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公开(公告)号：US07541046B1
公开(公告)日：2009-06-02
申请号：US12151230
申请日：2008-05-05
申请人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A01J21/00
CPC分类号： A61K9/5146 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US07381716B2
公开(公告)日：2008-06-03
申请号：US11398145
申请日：2006-04-05
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
IPC分类号： A01N43/04
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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公开(公告)号：US07291598B2
公开(公告)日：2007-11-06
申请号：US11398440
申请日：2006-04-05
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/5161 , A61K47/36 , A61K47/6931 , A61K47/6939 , B82Y5/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷和增强细胞旁药物递送的渗透性。
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公开(公告)号：US07282194B2
公开(公告)日：2007-10-16
申请号：US11284734
申请日：2005-11-21
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚-γ-谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其对细胞旁药物递送的增强的渗透性。
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公开(公告)号：US07265090B2
公开(公告)日：2007-09-04
申请号：US11029082
申请日：2005-01-04
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan/poly-γ-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖/聚-γ-谷氨酸组成的纳米颗粒，其特征在于具有阳性表面电荷并且通过Caco-2细胞提高细胞外药物递送的通透性。
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公开(公告)号：US20070116771A1
公开(公告)日：2007-05-24
申请号：US11398145
申请日：2006-04-05
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
IPC分类号： A61K31/55 , A61K31/445 , A61K31/13 , A61K9/14
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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公开(公告)号：US20070092493A1
公开(公告)日：2007-04-26
申请号：US11256729
申请日：2005-10-24
申请人： Hsing-Wen Sung , Chun-Hung Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Chun-Hung Chen , Hosheng Tu
CPC分类号： C12N5/0068 , C12N2539/10
摘要： A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet with ECM. The coated hydrogel system is reusable and can be used for culturing a multi-layer cell sheet. The obtained living cell sheets may be used for tissue reconstructions.
摘要翻译： 一种新颖的方法，使用涂覆在TCPS皿上的热可逆MC / PBS /胶原水凝胶，用ECM收集活细胞片。 涂覆的水凝胶体系是可重复使用的，可用于培养多层细胞片。 获得的活细胞片可以用于组织重建。
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公开(公告)号：US20070014831A1
公开(公告)日：2007-01-18
申请号：US11180498
申请日：2005-07-12
申请人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B17/1219 , A61B2017/00004 , A61B2017/1205 , A61F2/82 , A61F2002/30062 , A61F2210/0004 , A61K31/337 , A61K31/436 , A61K47/61 , A61K47/6957 , C08B37/003 , C08B37/0084
摘要： The present invention relates to a biodegradable occlusive device and methods for treating aneurysm of a patient comprising deploying a flexible biodegradable occlusive device with a moisture memory and a controlled biodegradation, and deploying a retaining stent for preventing the occlusive device from being inadvertently dislodged from the sac.
摘要翻译： 本发明涉及可生物降解的闭塞装置和用于治疗患者的动脉瘤的方法，包括部署具有湿气记忆和受控生物降解的柔性可生物降解闭塞装置，以及展开保持支架以防止闭塞装置被无意中从囊中移出 。
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公开(公告)号：US08461316B1
公开(公告)日：2013-06-11
申请号：US12807562
申请日：2010-09-08
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
IPC分类号： C07H21/04
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55 , A61K47/61 , A61K47/645
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one DNA, RNA or bioactive agent characterized with a positive surface charge and their enhanced efficiency for gene delivery and bioactive agent delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种DNA，RNA或生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其增强的基因递送和生物活性剂递送效率。
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公开(公告)号：US08454966B2
公开(公告)日：2013-06-04
申请号：US12807084
申请日：2010-08-27
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K38/14 , A61K31/715 , A61K47/36
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚-γ-谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其对细胞旁药物递送的增强的渗透性。
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