Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
    92.
    发明申请
    Kallikrein inhibitors and anti-thrombolytic agents and uses thereof 有权
    激肽释放酶抑制剂和抗溶栓剂及其用途

    公开(公告)号:US20090264350A1

    公开(公告)日:2009-10-22

    申请号:US11804388

    申请日:2007-05-18

    CPC classification number: A61K38/55 A61K31/195 A61K38/57 A61K45/06 A61K2300/00

    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

    Abstract translation: 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂(例如抗纤维蛋白溶解剂)的方法,试剂盒和组合物,用于预防或减少失血和/或缺血,例如与围手术期失血相关的缺血 脑缺血,全身炎症反应发作和/或再灌注损伤,例如与脑缺血或局灶性脑缺血相关的再灌注损伤,例如在经历侵入性外科手术的患者中,特别是需要体外循环的手术。

    Kallikrein Inhibitors and Anti-thrombolytic Agents and Uses Thereof
    93.
    发明申请
    Kallikrein Inhibitors and Anti-thrombolytic Agents and Uses Thereof 审中-公开
    激肽释放酶抑制剂和抗溶栓剂及其用途

    公开(公告)号:US20090247453A1

    公开(公告)日:2009-10-01

    申请号:US11931941

    申请日:2007-10-31

    CPC classification number: A61K38/55 A61K31/195 A61K38/57 A61K45/06 A61K2300/00

    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

    Abstract translation: 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂(例如抗纤维蛋白溶解剂)的方法,试剂盒和组合物,用于预防或减少失血和/或缺血,例如与围手术期失血相关的缺血 脑缺血,全身炎症反应发作和/或再灌注损伤,例如与脑缺血或局灶性脑缺血相关的再灌注损伤,例如在经历侵入性外科手术的患者中,特别是需要体外循环的手术。

    Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof
    95.
    发明申请
    Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof 审中-公开
    激肽释放酶抑制剂和抗血栓溶解剂及其用途

    公开(公告)号:US20090227495A1

    公开(公告)日:2009-09-10

    申请号:US11931810

    申请日:2007-10-31

    CPC classification number: A61K38/55 A61K31/195 A61K38/57 A61K45/06 A61K2300/00

    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

    Abstract translation: 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂(例如抗纤维蛋白溶解剂)的方法,试剂盒和组合物,用于预防或减少失血和/或缺血,例如与围手术期失血相关的缺血 脑缺血,全身炎症反应发作和/或再灌注损伤,例如与脑缺血或局灶性脑缺血相关的再灌注损伤,例如在经历侵入性外科手术的患者中,特别是需要体外循环的手术。

    Air-gap-insulated exhaust manifold
    96.
    发明授权
    Air-gap-insulated exhaust manifold 有权
    气隙绝缘排气歧管

    公开(公告)号:US07434390B2

    公开(公告)日:2008-10-14

    申请号:US11116027

    申请日:2005-04-27

    CPC classification number: F01N13/102 F01N2470/24

    Abstract: The present invention relates to an air-gap-insulated exhaust manifold (1) of an internal combustion engine, in particular in a motor vehicle, having a collecting line (2) that extends in a longitudinal direction (3), an outlet opening (4) oriented in the longitudinal direction (3), multiple inlet openings (5) oriented across the longitudinal direction (3) and a flange (6) that extends in the longitudinal direction (3) and includes the inlet openings (5), wherein an inside pipe (11) is situated in an outside pipe (10), forming an air-gap insulation, and whereby a gas-carrying outside pipe section (13) is provided in the area of at least one of the inlet openings (5) and leads from the respective inlet opening (5) to an assigned inside pipe inlet (14) which is at a distance from the flange (6). The inside pipe (11) is attached to the outside pipe (10) only in an attachment area (15).

    Abstract translation: 本发明涉及一种内燃机,特别是机动车辆的气隙绝缘排气歧管(1),具有沿纵向方向(3)延伸的收集线(2),出口开口 (3)上定向的多个入口开口(5)和沿纵向方向(3)延伸并包括入口开口(5)的凸缘(6),其中, 内管(11)位于外管(10)中,形成气隙绝缘体,并且在至少一个入口(5)的区域中设置气体输送外管部(13) )并且从相应的入口(5)引导到与凸缘(6)相距一定距离的分配的内部管入口(14)。 内部管道(11)仅在附接区域(15)附接到外部管道(10)。

    Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof
    97.
    发明申请
    Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof 审中-公开
    激肽释放酶抑制剂和抗血栓溶解剂及其用途

    公开(公告)号:US20080221031A1

    公开(公告)日:2008-09-11

    申请号:US11932098

    申请日:2007-10-31

    CPC classification number: A61K38/55 A61K31/195 A61K38/57 A61K45/06 A61K2300/00

    Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.

