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    Methods and compositions for transforming dendritic cells and activating T cells
    91.
    发明授权
    Methods and compositions for transforming dendritic cells and activating T cells 有权
    用于转化树突细胞和激活T细胞的方法和组合物

    公开(公告)号：US06734014B1

    公开(公告)日：2004-05-11

    申请号：US09117764

    申请日：1999-01-07

    申请人： Patrick Hwu ,  Mark Reeves ,  Steven A. Rosenberg

    发明人： Patrick Hwu ,  Mark Reeves ,  Steven A. Rosenberg

    IPC分类号： A61K4800

    CPC分类号： C12N5/0639 ,  A61K2039/5154 ,  A61K2039/5156 ,  C12N2501/22 ,  C12N2501/23

    摘要： Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.

    摘要翻译： 通过转化干细胞并将干细胞分化成树突状细胞制备重组树突状细胞。 所得到的树突状细胞是一种抗原呈递细胞，其激活针对MHC I类抗原靶标的T细胞。 试剂盒，测定法和治疗方法基于重组树突状细胞对T细胞的活化。 癌症，病毒感染和寄生虫感染都由重组树突状细胞或相应的活化T细胞改善。 提供治疗组合物和药物组合物。

    Melanoma antigens and their use in diagnostic and therapeutic methods
    92.
    发明授权
    Melanoma antigens and their use in diagnostic and therapeutic methods 有权
    黑素瘤抗原及其在诊断和治疗方法中的应用

    公开(公告)号：US06270778B1

    公开(公告)日：2001-08-07

    申请号：US09267439

    申请日：1999-03-12

    申请人： Yutaka Kawakami ,  Steven A. Rosenberg

    发明人： Yutaka Kawakami ,  Steven A. Rosenberg

    IPC分类号： A61K3900

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/4748 ,  G01N33/5743

    摘要： The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.

    摘要翻译： 本发明提供编码被称为MART-1的T淋巴细胞识别的黑素瘤抗原的核酸序列。 本发明还涉及使用本发明的核酸序列，蛋白质或抗体诊断，评估或预测患有黑素瘤或转移性黑素瘤的哺乳动物的生物测定。 本发明还提供衍生自MART-1黑素瘤抗原的免疫原性肽和称为gp100的第二黑素瘤抗原。 本发明还提供衍生自MART-1黑素瘤抗原或gp100抗原的免疫原性肽，其已被修饰以增强其免疫原性。 所提供的蛋白质和肽可以作为预防或治疗黑素瘤的免疫原或疫苗。