公开(公告)号：US4790820A

公开(公告)日：1988-12-13

申请号：US664802

申请日：1984-10-25

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14 ,  A61M5/00

CPC分类号： A61M5/1407

摘要： A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

摘要翻译： 公开了胃肠外递送系统和制剂室，用于施用有益剂。 胃肠外输送系统包括滴注室和制剂室。 制剂室包括围绕内部空间的壁，并且其具有用于将液体进入制剂室的入口和用于使制剂制剂离开制剂室的出口。 该室容纳用于将有益剂释放到进入室的液体中的药剂递送系统。

公开(公告)号：US4740103A

公开(公告)日：1988-04-26

申请号：US702291

申请日：1985-02-15

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

公开(公告)号：US4728498A

公开(公告)日：1988-03-01

申请号：US438049

申请日：1982-11-01

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A01N25/34 ,  A01N59/00 ,  A61L2/18

CPC分类号： A01N59/00 ,  A01N25/34

摘要： This invention concerns a process for disinfecting an article by placing the article in an aqueous environment comprising a device that dispenses a chlorine donor and a chlorine acceptor that generate a chlorine biocide for disinfecting the article.

摘要翻译： 本发明涉及通过将制品置于包含分配氯供体的装置和产生用于消毒制品的氯生物杀灭剂的氯受体的含水环境中来消毒制品的方法。

公开(公告)号：US4525162A

公开(公告)日：1985-06-25

申请号：US587781

申请日：1984-03-09

申请人： John Urquhart ,  Felix Theeuwes

发明人： John Urquhart ,  Felix Theeuwes

IPC分类号： A61M5/14 ,  A61M5/16

CPC分类号： A61M5/1407

摘要： A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

摘要翻译： 公开了一种用于向接受者施用有益剂的胃肠外递送组。 该组包括（a）医用流体的主要容器; （b）与主容器流体连通的主管; （c）药液的二次容器; （d）与次级容器流体连通的第二管道; （e）与第二管道连接并容纳药剂分配装置或有益药剂的制剂室; 和（f）与主管道和第二管道连通的通用管道，用于将设备传送到接收器。

公开(公告)号：US4511353A

公开(公告)日：1985-04-16

申请号：US310047

申请日：1981-10-09

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

公开(公告)号：US4455145A

公开(公告)日：1984-06-19

申请号：US507330

申请日：1983-06-24

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61K9/00 ,  A61M5/145 ,  B65D83/00 ,  A61M31/00

CPC分类号： B65D83/00 ,  A61K9/0004 ,  A61M2005/14513

摘要： A device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space (2) a piston in the housing separating the space into an agent compartment and a power compartment, or a flexible container in the space, (3) an opening in the housing connecting the agent compartment or the container with the exterior of the housing, and (4) an osmotic device in the power compartment or beneath the container.

摘要翻译： 公开了用于递送有益剂的装置。 该装置包括（1）壳体，其限定内部空间（2）壳体中的活塞，该空间将空间分隔成空间中的空间，动力隔室或柔性容器;（3）壳体中的开口， 代理舱或具有外壳外部的容器，以及（4）动力室或容器下方的渗透装置。

公开(公告)号：US4439183A

公开(公告)日：1984-03-27

申请号：US377831

申请日：1982-05-13

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

摘要翻译： 公开了胃肠外递送系统和制剂室，用于施用有益剂。 胃肠外输送系统包括滴注室和制剂室。 制剂室包括围绕内部空间的壁，并且其具有用于将液体进入制剂室的入口和用于使制剂制剂离开制剂室的出口。 该室容纳用于将有益剂释放到进入室的液体中的药剂递送系统。

公开(公告)号：US4309996A

公开(公告)日：1982-01-12

申请号：US144210

申请日：1980-04-28

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M31/00 ,  A61M7/00

CPC分类号： A61M31/002 ,  A61K9/0004

摘要： A system is disclosed for delivering a beneficial agent at a substantially constant rate over time. The system comprises (1) a wall formed of a microporous polymer, or (2) a wall formed in part of a microporous polymer with the remaining part of the wall formed of a semipermeable polymer. The wall in (1) surrounds a compartment comprising a flexible partition that separates the compartment into a first space containing the beneficial agent and a second space containing a swellable polymer. The wall in (2) surrounds a compartment comprising a flexible partition that separates the compartment into a first space in contact with the microporous wall and containing the beneficial agent, and a second space in contact with the semipermeable polymer containing an osmotically effective solute, or a swellable polymer. In operation, agent is delivered from the system by (a) fluid diffusing through the microporous wall into the second space causing the polymer to swell, or by (b) fluid being imbibed through the semipermeable wall into the second space causing the solute to dissolve and form a solution, or causing the polymer to swell, wherein in (a) or (b), the second space expands against the partition urging it to move into the first space and maintain the agent in a saturated state at the microporous wall, with the agent diffusing from the first space through fluid filled micropaths in the wall from the system at a substantially zero order rate over a prolonged period of time.

