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公开(公告)号：US08008055B2
公开(公告)日：2011-08-30
申请号：US12194364
申请日：2008-08-19
申请人： Takashi Uemori , Yoshimi Sato , Nobuto Koyama , Ryo Hirano , Hikaru Takakura , Hiroshi Kobori , Yuji Hashimoto , Kikyozo Asada , Ikunoshin Kato
发明人： Takashi Uemori , Yoshimi Sato , Nobuto Koyama , Ryo Hirano , Hikaru Takakura , Hiroshi Kobori , Yuji Hashimoto , Kikyozo Asada , Ikunoshin Kato
CPC分类号： C12N9/22
摘要： Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
摘要翻译： 具有在遗传工程中非常有用的RNase H活性的多肽; 编码这些多肽的基因; 以及用于遗传工程化生产这些多肽的方法。
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公开(公告)号：US08003781B2
公开(公告)日：2011-08-23
申请号：US12281601
申请日：2007-03-02
申请人： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
发明人： Akihiro Kondo , Wenzhe Li , Takatoshi Nakagawa , Nobuto Koyama , Naoyuki Taniguchi , Ikunoshin Kato
CPC分类号： C12N15/1137 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12Y204/01068
摘要： Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.
摘要翻译： 公开了减少FUT8基因的表达量，降低FUT8蛋白的表达量和/或降低由FUT8的作用产生的产物的表达量的方法。
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公开(公告)号：US06518317B1
公开(公告)日：2003-02-11
申请号：US09367185
申请日：1999-08-09
IPC分类号： A61K31122
CPC分类号： C07C323/58 , A23K20/105 , A23L2/52 , A23L33/10 , A61K31/122 , C07C323/59 , Y10S514/894
摘要： An antiviral agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译： 一种抗病毒剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为 有效成分。
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94.发明授权Enzymes capable of degrading a sulfated-fucose-containing polysaccharide and their encoding genes 失效能够降解含硫酸化岩藻糖多糖及其编码基因的酶公开(公告)号：US06489155B1
公开(公告)日：2002-12-03
申请号：US09486072
申请日：2000-02-22
IPC分类号： C12N924
CPC分类号： C12N9/00 , C12N9/2402 , C12Y302/01044
摘要： An isolated gene having a DNA sequence coding for the polypeptide having a degrading activity of the sulfated-fucose-containing polysaccharide or having the functionally identical activity as above.
摘要翻译： 具有编码具有含硫酸化岩藻糖多糖的降解活性或具有与上述功能相同的活性的多肽的DNA序列的分离基因。
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95.发明授权Hyperthermostable .beta.-galactosidase gene, enzyme encoded thereby, and process for production 失效超热稳定性β-半乳糖苷酶基因，由此编码的酶，以及生产方法
公开(公告)号：US5962326A
公开(公告)日：1999-10-05
申请号：US993581
申请日：1997-12-18
申请人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
发明人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
CPC分类号： C12Y302/01023 , C12N9/2471
摘要： An isolated SDS-resistant hyperthermostable .beta.-galactosidase gene derived from Pyrococcus furiosus. Examples thereof include genes respectively shown in SEQ ID NO: 1 and SEQ ID NO: 2 and genes each hybridizable with the above gene shown in SEQ ID NO: 1. A method of cloning the hyperthermostable .beta.-galactosidase gene in which each of the above genes or pacts thereof is used as a probe or primer. A process for producing a hyperthermostable .beta.-galactosidase by culturing a transformant into which a plasmid containing each of the above gene has been introduced.
