公开(公告)号：US08003781B2

公开(公告)日：2011-08-23

申请号：US12281601

申请日：2007-03-02

申请人： Akihiro Kondo ,  Wenzhe Li ,  Takatoshi Nakagawa ,  Nobuto Koyama ,  Naoyuki Taniguchi ,  Ikunoshin Kato

发明人： Akihiro Kondo ,  Wenzhe Li ,  Takatoshi Nakagawa ,  Nobuto Koyama ,  Naoyuki Taniguchi ,  Ikunoshin Kato

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C12N15/1137 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/14 ,  C12Y204/01068

摘要： Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.

摘要翻译： 公开了减少FUT8基因的表达量，降低FUT8蛋白的表达量和/或降低由FUT8的作用产生的产物的表达量的方法。

公开(公告)号：US20090221065A1

公开(公告)日：2009-09-03

申请号：US12281601

申请日：2007-03-02

申请人： Akihiro Kondo ,  Wenzhe Li ,  Takatoshi Nakagawa ,  Nobuto Koyama ,  Naoyuki Taniguchi ,  Ikunoshin Kato

发明人： Akihiro Kondo ,  Wenzhe Li ,  Takatoshi Nakagawa ,  Nobuto Koyama ,  Naoyuki Taniguchi ,  Ikunoshin Kato

IPC分类号： C12N15/63 ,  C07H21/02

CPC分类号： C12N15/1137 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/14 ,  C12Y204/01068

摘要： Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.

摘要翻译： 公开了减少FUT8基因的表达量，降低FUT8蛋白的表达量和/或降低由FUT8的作用产生的产物的表达量的方法。

公开(公告)号：US06482806B1

公开(公告)日：2002-11-19

申请号：US09125397

申请日：1998-08-18

申请人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： A61K31727

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.

摘要翻译： 通过加热选自以下（a），（b）和（c）中的至少一种物质获得的产物：（a）糖醛酸或糖醛酸衍生物;（b）含有糖醛酸或含有糖醛酸的糖类化合物的糖类化合物 酸衍生物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质;以及含有上述热处理物的食品，饮料或药剂。

公开(公告)号：US20050202064A1

公开(公告)日：2005-09-15

申请号：US11114071

申请日：2005-04-26

申请人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hiroaki Sagawa ,  Eiji Kobayashi ,  Tatsuji Enoki ,  Hua-Kang Wu ,  Eiji Nishiyama ,  Suzu Deguchi ,  Katsushige Ikai ,  Hiromu Ohnogi ,  Motoko Ueda ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： A23L3/3562 ,  A61K8/60 ,  A61K31/19 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/715 ,  A61K31/727 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/737 ,  A61K35/00 ,  A61K35/12 ,  A61K35/74 ,  A61K36/00 ,  A61L2/16 ,  A61P35/00 ,  A61Q11/00 ,  C07H7/033 ,  C08B37/00

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a saccharide compound containing uronic acid or a substance containing a saccharide compound containing uronic acid derivative; and food, beverage or a pharmaceutical agent which is characterized in containing the above-mentioned heat-treated product.

摘要翻译： 通过加热至少一种选自以下（a），（b）和（c）的物质而得到的产物。 （a）糖醛酸或糖醛酸衍生物; （b）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物; 和（c）含有糖醛酸的糖类化合物或含有糖醛酸衍生物的糖类化合物的物质的物质; 以及食品，饮料或药剂，其特征在于含有上述热处理产品。

公开(公告)号：US08043832B2

公开(公告)日：2011-10-25

申请号：US12301294

申请日：2007-05-18

申请人： Eiji Miyoshi ,  Hideki Iijima ,  Shinichiro Shinzaki ,  Masahiko Tsujii ,  Norio Hayashi ,  Takatoshi Nakagawa ,  Akihiro Kondo ,  Naoyuki Taniguchi

发明人： Eiji Miyoshi ,  Hideki Iijima ,  Shinichiro Shinzaki ,  Masahiko Tsujii ,  Norio Hayashi ,  Takatoshi Nakagawa ,  Akihiro Kondo ,  Naoyuki Taniguchi

IPC分类号： C12P21/04

CPC分类号： G01N33/6893 ,  G01N33/6854 ,  G01N2400/00 ,  G01N2800/065 ,  G01N2800/38 ,  G01N2800/60

摘要： The instant invention provides a method for the differential diagnosis of inflammatory bowel disease which comprises,determining the relative ratio of G0 oligosaccharide represented by formula (I): to G2 oligosaccharide represented by formula (II): wherein G represents galactose, M represents mannose, GN represents N-acetylglucosamine and F represents fucose in serum IgG oligosaccharide fraction obtained from a patient with inflammatory bowel disease or a patient with suspicion of inflammatory bowel disease, and discriminating inflammatory bowel disease based on the obtained ratio.

