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116 条记录 (耗时 0.067 秒)

    Method for screening of potential anti-epileptic drugs using a Drosophila melanogaster model
    93.
    发明授权
    Method for screening of potential anti-epileptic drugs using a Drosophila melanogaster model 失效
    使用黑腹果蝇模型筛选潜在的抗癫痫药物的方法

    公开(公告)号：US06291739B1

    公开(公告)日：2001-09-18

    申请号：US09535517

    申请日：2000-03-24

    申请人： Abhay Sharma ,  Sushil Kumar

    发明人： Abhay Sharma ,  Sushil Kumar

    IPC分类号： G01N3300

    CPC分类号： A01K67/033

    摘要： The invention relates to a method for screening anti-epileptic drugs using fruit fly Drosophila melanogaster by generating single and double mutant lines of K+ channel genes in Drosophila melanogaster, culturing mutant lines on Drosophila medium under standard conditions, identifying the mutants, separating male flies under ether anesthesia, supplying the mutant males with medium containing each of the four antiepileptic drugs, phenobarbital, phenytoin, carbaamazepine and valproate, separately, administering ether anesthesia to the drug treated flies and examining their leg shaking intensity under stereomicroscope, observing the antiepileptic effect in the drug treated males wherein a reduced intensity of leg shaking, compared to leg shaking in normally fed etherized males, is indicative of antiepileptic activity in the drug.

    摘要翻译： 本发明涉及一种通过在果蝇中产生K +通道基因的单突变和双重突变体系，在果蝇培养基上培养突变体系，鉴定突变体，分离雄性苍蝇的本发明涉及使用果蝇黑腹果蝇筛选抗癫痫药物的方法 乙醚麻醉，分别向四种抗癫痫药物，苯巴比妥，苯妥英，卡马西平和丙戊酸各自的培养基中供应突变体雄性，对药物处理的苍蝇进行乙醚麻醉，并在立体显微镜下观察其腿部振动强度，观察其抗癫痫作用 药物治疗的男性，其中与正常喂养的被熟化的雄性的腿部颤动相比，腿部抖动的强度降低，表明药物中的抗癫痫活性。

    Process for the production of 4-aryl-2 butanols from Taxus wallichiana
    95.
    发明授权
    Process for the production of 4-aryl-2 butanols from Taxus wallichiana 有权
    从Taxus wallichiana生产4-芳基-2丁醇的方法

    公开(公告)号：US06184367B2

    公开(公告)日：2001-02-06

    申请号：US09358113

    申请日：1999-07-21

    申请人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar

    发明人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar

    IPC分类号： C07C3982

    CPC分类号： C07H15/18 ,  C07C37/004 ,  C07H1/08 ,  C07C39/11

    摘要： The present invention provides a process for the production of two molecules of 4-aryl-2 butanols having the general formula 1 given below: Wherein R═H or glucose from the leaves of Taxus wallichiana, which comprises: (a) defatting air dried, pulverized leaves with aliphatic hydrocarbon solvents, (b) extracting the defatted leaves with chlorinated solvents and polar solvent successively at room temperature, (b) concentrating the chlorinated solvent soluble faction to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvents, (d) acidifying the alkali layer with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate phase to give compound of formula 1 where R═H, (e) concentrating the polar solvent fraction from step (b) to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvent, and (f) acidifying the alkali phase with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate to give compound of formula 1 where R=glucose.

    摘要翻译： 本发明提供了一种生产具有下列通式1的两分子的4-芳基-2丁醇的方法：其中R = H或来自红豆杉叶的葡萄糖，其包括：（a）将空气干燥脱脂， 用脂肪族烃溶剂粉碎叶片，（b）在室温下连续用氯化溶剂和极性溶剂萃取脱脂叶，（b）将氯化溶剂可溶部分浓缩至残留物，用碱水溶液处理残留物，用氯化物萃取 溶剂，（d）用无机酸酸化碱层并用乙酸乙酯萃取并浓缩乙酸乙酯相，得到其中R = H的式1化合物，（e）将步骤（b）的极性溶剂级分浓缩至残余物 并用碱水溶液处理残留物，用氯化溶剂萃取，（f）用无机酸酸化碱相，用乙酸乙酯萃取 并浓缩乙酸乙酯，得到其中R =葡萄糖的式1化合物。