摘要翻译： 来自激烈热球菌的分离的耐SDS耐热超β-半乳糖苷酶基因。 其实例包括分别显示在SEQ ID NO：1和SEQ ID NO：2中的基因以及各自可与SEQ ID NO：1所示的上述基因杂交的基因。一种克隆其中每个上述的高热稳定性β-半乳糖苷酶基因的方法 基因或其结合物用作探针或引物。 通过培养引入含有上述每种基因的质粒的转化体来生产超热稳定性β-半乳糖苷酶的方法。
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公开(公告)号：US07678368B2
公开(公告)日：2010-03-16
申请号：US11311341
申请日：2005-12-20
申请人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
摘要翻译： 为了找到具有防止皮肤老化，敏感性皮肤的改善或止痒作用的皮肤美容效果的物质，可以作为护发品的有效成分，从而提供含有效成分的化妆品。 具体地，提供了化妆品，其特征在于，所述化妆品包含选自岩藻依聚糖，其降解产物，硫酸化单糖或其盐的化合物作为有效成分。
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公开(公告)号：US20060093566A1
公开(公告)日：2006-05-04
申请号：US11311341
申请日：2005-12-20
申请人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K8/73
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
摘要翻译： 为了找到具有防止皮肤老化，敏感性皮肤的改善或止痒作用的皮肤美容效果的物质，可以作为护发品的有效成分，从而提供含有效成分的化妆品。 具体地，提供了化妆品，其特征在于，所述化妆品包含选自岩藻依聚糖，其降解产物，硫酸化单糖或其盐的化合物作为有效成分。
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公开(公告)号：US08344105B2
公开(公告)日：2013-01-01
申请号：US13239981
申请日：2011-09-22
申请人： Yoshimi Sato , Kazue Nishiwaki , Nana Shimada , Shigekazu Hokazono , Takashi Uemori , Hiroyuki Mukai , Ikunoshin Kato
发明人： Yoshimi Sato , Kazue Nishiwaki , Nana Shimada , Shigekazu Hokazono , Takashi Uemori , Hiroyuki Mukai , Ikunoshin Kato
CPC分类号： C12Q1/686 , C12N9/1252 , C12Q2521/101
摘要： A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.
摘要翻译： 具有高保真DNA聚合酶活性的多肽，因此可用作遗传工程试剂; 编码该多肽的基因; 一种产生该多肽的方法; 以及通过使用多肽扩增核酸的方法。
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公开(公告)号：US20120009162A1
公开(公告)日：2012-01-12
申请号：US13257389
申请日：2010-04-02
IPC分类号： A61K35/12 , C12N15/63 , A61P35/00 , C07K14/435 , C07H21/04 , C12N5/10 , A61K31/7088
CPC分类号： C07K14/7051 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K48/00 , C12N2740/13043
摘要： Disclosed are: polypeptides for TCR α-chain and β-chain which are restricted to HLA-A*0201 for Aur-A and are derived from a CTL; and nucleic acids encoding the polypeptides. The nucleic acids can impart a cytotoxic activity against a cell capable of presenting an HLA-A*0201 molecule and an Aur-A207-215 peptide thereon to a T cell, and are therefore useful for the treatment of cancer in which Aur-A is expressed.
摘要翻译： 公开的是：针对Aur-A限制于HLA-A * 0201并衍生自CTL的TCRα链和链长多肽; 和编码多肽的核酸。 核酸可以对能够将HLA-A * 0201分子和Aur-A207-215肽呈递给T细胞的细胞赋予细胞毒性活性，因此可用于治疗Aur-A为 表达。
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公开(公告)号：US20110250230A1
公开(公告)日：2011-10-13
申请号：US13062999
申请日：2009-09-11
申请人： Hiroshi Shiku , Hiroaki Ikeda , Jun Mitsui , Yuki Takenaka , Junichi Mineno , Ikunoshin Kato
发明人： Hiroshi Shiku , Hiroaki Ikeda , Jun Mitsui , Yuki Takenaka , Junichi Mineno , Ikunoshin Kato
CPC分类号： A61K39/0005 , A61K35/12 , A61K38/00 , A61K38/191 , A61K39/0011 , A61K2039/5152 , A61K2039/5156 , C07K14/70575 , C07K2319/30 , C12N2799/022 , C12N2799/027
摘要： Disclosed are: a cell capable of expressing an exogenous GITRL or an exogenous GITRL derivative; a method for producing the cell; a therapeutic or prophylactic agent comprising the cell as an active ingredient; use of the cell in the manufacture of a therapeutic or prophylactic agent; a method comprising a step of administering the cell to a subject; a viral vector carrying a gene encoding a GITRL or a GITRL derivative; a therapeutic or prophylactic agent comprising the viral vector as an active ingredient; use of the viral vector in the manufacture of a therapeutic or prophylactic agent; and a method comprising a step of administering the viral vector to a subject.
摘要翻译： 公开了能够表达外源GITRL或外源性GITRL衍生物的细胞; 电池的制造方法; 包含该细胞作为活性成分的治疗或预防剂; 在制造治疗或预防剂中使用细胞; 一种方法，包括将细胞施用于受试者的步骤; 携带编码GITRL或GITRL衍生物的基因的病毒载体; 包含病毒载体作为活性成分的治疗或预防剂; 病毒载体在制备治疗或预防药物中的应用; 以及包括将病毒载体施用于受试者的步骤的方法。
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