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公开(公告)号：US20060025372A1
公开(公告)日：2006-02-02
申请号：US11194776
申请日：2005-08-01
申请人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
发明人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US20060019920A1
公开(公告)日：2006-01-26
申请号：US11179128
申请日：2005-07-11
申请人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
CPC分类号： C12N9/1205 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
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93.发明申请Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开固醇调节元件结合蛋白-1表达的反义调制公开(公告)号：US20050215504A1
公开(公告)日：2005-09-29
申请号：US11014360
申请日：2004-12-16
申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。
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94.发明申请Antisense modulation of peroxisome proliferator-activated receptor gamma expression 审中-公开过氧化物酶体增殖物激活受体γ表达的反义调节公开(公告)号：US20050186567A1
公开(公告)日：2005-08-25
申请号：US10181176
申请日：2001-01-11
申请人： Robert McKay , Alexander Borchers , Brenda Baker
发明人： Robert McKay , Alexander Borchers , Brenda Baker
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P3/10 , A61P9/00 , A61P29/00 , A61P35/00 , A61P43/00 , C12N15/113 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Peroxisome proliferator-activated receptor gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Peroxisome proliferator-activated receptor gamma Methods of using these compounds for modulation of Peroxisome proliferator-activated receptor gamma expression and for treatment of diseases associated with expression of Peroxisome proliferator-activated receptor gamma are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节过氧化物酶体增殖物激活受体γ的表达。 组合物包含靶向编码过氧化物酶体增殖物激活受体γ的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节过氧化物酶体增殖物激活受体γ表达和治疗与过氧化物酶体增殖物激活受体表达相关的疾病的方法 提供伽马。
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公开(公告)号：US20050095710A1
公开(公告)日：2005-05-05
申请号：US11008747
申请日：2004-12-09
申请人： Lex Cowsert , Jacqueline Wyatt , Susan Freier , Brett Monia , Madeline Butler , Robert McKay
发明人： Lex Cowsert , Jacqueline Wyatt , Susan Freier , Brett Monia , Madeline Butler , Robert McKay
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/10 , A61P35/00 , C12N15/113 , C07H21/02
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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96.发明申请Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry 审中-公开包括北部和南部构象几何的交替区域的嵌合寡聚化合物公开(公告)号：US20050074801A1
公开(公告)日：2005-04-07
申请号：US10936273
申请日：2004-09-08
申请人： Brett Monia , Madeline Butler , Robert McKay , Brenda Baker
发明人： Brett Monia , Madeline Butler , Robert McKay , Brenda Baker
IPC分类号： C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N2310/32 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2320/51
摘要： The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3′-endo conformational geometry (3′-endo regions) or DNA like having southern or C2′-endo/O4′-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
摘要翻译： 本发明涉及具有多个交替区域的新型嵌合寡聚化合物，所述交替区域具有如具有北或3'-端构象几何（3'-末端区域）的RNA或具有南部或C2'端/ O4'端 构象几何。 本发明的寡聚化合物已显示多个体外和体内测定系统中mRNA水平的降低，并且例如用于调查和治疗目的是有用的。
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公开(公告)号：USD498584S1
公开(公告)日：2004-11-23
申请号：US29195946
申请日：2003-12-18
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公开(公告)号：US06602857B1
公开(公告)日：2003-08-05
申请号：US09629644
申请日：2000-07-31
IPC分类号： A61K3828
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US6030837A
公开(公告)日：2000-02-29
申请号：US366257
申请日：1999-08-03
申请人： Robert McKay , Madeline M. Butler , Lex M. Cowsert
发明人： Robert McKay , Madeline M. Butler , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K9/10 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P3/00 , A61P3/02 , A61P3/10 , A61P43/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12M15/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PEPCK-mitochondrial. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PEPCK-mitochondrial. Methods of using these compounds for modulation of PEPCK-mitochondrial expression and for treatment of diseases associated with expression of PEPCK-mitochondrial are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节PEPCK-线粒体的表达。 组合物包含靶向编码PEPCK-线粒体的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PEPCK-线粒体表达和治疗与PEPCK-线粒体表达相关的疾病的方法。
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