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公开(公告)号：US20060025372A1
公开(公告)日：2006-02-02
申请号：US11194776
申请日：2005-08-01
申请人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
发明人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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3.发明申请Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开固醇调节元件结合蛋白-1表达的反义调制公开(公告)号：US20050215504A1
公开(公告)日：2005-09-29
申请号：US11014360
申请日：2004-12-16
申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。
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公开(公告)号：US20060160758A1
公开(公告)日：2006-07-20
申请号：US11039632
申请日：2005-01-20
申请人： C. Bennett , Susan Freier , Brenda Baker , Brett Monia , Nicholas Dean , Hong Zhang , Susan Murray , Lex Cowsert , Madeline Butler , Robert McKay , Donna Ward , William Gaarde , Ian Popoff , Jacqueline Wyatt , Andrew Watt
发明人： C. Bennett , Susan Freier , Brenda Baker , Brett Monia , Nicholas Dean , Hong Zhang , Susan Murray , Lex Cowsert , Madeline Butler , Robert McKay , Donna Ward , William Gaarde , Ian Popoff , Jacqueline Wyatt , Andrew Watt
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.
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公开(公告)号：US20050095710A1
公开(公告)日：2005-05-05
申请号：US11008747
申请日：2004-12-09
申请人： Lex Cowsert , Jacqueline Wyatt , Susan Freier , Brett Monia , Madeline Butler , Robert McKay
发明人： Lex Cowsert , Jacqueline Wyatt , Susan Freier , Brett Monia , Madeline Butler , Robert McKay
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/10 , A61P35/00 , C12N15/113 , C07H21/02
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US20060019920A1
公开(公告)日：2006-01-26
申请号：US11179128
申请日：2005-07-11
申请人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
CPC分类号： C12N9/1205 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
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公开(公告)号：US20070066557A1
公开(公告)日：2007-03-22
申请号：US11524507
申请日：2006-09-19
申请人： Brett Monia , Robert McKay , Susan Freier , Sanjay Bhanot , Lynnetta Watts
发明人： Brett Monia , Robert McKay , Susan Freier , Sanjay Bhanot , Lynnetta Watts
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for treatment of diseases are provided.
摘要翻译： 提供化合物，组合物和方法用于调节糖皮质激素受体的表达。 组合物包含靶向编码糖皮质激素受体的核酸的反义化合物，特别是具有特定体内特性的反义寡核苷酸。 提供了使用这些化合物调节糖皮质激素受体表达和治疗疾病的方法。
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公开(公告)号：US20070238687A1
公开(公告)日：2007-10-11
申请号：US11697262
申请日：2007-04-05
申请人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
发明人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
IPC分类号： A61K31/711 , A61K31/7105 , A61K31/7125 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
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公开(公告)号：US20070238689A1
公开(公告)日：2007-10-11
申请号：US11697273
申请日：2007-04-05
申请人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
发明人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
IPC分类号： A61K31/711 , A61K31/7105 , A61K31/7125 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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公开(公告)号：US20070238688A1
公开(公告)日：2007-10-11
申请号：US11697270
申请日：2007-04-05
申请人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
发明人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
IPC分类号： A61K31/711 , A61K31/7105 , A61K31/7125 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
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