurality of porous microchannels.
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公开(公告)号：US20180251454A1
公开(公告)日：2018-09-06
申请号：US15759884
申请日：2016-09-16
Applicant: Board of Regents, The University of Texas System , Board of Regents, The University of Texas System
Inventor： Waldemar PRIEBE , Liwei GUO , Arkadiusz KAZIMIERSKI , Izabela FOKT , Charles CONRAD , Timothy MADDEN
IPC: C07D405/14 , C07D405/12 , A61P35/00
CPC classification number: C07D405/14 , A61P35/00 , C07C13/66 , C07D309/14 , C07D405/12 , C07H15/24 , C07H15/244
Abstract: Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.
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公开(公告)号：US20180043039A1
公开(公告)日：2018-02-15
申请号：US15797816
申请日：2017-10-30
Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF HOUSTON SYSTEM , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , ALZECA BIOSCIENCES, LLC
Inventor： Ananth V. Annapragada , Jason L. Eriksen , Eric A. Tanifum , Indrani Dasgupta , Stephen C. Cook
IPC: A61K49/18 , C08G65/335 , A61K9/127
CPC classification number: A61K49/1812 , A61K9/1273 , A61K47/6911 , A61K49/0466 , C08G65/3353
Abstract: Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.
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公开(公告)号：US20170218017A1
公开(公告)日：2017-08-03
申请号：US15263028
申请日：2016-09-12
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , INTEZYNE TECHNOLOGIES INC. , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： ROBERT J. GILLIES , DAVID L. MORSE , NATALIE M. BARKEY , KEVIN N. SILL , JOSEF VAGNER , NARGES K. TAFRESHI , JONATHAN L. SESSLER , CHRISTIAN PREIHS , VICTOR J. HRUBY
CPC classification number: C07K5/1024 , A61K38/34 , A61K47/64 , A61K47/6907 , A61K49/0056 , A61K49/101 , A61K49/1809 , C07K7/08 , C07K14/68 , C07K14/723
Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
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