摘要翻译： 公开了一种随时间以基本上恒定的速率递送有益试剂的系统。 该系统包括（1）由微孔聚合物形成的壁，或（2）部分由微孔聚合物形成的壁，其余部分壁由半透性聚合物形成。 （1）中的壁围绕包括柔性隔板的隔间，该隔板将隔室分隔成含有有益剂的第一空间和含有可溶胀聚合物的第二空间。 （2）中的壁围绕包括柔性隔板的隔室，该柔性隔板将隔室分隔成与微孔壁接触并包含有益剂的第一空间，以及与含有渗透性有效溶质的半透性聚合物接触的第二空间，或 可溶胀聚合物。 在操作中，通过（a）流体通过微孔壁流体扩散到第二空间中使得聚合物膨胀，或者（b）流体通过半透壁吸入第二空间中，使溶质溶解 并且形成溶液，或使聚合物膨胀，其中在（a）或（b）中，第二空间相对于分隔壁膨胀，促使其移动到第一空间中并将试剂维持在微孔壁处于饱和状态， 其中所述试剂在长时间段内以基本上零级的速率从所述系统从所述第一空间扩散通过所述壁中的流体填充的微通道。

公开(公告)号：US4278087A

公开(公告)日：1981-07-14

申请号：US144211

申请日：1980-04-28

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61K9/00 ,  A61M7/00

CPC分类号： A61K9/0004

摘要： An osmotic device is disclosed for delivering an agent to an environment of use. The device comprises (1) a semipermeable wall, surrounding a compartment with a passageway through the wall for delivering an agent from the compartment, and (2) an osmotic system in the compartment comprising a body formed of a polymer having depots consisting of an agent osmotic solute dispersed in the polymer and surrounded individually by a layer of the polymer. In operation, agent is delivered by the device imbibing fluid from the environment through the semipermeable wall into the compartment, with the system imbiding fluid from the compartment into the depots dissolving the solute and filling the depots with solution, thereby causing the depots to form apertures and release agent, with (a) the system delivering the agent at a controlled rate to the compartment and (b) the device delivering the agent from the compartment at a controlled rate through the passageway to the exterior of the device.

摘要翻译： 公开了用于将试剂递送到使用环境的渗透装置。 该装置包括（1）半透壁，围绕具有通过壁的通道的隔室，用于从隔室输送药剂，和（2）隔室中的渗透系统，包括由聚合物形成的主体，所述聚合物具有由药剂组成的药剂 渗透溶质分散在聚合物中并被聚合物层单独包围。 在操作中，试剂通过装置将来自环境的液体通过半渗透壁输送到隔室中，系统将来自隔室的流体从溶液中溶解并溶解溶质，从而使贮库形成孔 以及（a）系统以受控的速率将该药剂递送到隔室，以及（b）该装置以可控速率通过该通道将该药剂从隔室输送到该装置的外部。

公开(公告)号：US4265874A

公开(公告)日：1981-05-05

申请号：US143644

申请日：1980-04-25

申请人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

发明人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

IPC分类号： B01J4/04 ,  A61K9/00 ,  A61K9/32 ,  A61K9/46 ,  A61J1/00

CPC分类号： A61K9/0004

摘要： A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time. Also, a composition is disclosed comprising the drug and the compound.

摘要翻译： 公开了用于从渗透装置输送基本上不含快速沉淀的药物的方法。 渗透装置包括围绕隔室的半透壁，壳体（1）在中性和酸性条件下表现出有限溶解度的药物; 和（2）能够在酸性存在下在使用环境中放出二氧化碳的化合物。 该方法包括：（a）将流体通过所述壁吸入所述隔室中，所述速率由所述壁的渗透性和穿过所述壁的渗透压梯度确定，（b）在所述室中形成含有药物和化合物的碱性溶液， 溶液通过通道从隔室输送，（c）使化合物与环境中的酸在设备 - 环境界面反应，用于放出二氧化碳，从而（d）在环境中提供泡腾悬浮液，将环境中的药物递送 随着时间的推移，使用环境的细分散形式。 另外，公开了包含药物和化合物的组合物。