    Tissue culture process for producing a large number of viable mint plants in vitro from internodal segments
    97.
    发明授权
    Tissue culture process for producing a large number of viable mint plants in vitro from internodal segments 失效
    组织培养方法，用于在体外从节间段产生大量可行的薄荷植物

    公开(公告)号：US5898001A

    公开(公告)日：1999-04-27

    申请号：US792545

    申请日：1997-01-31

    申请人： Sushil Kumar ,  Shiv Kumar Gupta ,  Savithri Bhat ,  Rakesh Tuli

    发明人： Sushil Kumar ,  Shiv Kumar Gupta ,  Savithri Bhat ,  Rakesh Tuli

    IPC分类号： A01H4/00 ,  C12N5/04 ,  C12N5/00

    CPC分类号： A01H4/008

    摘要： The present invention relates to a tissue culture process for producing a large number of viable mint plants in vitro. The process of the present invention employs specified pieces of an internodal segment of the stem of the mint plant as the starting material and identifies medium and culture conditions for producing a large number of plants. Such plants can be used for micropropagation, selection of mutants, production of plants with altered levels of endogenous secondary metabolites and for genetic engineering.

    摘要翻译： 本发明涉及用于在体外生产大量活的薄荷植物的组织培养方法。 本发明的方法使用薄荷植物的茎的节间段的指定片段作为起始材料，并且识别用于生产大量植物的培养条件。 这样的植物可以用于微繁殖，突变体的选择，产生具有改变的内源性次级代谢物水平的植物和遗传工程。

    Sequential state elements radiation hardened by design
    98.
    发明授权
    Sequential state elements radiation hardened by design 有权
    通过设计辐射硬化的顺序状态元件

    公开(公告)号：US09054688B2

    公开(公告)日：2015-06-09

    申请号：US14031585

    申请日：2013-09-19

    申请人： Lawrence T. Clark ,  Sandeep Shambhulingaiah ,  Sushil Kumar ,  Chandarasekaran Ramamurthy

    发明人： Lawrence T. Clark ,  Sandeep Shambhulingaiah ,  Sushil Kumar ,  Chandarasekaran Ramamurthy

    IPC分类号： H03K3/289 ,  H03K3/356 ,  G06F17/50 ,  H03K3/037 ,  H03K3/3562

    CPC分类号： H03K3/356086 ,  G06F17/5072 ,  G06F2217/70 ,  H03K3/0375 ,  H03K3/35606 ,  H03K3/35625

    摘要： This disclosure relates generally to sequential state elements (SSEs). More specifically, embodiments of flip-flops are disclosed, along with computerized methods and systems of designing the same. In one embodiment, the flip-flop includes a substrate and subcircuits that are formed on the substrate. The subcircuits provide subfunctions, wherein each of the subcircuits provides at least one of the subfunctions. More specifically, the subfunctions are provided in a sequential logical order by the subcircuits so that the flip-flop provides a flip-flop function. However, the subcircuits are interleaved out of the sequential logical order with respect to a corresponding subfunction provided by each of the subcircuits along a vector defined by the substrate. In this manner, interleaving the subcircuits along the vector of the substrate can provide separation between charge collection nodes without requiring increases in size. Thus, the flip-flop can be more compact and less expensive to manufacture.