摘要翻译： 本发明提供了一种炎症性肠病鉴别诊断方法，其特征在于，测定由式（I）表示的G0寡糖与式（II）表示的G2寡糖的相对比例：G表示半乳糖，M表示甘露糖， GN表示N-乙酰葡糖胺，F表示从患有炎症性肠病的患者获得的血清IgG寡糖部分中的岩藻糖或具有炎症性肠病的疑似患者，根据所得比例鉴别炎症性肠病。

公开(公告)号：US20090186371A1

公开(公告)日：2009-07-23

申请号：US12301294

申请日：2007-05-18

申请人： Eiji Miyoshi ,  Hideki Iijima ,  Shinichiro Shinzaki ,  Masahiko Tsujii ,  Norio Hayashi ,  Takatoshi Nakagawa ,  Akihiro Kondo ,  Naoyuki Taniguchi

发明人： Eiji Miyoshi ,  Hideki Iijima ,  Shinichiro Shinzaki ,  Masahiko Tsujii ,  Norio Hayashi ,  Takatoshi Nakagawa ,  Akihiro Kondo ,  Naoyuki Taniguchi

IPC分类号： C12Q1/37

CPC分类号： G01N33/6893 ,  G01N33/6854 ,  G01N2400/00 ,  G01N2800/065 ,  G01N2800/38 ,  G01N2800/60

摘要： The instant invention provides a method for the differential diagnosis of inflammatory bowel disease which comprises,determining the relative ratio of G0 oligosaccharide represented by formula (I): to G2 oligosaccharide represented by formula (II): wherein G represents galactose, M represents mannose, GN represents N-acetylglucosamine and F represents fucose in serum IgG oligosaccharide fraction obtained from a patient with inflammatory bowel disease or a patient with suspicion of inflammatory bowel disease, and discriminating inflammatory bowel disease based on the obtained ratio.

摘要翻译： 本发明提供了一种炎症性肠病鉴别诊断方法，其特征在于，测定由式（I）表示的G0寡糖与式（II）表示的G2寡糖的相对比例：G表示半乳糖，M表示甘露糖， GN表示N-乙酰葡糖胺，F表示从患有炎症性肠病的患者获得的血清IgG寡糖部分中的岩藻糖或具有炎症性肠病的疑似患者，根据所得比例鉴别炎症性肠病。

公开(公告)号：US5500342A

公开(公告)日：1996-03-19

申请号：US288768

申请日：1994-08-11

申请人： Tsuyoshi Miyamura ,  Mutsumi Sano ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Tsuyoshi Miyamura ,  Mutsumi Sano ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： C12Q1/34 ,  C07H3/06 ,  C07H5/04 ,  C07H13/04 ,  C07H15/12 ,  C07H15/26 ,  G01N33/50 ,  G01N33/574 ,  C12Q1/00 ,  C07G3/00 ,  C07H19/00 ,  C12Q1/54

CPC分类号： C07H13/04 ,  C07H15/26 ,  C07H3/06 ,  G01N33/5005 ,  G01N33/57469 ,  Y10S435/81

摘要： A more exact, reliable, and simple method for determining the structure of a sugar chain, a kit to be used for this method, and novel oligosaccharides useful for the method as standard sugar chains are provided. The method for determining the structure of an N-acetyllactosamine type of sugar chain is characterized by determining the site of linkage and the mode of linkage of sugar residues at the non-reducing terminal side of a .beta.-N-acetylglucosamine residue linked to an .alpha.-mannose residue in M3 core by means of detecting the presence of the .beta.-N-acetylglucosamine residue after enzymatic or chemical treatment of the sugar chain. The kit for determining the structure of an N-acetyllactosamine type of sugar chain is characterized by containing at least one of the oligosaccharides represented by the chemical formula 1. The oligosaccharide is represented by the chemical formula 4.

