公开(公告)号：US11587270B2

公开(公告)日：2023-02-21

申请号：US17100114

申请日：2020-11-20

Applicant: Xiamen University

Inventor： Shuhui Cai ,  Chenlu Guo ,  Congbo Cai ,  Jian Wu

IPC: G06T11/00 ,  G16H50/50 ,  G16H30/40 ,  G06K9/62 ,  G06N3/08

Abstract: Disclosed is a method for reconstruction of a Chemical Exchange Saturation Transfer (CEST) contrast image. The method includes: generating training samples for a deep neural network; training the deep neural network with the training samples to obtain a trained deep neural network; and reconstructing a CEST contrast image by using the trained deep neural network and PROPELLER undersampled CEST images. The method for reconstruction of a CEST contrast image can effectively shorten the experimental time of a CEST contrast imaging and can obtain a smoother and more accurate CEST contrast image. Further disclosed is a system for reconstruction of a CEST contrast image to implement the method for reconstruction.

公开(公告)号：US11489205B2

公开(公告)日：2022-11-01

申请号：US16874795

申请日：2020-05-15

Applicant: Xiamen University

Inventor： Yong Yang ,  Liangfan Xu ,  Yixiao Li ,  Jun Gao ,  Huajin He

IPC: H01M10/0569 ,  H01M10/0525 ,  H01M4/134 ,  H01M4/131 ,  H01M4/505 ,  H01M50/44 ,  H01M50/431 ,  H01M4/02

Abstract: The present disclosure discloses a primary lithium battery comprising a reactive solid cathode, a liquid electrolyte, a separator, and a lithium anode. The liquid electrolyte is ionic conductive and is configured to undergo a series coupling reaction after solid phase reaction of the reactive solid cathode and the lithium anode. The liquid electrolyte comprises a solvent and an electrolyte salt, and a concentration of the electrolyte salt in the liquid electrolyte is 0.1-3 mol/L. The solvent comprises a sulfite ester type compound and an organic solvent, and a concentration of the sulfite ester type compound in the organic solvent is 5 wt % to 90 wt %.

公开(公告)号：US11476501B2

公开(公告)日：2022-10-18

申请号：US17105517

申请日：2020-11-26

Applicant: XIAMEN UNIVERSITY

Inventor： Ling Huang ,  Qiong Wang ,  Ying Lei ,  Chenguang Shi ,  Shigang Sun

IPC: H01M4/04 ,  H01M10/0567 ,  H01M4/134 ,  H01M4/136 ,  H01M4/66 ,  H01M10/0525 ,  H01M10/0568 ,  H01M10/0569 ,  H01M4/02

Abstract: The invention discloses a lithium metal anode protection method improving lithium utilization efficiency, and relates to the field of lithium batteries. In a lithium battery, lithium metal is deposited on a current collector as a battery anode, and a high molecular polymer is added as an additive to an ester electrolyte. In the present application, the high molecular polymer is prepared by a polymerization reaction of monomer A being acrylonitrile or derivatives thereof, monomer B being perfluoroalkyl ethyl methacrylate or derivatives thereof, and monomer C being alkyl alcohol diacrylate or derivatives thereof. Due to the negative charge on the surface of lithium metal, the —CN and —CF3 in the polymer are strong electron-withdrawing groups, which promote the preferential adsorption of electrolyte additives on the surface of lithium metal and reduce the contact of other components in the electrolyte with lithium metal.

公开(公告)号：US11464846B2

公开(公告)日：2022-10-11

申请号：US15734750

申请日：2019-06-04

Applicant: Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

Inventor： Shaowei Li ,  Xinlin Liu ,  Yurou Yang ,  Jie Chen ,  Daning Wang ,  Ningshao Xia

IPC: A61K39/12 ,  C07K14/025 ,  C12N7/00 ,  A61K39/00

Abstract: The invention relates to a mutated HPV66 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV66 and HPV56, or HPV66, HPV56 and HPV53), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：US20220289661A1

公开(公告)日：2022-09-15

申请号：US17689425

申请日：2022-03-08

Applicant: Xiamen University

Inventor： Nuowei Zhang ,  Xinliang Lin ,  Binghui Chen ,  Lili Guo ,  Fan Cai ,  Songshou Ye ,  Jianrong Xie ,  Jinbao Zheng