    摘要翻译： 本公开一般涉及顺序状态元素（SSEs）。 更具体地，公开了触发器的实施例，以及计算机化的方法和设计它们的系统。 在一个实施例中，触发器包括形成在衬底上的衬底和子电路。 子电路提供子功能，其中每个子电路提供至少一个子功能。 更具体地，通过子电路以顺序逻辑顺序提供子功能，使得触发器提供触发器功能。 然而，子电路相对于由基板限定的矢量由每个子电路提供的相应的子功能从顺序逻辑顺序交错。 以这种方式，沿着衬底的矢量交叉子电路可以提供电荷收集节点之间的间隔，而不需要增加尺寸。 因此，触发器可以更紧凑并且制造成本更低。

    Pre-fetching content items based on social distance
    99.
    发明授权
    Pre-fetching content items based on social distance 有权
    根据社交距离预取内容

    公开(公告)号：US08539161B2

    公开(公告)日：2013-09-17

    申请号：US12577464

    申请日：2009-10-12

    申请人： Bo Lu ,  Raghavendra Malpani ,  Joseph A. Porkka ,  Bartosz Henryk Paliswiat ,  Christian Bøgh Jensen ,  Sushil Kumar

    发明人： Bo Lu ,  Raghavendra Malpani ,  Joseph A. Porkka ,  Bartosz Henryk Paliswiat ,  Christian Bøgh Jensen ,  Sushil Kumar

    IPC分类号： G06F12/00 ,  G06F13/00 ,  G06F13/28 ,  G06F15/16 ,  G06Q99/00

    CPC分类号： G06F17/30867 ,  G06F17/30902

    摘要： Retrieving content items based on a social distance between a user and content providers. The social distance is determined based on, for example, user interaction with the content providers. The content providers are ranked, for the user, based on the determined social distance. Prior to a request from the user, the content items are pre-fetched based on the ranked content providers and constraints such as storage space, bandwidth, and battery power level of a computing device of the user. In some embodiments, additional content items are retrieved, or retrieved content items are deleted, as a variable-size cache on the computing device fills or changes size.

    摘要翻译： 基于用户和内容提供商之间的社交距离检索内容项。 基于例如用户与内容提供商的交互来确定社交距离。 内容提供商根据确定的社交距离对用户进行排名。 在来自用户的请求之前，基于排名内容提供商和诸如用户的计算设备的存储空间，带宽和电池功率级别的约束来预取内容项。 在一些实施例中，随着计算设备上的可变大小的高速缓存填充或改变大小，检索附加内容项目或检索到的内容项目。

    Mixer with local oscillator feed-forward and method of mixing signals with local oscillator feed-forward
    100.
    发明授权
    Mixer with local oscillator feed-forward and method of mixing signals with local oscillator feed-forward 有权
    具有本地振荡器前馈的混频器和与本地振荡器前馈混合信号的方法

    公开(公告)号：US08131248B2

    公开(公告)日：2012-03-06

    申请号：US12244091

    申请日：2008-10-02

    申请人： Sushil Kumar

    发明人： Sushil Kumar

    IPC分类号： H04B1/26

    CPC分类号： H03D7/165

    摘要： A feed-forward device is provided for a mixer including a diplexer having a radio frequency port, an intermediate frequency port, and a common port; and a mixing circuit receiving an in-phase local oscillator signal and an out-of-phase local oscillator signal and having an output coupled to the common port of the diplexer. The feed-forward device includes: a first signal sampler having an input adapted to sample the in-phase local oscillator signal and to output a sampled in-phase local oscillator signal; a second signal sampler having an input adapted to sample the out-of-phase local oscillator signal and to output a sampled out-of-phase local oscillator signal; and an arrangement for coupling the sampled in-phase local oscillator signal and the sampled out-of-phase local oscillator signal to the common port of the diplexer.

    摘要翻译： 提供一种用于包括具有射频端口，中频端口和公共端口的双工器的混频器的前馈装置; 以及混合电路，其接收同相本地振荡器信号和异相本地振荡器信号，并具有耦合到双工器的公共端口的输出。 前馈装置包括：第一信号采样器，其具有适于对同相本地振荡器信号进行采样并输出采样的同相本地振荡器信号的输入; 第二信号采样器，其具有适于对异相本地振荡器信号进行采样并输出采样的异相本地振荡器信号的输入; 以及用于将采样的同相本机振荡器信号和采样的异相本地振荡器信号耦合到双工器的公共端口的装置。