摘要翻译： 提供了确定糖链结构的更准确，可靠和简单的方法，用于该方法的试剂盒，以及用作该标准糖链的方法的新型寡糖。 用于确定N-乙酰乳糖胺型糖链结构的方法的特征在于确定与α连接的β-N-乙酰氨基葡萄糖残基的非还原性末端侧的连接位点和连接方式 通过检测糖链的酶或化学处理后β-N-乙酰氨基葡萄糖残基的存在，在M3核心中的 - 甘露糖残基。 用于测定N-乙酰乳糖胺型糖链结构的试剂盒的特征在于含有至少一种由化学式1表示的寡糖。寡糖由化学式4表示。

公开(公告)号：US5089230A

公开(公告)日：1992-02-18

申请号：US491565

申请日：1990-03-09

申请人： Akihiro Kondo ,  Yoshiyuki Kato ,  Ikunoshin Kato ,  Hisao Tsuruta

发明人： Akihiro Kondo ,  Yoshiyuki Kato ,  Ikunoshin Kato ,  Hisao Tsuruta

IPC分类号： B01J19/00 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N35/02 ,  B01J19/0046 ,  B01J2219/0059 ,  G01N2035/00396 ,  G01N2035/00495 ,  G01N2035/00534 ,  Y10T436/11 ,  Y10T436/111666

摘要： A reagent reaction apparatus for automatically performing a reaction by introducing various kinds of reagents to a sample solution. The reagent reaction apparatus includes a number of sample vials within a containing section and a plunger valve with fluid introducing port and a fluid discharge port located on top of the containing section. A mechanism sequentially injects into the sample vial a predetermined amount of reagents into a sample vial containing a measured amount of sample solutions. The sample vial is held in a rotary cone in order to apply centrifugal force. Then, the sample solution and reagents are subjected top a temperature adjusting bath which is preselected for the required reaction temperature. A mechanism transports the final product in the sample vial to a discharge station.

公开(公告)号：US5955324A

公开(公告)日：1999-09-21

申请号：US914155

申请日：1997-08-19

申请人： Jian Qiang Fan ,  Yuan Chuan Lee ,  Kaoru Takegawa ,  Shojiro Iwahara ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Jian Qiang Fan ,  Yuan Chuan Lee ,  Kaoru Takegawa ,  Shojiro Iwahara ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： C12P19/14 ,  C08B37/08 ,  C12P19/26

CPC分类号： C12P19/14

摘要： To provide a process for producing a carbohydrate or a glycoconjugate without forming any hydrolytic product of the remodeled sugar chain.A process for producing a carbohydrate or a glycoconjugate by a remodeling reaction in the presence of a glycosidase which performs the remodeling reaction in an aqueous medium containing a water-soluble ketone and/or dioxane. Examples of the glycosidase include endoglycosidases such as Endo-A. Examples of the ketone include acetone.

摘要翻译： 提供生产碳水化合物或糖缀合物而不形成改性糖链的任何水解产物的方法。 在糖苷酶存在下通过重构反应制备碳水化合物或糖缀合物的方法，所述糖苷酶在含有水溶性酮和/或二恶烷的水性介质中进行重塑反应。 糖苷酶的实例包括内切糖苷酶如Endo-A。 酮的实例包括丙酮。

公开(公告)号：US5472669A

公开(公告)日：1995-12-05

申请号：US19593

申请日：1993-02-19

申请人： Kojiro Miki ,  Takeshi Mori ,  Hiromi Ohkawa ,  Yumi Hosokawa ,  Akihiro Kondo ,  Ikunoshin Kato

发明人： Kojiro Miki ,  Takeshi Mori ,  Hiromi Ohkawa ,  Yumi Hosokawa ,  Akihiro Kondo ,  Ikunoshin Kato

IPC分类号： B67B7/18 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： B67B7/182 ,  G01N35/0099 ,  G01N2035/00495 ,  G01N2035/0405 ,  G01N2035/103 ,  G01N35/109 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Pretreatment apparatus and process for analysis of sugar, the apparatus including a mechanical work hand which moves a vial containing a sample to various stations where reagents are added to the vial and where other pretreatment processes are performed on the sample. The pretreatment apparatus automatically controls the movement of the vial from one station to another and the various processes performed at each station, the processes including removal and storage of the vial's cap, addition of reagents into the vial, centrifugation and heating of the sample, and evaporation of excess reagents.

摘要翻译： 用于分析糖的预处理装置和方法，该装置包括机械手工，其将含有样品的小瓶移动到将试剂加入到小瓶中并在样品上进行其它预处理过程的各个站。 预处理装置自动控制小瓶从一个站到另一个站的移动，以及在每个站处执行的各种过程，包括小瓶盖的移除和储存，向小瓶中加入试剂，离心和加热样品，以及 蒸发过量试剂。