    Abstract translation: 描述了包括非天然存在的激肽释放酶抑制剂和抗血栓溶解剂(例如抗纤维蛋白溶解剂)的方法,试剂盒和组合物,用于预防或减少失血和/或缺血,例如与围手术期失血相关的缺血 脑缺血,全身炎症反应发作和/或再灌注损伤,例如与脑缺血或局灶性脑缺血相关的再灌注损伤,例如在经历侵入性外科手术的患者中,特别是需要体外循环的手术。

    Method for the production of a hole and device
    98.
    发明申请
    Method for the production of a hole and device 有权
    生产孔和装置的方法

    公开(公告)号:US20070119832A1

    公开(公告)日:2007-05-31

    申请号:US10574724

    申请日:2004-09-02

    Abstract: Previous methods for the production of a hole in a component are very time-consuming and expensive, as special lasers having ultra short laser pulse lengths are used. The inventive method varies laser pulse lengths and ultra short laser pulse lengths are used exclusively in the region which is to be removed, wherein it is possible to have a noticeable influence on through flow and/or out-flow behavior. This, for example, the inner surface of a diffuser of a hole, which can be produced in a precise manner using ultra short laser pulse lengths.

    Abstract translation: 由于使用具有超短激光脉冲长度的特殊激光器,因此在组件中产生孔的先前方法非常耗时且昂贵。 本发明的方法改变激光脉冲长度,并且超短激光脉冲长度仅用于要去除的区域中,其中可能对通过流动和/或流出行为具有明显的影响。 例如,可以使用超短激光脉冲长度精确地制造孔的扩散器的内表面。

    Pneumatic biasing of a linear actuator and implementations thereof
    99.
    发明申请
    Pneumatic biasing of a linear actuator and implementations thereof 有权
    线性致动器的气动偏压及其实施方案

    公开(公告)号:US20070068399A1

    公开(公告)日:2007-03-29

    申请号:US11526362

    申请日:2006-09-25

    CPC classification number: B30B1/38 B30B1/18 Y10T74/1868

    Abstract: An improved method and apparatus are provided for constructing and operating a linear actuator, and equipment incorporating a linear actuator, by operatively connecting a pressure biasing pneumatic arrangement between the driving member and the driven member of a mechanical linear actuator for applying a unidirectional biasing force between the driving and driven members, along an axis of motion, regardless of the location or movement of the driving and driven elements with respect to one another along the axis of motion. The pneumatic biasing arrangement is also configured, connected and operated to reduce the force which must be exerted by the driving and driven members in extending and retracting the linear actuator. The pneumatic biasing arrangement may further be configured for preferentially aiding extension or retraction of the actuator.

    Abstract translation: 提供了一种改进的方法和装置,用于构造和操作线性致动器,以及包括线性致动器的设备,通过在机械线性致动器的驱动构件和从动构件之间可操作地连接压力偏压气动装置,以在机械线性致动器之间施加单向偏置力 驱动和被驱动构件沿着运动轴线,而不管驱动元件和被驱动元件相对于运动轴线相对于彼此的位置或运动如何。 气动偏压装置还被构造,连接和操作以减小驱动和被驱动构件在伸直和缩回线性致动器时必须施加的力。 气动偏压装置还可以被配置为优先地辅助致动器的伸展或缩回。

    Casting mold
    100.
    发明申请
    Casting mold 失效
    铸造模具

    公开(公告)号:US20060032604A1

    公开(公告)日:2006-02-16

    申请号:US10977736

    申请日:2004-10-28

    CPC classification number: B22C9/24 B22C9/00 B22C9/04 B22C9/10

    Abstract: According to the prior art, through-holes in components are often introduced after the production (casting) of the component. This entails additional outlay in terms of time and equipment. The time required can be considerably shortened if a casting mold is designed in such a way that the through-hole is at least in part formed by corresponding projections being formed on the inner wall and/or the outer wall of the casting mold.

    Abstract translation: 根据现有技术,在部件的生产(铸造)之后经常引入部件中的通孔。 这需要在时间和设备方面的额外费用。 如果铸模被设计成使得通孔至少部分地由形成在铸模的内壁和/或外壁上的相应突起形成的方式来缩短所需的时间。

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