IPC: C07C67/37 ,  B01J29/24 ,  B01J37/00 ,  B01J37/18

Abstract: A carbonylation-dehydration dual-functional catalyst precursor, a preparation method thereof, a carbonylation-dehydration dual-functional catalyst and use thereof are provided. The carbonylation-dehydration dual-functional catalyst precursor includes a modified silica-aluminum molecular sieve having an 8-member ring channel structure; a modified metal oxie loaded on the modified silica-aluminum molecular sieve having an 8-member ring channel structure by coupling, the coupling being performed using a silane coupling agent, wherein a modified component in the modified silica-aluminum molecular sieve having an 8-member ring channel structure includes at least one selected from the group consisting of copper oxide, zing oxide and iron oxide, and has a loading amount of 0.5-5 wt %, based on a metal mass of the modified component; and the modified metal oxie is prepared by modifying a composite metal oxide with an acid solution or an alkali solution, wherein the composite metal oxide is prepared based on a co-precipitation-calcination method.

公开(公告)号：US20220249668A1

公开(公告)日：2022-08-11

申请号：US17572560

申请日：2022-01-10

Applicant: Xiamen University

Inventor： Ming CHEN ,  Haojie Zhai

IPC: A61K41/00 ,  A61K9/00 ,  A61K47/46

Abstract: A drug transdermal delivery system comprises sponge spicules and a low-frequency sonophoresis device, the drug transdermal delivery system firstly applies a low-frequency sonophoresis to skin using the low-frequency sonophoresis device, a surface of the skin is then massaged with the sponge spicules.

公开(公告)号：US20220235117A1

公开(公告)日：2022-07-28

申请号：US17613322

申请日：2020-05-22

Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

Inventor： Wenxin LUO ,  Can WEN ,  Xinchu XIANG ,  Jixian TANG ,  Yangtao WU ,  Tianying ZHANG ,  Quan YUAN ,  Ningshao XIA

IPC: C07K16/08 ,  A61P31/20

Abstract: Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.

公开(公告)号：US20220214657A1

公开(公告)日：2022-07-07

申请号：US17703074

申请日：2022-03-24

Applicant: c/o Xiamen University of Technology

Inventor： Ying MA ,  Shunzhi ZHU ,  Yu SUN ,  Junwen LU ,  Keshou WU

IPC: G05B19/042

Abstract: The present disclosure discloses a monitoring management and control system based on panoramic big data comprising an imaging device, a credential of the imaging device, a memory, a networking device, and a processing unit. The imaging device is configured to detect a first object and determine an approximate location of the first object and a reliability value of the approximate location of the first object based on the credential of the imaging device, the memory, the networking device, and the processing unit.

公开(公告)号：US11371821B2

公开(公告)日：2022-06-28

申请号：US16183737

申请日：2018-11-08

Applicant: Xiamen University

Inventor： Bin Yao ,  Zhiqin Cai ,  Binqiang Chen

IPC: G01B5/20 ,  G06T7/13 ,  G06T7/00 ,  B23F21/06 ,  B23F23/12 ,  G01B7/14

Abstract: A method for extracting a gear tooth profile edge based on an engagement-pixel image edge tracking method includes defining a transmission ratio relationship between a cutter and an envelope tooth profile, setting a cutter profile step size and an envelope step size, acquiring instantaneous contact images at different engaging times, and performing a binarization processing on each curve envelope cluster image; sweeping a boundary of an envelope curve cluster, acquiring pixel points of the edge; preliminarily tracking a tooth profile edge, and then performing a secondary extraction and compensation on the pixel points; calibrating coordinates of a cutter profile; extracting a pixel coordinate of an instantaneous engaging point; converting the pixel points among different instantaneous engaging images; extracting a final tooth profile coordinate of the gear, and performing a tooth shape error analysis and a contact line error analysis.

公开(公告)号：US20220146515A1

公开(公告)日：2022-05-12

申请号：US17295361

申请日：2019-11-06

Applicant: Xiamen Innodx Biotech Co. Ltd. ,  Xiamen University

Inventor： Junhui XIONG ,  Zimin CHEN ,  Weiling XU ,  Long WANG ,  Qishen KE ,  Lihua LI ,  Liuwei SONG ,  Xudong SUN ,  Shengxiang GE

IPC: G01N33/577 ,  G01N33/74 ,  C07K16/26

Abstract: The present invention belongs to the field of biomedical laboratory science, and provides a specific antibody for AMH and uses thereof.