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    Engineered influenza antigenic polypeptides and immunogenic compositions thereof
    7.
    发明授权
    Engineered influenza antigenic polypeptides and immunogenic compositions thereof 有权

    公开(公告)号：US11325947B2

    公开(公告)日：2022-05-10

    申请号：US16751963

    申请日：2020-01-24

    申请人： SANOFI PASTEUR INC.

    发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

    IPC分类号： A61K39/145 ,  C07K14/005 ,  C07K14/11 ,  A61K39/00 ,  A61K39/12 ,  A61K9/00 ,  A61K39/39 ,  C12N9/24

    摘要： The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (HA) and neuraminidase (NA) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple HA or NA sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered H1N1 influenza hemagglutinin (HA) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple H1N1 viral strains. Such engineered HA polypeptides have improved properties over HA polypeptides developed through conventional approaches that rely on consensus alignments of viral sequences.

    ENGINEERED INFLUENZA ANTIGENIC POLYPEPTIDES AND IMMUNOGENIC COMPOSITIONS THEREOF
    9.
    发明申请
    ENGINEERED INFLUENZA ANTIGENIC POLYPEPTIDES AND IMMUNOGENIC COMPOSITIONS THEREOF 审中-公开

    公开(公告)号：US20200223892A1

    公开(公告)日：2020-07-16

    申请号：US16751963

    申请日：2020-01-24

    申请人： SANOFI PASTEUR INC.

    发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

    IPC分类号： C07K14/005 ,  A61K9/00 ,  A61K39/145 ,  A61K39/39 ,  C12N9/24

    摘要： The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (HA) and neuraminidase (NA) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple HA or NA sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered H1N1 influenza hemagglutinin (HA) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple H1N1 viral strains. Such engineered HA polypeptides have improved properties over HA polypeptides developed through conventional approaches that rely on consensus alignments of viral sequences.

    Engineered influenza antigenic polypeptides and immunogenic compositions thereof
    10.
    发明授权
    Engineered influenza antigenic polypeptides and immunogenic compositions thereof 有权

    公开(公告)号：US10584148B2

    公开(公告)日：2020-03-10

    申请号：US15578880

    申请日：2016-06-02

    申请人： SANOFI PASTEUR INC.

    发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

    IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K39/42 ,  C07K14/11 ,  C07K14/005 ,  A61K9/00 ,  A61K39/39 ,  C12N9/24

    摘要： The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (HA) and neuraminidase (NA) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple HA or NA sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered H1N1 influenza hemagglutinin (HA) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple H1N1 viral strains. Such engineered HA polypeptides have improved properties over HA polypeptides developed through conventional approaches that rely on consensus alignments of viral sequences.