公开(公告)号：US20210401964A1

公开(公告)日：2021-12-30

申请号：US17468989

申请日：2021-09-08

申请人： Sanofi Pasteur Inc.

发明人： Richard David Kensinger, JR. ,  Steven L. Hauser

IPC分类号： A61K39/095 ,  A61K47/65 ,  A61K47/64 ,  A61K47/18 ,  A61K47/36

摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

公开(公告)号：US11147866B2

公开(公告)日：2021-10-19

申请号：US16282080

申请日：2019-02-21

申请人： Sanofi Pasteur Inc.

发明人： Richard David Kensinger, Jr. ,  Steven L. Hauser

IPC分类号： A61K39/095 ,  A61K47/65 ,  A61K47/64 ,  A61K47/18 ,  A61K47/36 ,  A61K39/00

摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

公开(公告)号：US11116832B2

公开(公告)日：2021-09-14

申请号：US16306325

申请日：2017-06-02

申请人： Sanofi Pasteur Inc.

发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/18 ,  C07K16/28 ,  A61K45/06 ,  A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  C12N7/00

摘要： The present invention provides, among other things, modified recombinant HA polypeptides with broadened immunogenic profile that extends coverage to antigenically distinct influenza strains and methods of making and using the same.

公开(公告)号：US20210186809A1

公开(公告)日：2021-06-24

申请号：US17263334

申请日：2019-07-26

申请人： Sanofi Pasteur

发明人： Christophe DeJonghe ,  Ludovic Giroud ,  Teddy Klein ,  Philippe Revolte

IPC分类号： A61J1/05 ,  B65D77/04 ,  B65D5/42 ,  B65D5/66

摘要： The packaging unit includes an inner enclosure (11) within which is contained each said pharmaceutical product (12), a patient or health care professional information leaflet (13) and outer enclosure (14) including: —a first outer enclosure (15) within which is contained said inner enclosure (11); and —a second outer enclosure (16) within which is contained said first outer enclosure (15) and said information leaflet (13); said second outer enclosure (16) being provided with labelling features; said second outer enclosure having an opening (37) arranged so that traceability and anti-counterfeiting features are visible through said opening (37).

公开(公告)号：US20210077608A1

公开(公告)日：2021-03-18

申请号：US16966584

申请日：2019-02-04

申请人： SANOFI PASTEUR INC. ,  SK BIOSCIENCE CO., LTD.

发明人： Kyungjun AN ,  Dongsoo HAM ,  Hun KIM ,  Sunghyun KIM ,  Jinhwan SHIN ,  Robert HOPFER ,  Richard D. KENSINGER ,  Moe KYAW ,  Philippe TALAGA

IPC分类号： A61K39/09

摘要： Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.

公开(公告)号：US20210025827A1

公开(公告)日：2021-01-28

申请号：US16982244

申请日：2019-03-19

申请人： Sanofi Pasteur Limited

发明人： Salvador Fernando AUSAR ,  Cristopher ROQUE ,  Kirsten April STRAHLENDORF ,  Nausheen RAHMAN

IPC分类号： G01N21/64 ,  G01N33/58

摘要： Methods and systems for determining the concentration of compounds, such as proteins, in compositions comprising adjuvanted complexes of the compounds are provided. The methods and systems generally comprise (i) measuring the intrinsic fluorescence of a composition comprising adjuvanted complexes of the compound and (ii) comparing the measured fluorescence intensity value to a calibration curve prepared using known concentrations of the compound. Also provided are methods and systems for determining percent adsorption of a selected compound to an adjuvant.

公开(公告)号：US10857222B2

公开(公告)日：2020-12-08

申请号：US15740889

申请日：2016-07-01

申请人： SANOFI PASTEUR

发明人： Fernando Noriega ,  Betzana Zambrano ,  Nadia Tornieporth ,  Mélanie Saville ,  Eric Plennevaux ,  Mark Boaz ,  Thomas Papa

IPC分类号： A61K39/12 ,  A61K39/295 ,  C07K14/18 ,  A61K39/00

摘要： The present invention relates to a yellow fever (YF) vaccine for use in a method for inducing a protective immune response against yellow fever, wherein said method comprises concomitantly administering said yellow fever vaccine to a human subject together with a tetravalent dengue vaccine which comprises a live attenuated dengue virus of each of serotypes 1 to 4. This invention also pertains to a tetravalent dengue vaccine which comprises a live attenuated dengue virus of each of serotypes 1 to 4 for use in a method of inducing a protective immune response against yellow fever, wherein said method comprises concomitantly administering said tetravalent dengue vaccine to a human subject together with a yellow fever (YF) vaccine.

公开(公告)号：US20200289637A1

公开(公告)日：2020-09-17

申请号：US16652902

申请日：2018-10-05

申请人： Sanofi Pasteur

发明人： Diana Coronel ,  Betzana Zambrano ,  Fernando Noriega ,  Tram Anh Wartel

IPC分类号： A61K39/12 ,  A61P31/14

摘要： The present invention is directed to a method of booster vaccination and to a vaccine composition for use in such a method, for inducing in a human subject a neutralizing antibody response, wherein said subject has previously received a primary vaccination against each of serotypes 1 to 4 of dengue virus and was dengue naïve before said primary vaccination, said composition comprising a dengue antigen of at least one of serotypes 1 to 4 or a nucleic acid construct capable of expressing said antigens in the subject, wherein said booster vaccination results in a 2-fold increase in the neutralizing antibody titre against each of serotypes 1 to 4. The invention is also directed to a method of inducing in a human subject a neutralizing antibody response comprising the administration of a vaccine composition, or to a vaccine composition for use in such a method, said composition comprising a dengue antigen of each of serotypes 1 to 4, or a nucleic acid construct capable of expressing in said subject a dengue antigen of each of serotypes 1 to 4; wherein said composition is administered as a primary vaccination, followed by a booster vaccination, and wherein the human subject is initially dengue naïve.

公开(公告)号：US20190201517A1

公开(公告)日：2019-07-04

申请号：US16123319

申请日：2018-09-06

申请人： SANOFI PASTEUR

发明人： Alain Bouckenooghe ,  Remi Forrat ,  Jean Lang ,  Mélanie Saville ,  Nadia Tornieporth

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/70 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/388

摘要： The present invention relates to vaccine compositions that are useful in a method of protecting a human subject against dengue disease.

公开(公告)号：US20190194626A1

公开(公告)日：2019-06-27

申请号：US16230990

申请日：2018-12-21

申请人： Sanofi Pasteur Biologics, LLC

发明人： Simon Delagrave ,  CharChang Lai

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16651 ,  A61K2300/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K35/76 ,  A61K2039/525 ,  C12N15/86 ,  C12N2710/16643 ,  C12N2710/16034 ,  C12N2710/16611 ,  C12N15/869 ,  C12N2710/16652 ,  C12N2710/16661 ,  C07K14/005 ,  C07K14/035

摘要： Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.